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Cited by 88Viral Infections and Immunology ResearchVirology and Viral DiseasesEvolution and Genetic Dynamics

Serial Recombination during Circulation of Type 1 Wild-Vaccine Recombinant Polioviruses in China

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Liu, Hong-Mei, Zheng, Du-Ping, Zhang, Li-Bi, Oberste, M. Steven, Kew, Olen M., Pallansch, Mark A.·2003·Journal of Virology
DOI 10.1128/jvi.77.20.10994-11005.2003PMC PMC225006
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Abstract

Type 1 wild-vaccine recombinant polioviruses sharing a 367-nucleotide (nt) block of Sabin 1-derived sequence spanning the VP1 and 2A genes circulated widely in China from 1991 to 1993. We surveyed the sequence relationships among 34 wild-vaccine recombinants by comparing six genomic intervals: the conserved 5′-untranslated region (5′-UTR) (nt 186 to 639), the hypervariable portion of the 5′-UTR (nt 640 to 742), the VP4 and partial VP2 genes (nt 743 to 1176), the VP1 gene (nt 2480 to 3385), the 2A gene (nt 3386 to 3832), and the partial 3D gene (nt 6011 to 6544). The 5′-UTR, capsid (VP4-VP2 and VP1), and 2A sequence intervals had similar phylogenies. By contrast, the partial 3D sequences could be distributed into five divergent genetic classes. Most (25 of 34) of the wild-vaccine recombinant isolates showed no evidence of additional recombination beyond the initial wild-Sabin recombination event. Eight isolates from 1992 to 1993, however, appear to be derived from three independent additional recombination events, and one 1993 isolate was derived from two consecutive events. Complete genomic sequences of a representative isolate for each 3D sequence class demonstrated that these exchanges had occurred in the 2B, 2C, and 3D genes. The 3D gene sequences were not closely related to those of the Sabin strains or 53 diverse contemporary wild poliovirus isolates from China, but all were related to the 3D genes of species C enteroviruses. The appearance within approximately 2.5 years of five recombinant classes derived from a single ancestral infection illustrates the rapid emergence of new recombinants among circulating wild polioviruses.

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  • The rapid evolution of polioviruses during natural replication permits the patterns of poliovirus transmission to be followed with unparalleled precision.

    “The rapid evolution of polioviruses during natural replication permits the patterns of poliovirus transmission to be followed with unparalleled precision (108, 179).”

    From VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION (2005) · cites this paper as [108]

  • They also appear to be largely independent of immune selection, as evolution rates are similar during prolonged replication in immunodeficient patients and during widespread circulation.

    “They also appear to be largely independent of immune selection, as evolution rates are similar during prolonged replication in immunodeficient patients (10, 88, 117, 223) and during widespread circulation (60, 84, 85, 108).”

    From VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION (2005) · cites this paper as [108]

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  1. [16]Kew, O. M., and B. K. Nottay. 1984. Evolution of the oral polio vaccine strains in humans occurs by both mutation and intramolecular recombination, p. 357-362. In R. Lerner and R. Chanock (ed.), Modern approaches to vaccines. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.

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Authors
Liu, H.-M., Zheng, D.-P., Zhang, L.-B., Oberste, M. S., Kew, O. M., & Pallansch, M. A.
Affiliations
  • Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333
  • Centers for Disease Control and Prevention (US)
  • National Poliovirus Reference Center, Chinese Center for Disease Control and Prevention, Beijing 100052, People's Republic of China
ORCID
Venue
Journal of Virology
Publisher
American Society for Microbiology
Published
2003-10-15
Volume
77
Issue
20
Pages
10994-11005
ISSN
  • 0022-538X (ISSN-L)
  • 1098-5514
DOI
10.1128/jvi.77.20.10994-11005.2003
PMC
PMC225006
OpenAlex
W2107363398
Cited by
88
References
47
Citations by year
2023: 4 · 2022: 1 · 2021: 1 · 2020: 2 · 2018: 1 · 2017: 1 · 2016: 5 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 6
FWCI
5.95
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Journal of Virology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Centers for Disease Control and Prevention
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords
poliovirus type 1, 3D gene, 5' untranslated region, VP1 gene, phylogenetic analysis, poliovirus evolution, China
MeSH terms
Base Sequence, Capsid, China, Molecular Sequence Data, Phylogeny, Poliovirus Vaccine, Oral, Recombination, Genetic, Genome, Viral, Poliovirus

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