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Cited by 119Viral Infections and Immunology ResearchEvolution and Genetic DynamicsVirology and Viral Diseases

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Molecular Evolution of a Type 1 Wild-Vaccine Poliovirus Recombinant during Widespread Circulation in China

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Liu, Hong-Mei, Zheng, Du-Ping, Zhang, Li-Bi, Oberste, M. Steven, Pallansch, Mark A., Kew, Olen M.·2000·Journal of Virology
DOI 10.1128/jvi.74.23.11153-11161.2000PMC PMC113202
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Abstract

Type 1 wild-vaccine recombinant polioviruses were isolated from poliomyelitis patients in China from 1991 to 1993. We compared the sequences of 34 recombinant isolates over the 1,353-nucleotide (nt) genomic interval (nt 2480 to 3832) encoding the major capsid protein, VP1, and the protease, 2A. All recombinants had a 367-nt block of sequence (nt 3271 to 3637) derived from the Sabin 1 oral poliovirus vaccine strain spanning the 3′-terminal sequences of VP1 (115 nt) and the 5′ half of 2A (252 nt). The remaining VP1 sequences were closely (up to 99.5%) related to those of a major genotype of wild type 1 poliovirus endemic to China up to 1994. In contrast, the non-vaccine-derived sequences at the 3′ half of 2A were more distantly related (<90% nucleotide sequence match) to those of other contemporary wild polioviruses from China. The vaccine-derived sequences of the earliest (April 1991) isolates completely matched those of Sabin 1. Later isolates diverged from the early isolates primarily by accumulation of synonymous base substitutions (at a rate of ∼3.7 × 10 −2 substitutions per synonymous site per year) over the entire VP1-2A interval. Distinct evolutionary lineages were found in different Chinese provinces. From the combined epidemiologic and evolutionary analyses, we propose that the recombinant virus arose during mixed infection of a single individual in northern China in early 1991 and that its progeny spread by multiple independent chains of transmission into some of the most populous areas of China within a year of the initiating infection.

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Crossref · 10.1128/jvi.74.23.11153-11161.2000

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Research works printed but not linked: 1

  1. Zheng D.-P. Zhang L.-B. Hou X.-H. Zhu H. Otten M. Kilpatrick D. R. Pallansch M. A. Kew O. M. Molecular epidemiology of poliovirus in China in the epidemic period of 1989–1994.Chin. J. Virol. 12 1995 289 298

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Metadata

Authors
Liu, H.-M., Zheng, D.-P., Zhang, L.-B., Oberste, M. S., Pallansch, M. A., & Kew, O. M.
Affiliations
  • <!--label omitted: 1-->Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333,1 and
  • Centers for Disease Control and Prevention (US)
  • <!--label omitted: 3-->National Poliovirus Reference Center, Institute of Virology, Chinese Academy of Preventive Medicine, Beijing 100052,3 People's Republic of China
ORCID
Venue
Journal of Virology
Publisher
American Society for Microbiology
Published
2000-12
Volume
74
Issue
23
Pages
11153-11161
ISSN
  • 0022-538X (ISSN-L)
  • 1098-5514
DOI
10.1128/jvi.74.23.11153-11161.2000
PMC
PMC113202
OpenAlex
W1993390912
Cited by
119
References
47
Citations by year
2026: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 7
FWCI
5.18
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Journal of Virology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Centers for Disease Control and Prevention
Topics
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords
poliovirus type 1, molecular evolution, VP1, 2A protease, synonymous substitutions, co-infection, poliomyelitis, China
MeSH terms
Base Sequence, Capsid, Cysteine Endopeptidases, Biological Evolution, Molecular Sequence Data, Recombination, Genetic, Viral Proteins, Poliovirus, Capsid Proteins

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