The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Relative Sensitivity of Hepatitis B Virus and Other Hepatotropic Viruses to the Antiviral Effects of Cytokines
Open accessAbstract
We have previously shown that hepatitis B virus (HBV) replication is inhibited noncytopathically in the livers of transgenic mice following injection of HBV-specific cytotoxic T lymphocytes (CTLs) or infection with unrelated hepatotropic viruses, including lymphocytic choriomeningitis virus (LCMV) and adenovirus. These effects are mediated by gamma interferon (IFNγ), tumor necrosis factor alpha (TNFα), and IFNα/β. In the present study, we crossed HBV transgenic mice with mice genetically deficient for IFNγ (IFNγKO), the TNFα receptor (TNFαRKO), or the IFNα/β receptor (IFNα/βRKO) in order to determine the relative contribution of each cytokine to the antiviral effects observed in each of these systems. Interestingly, we showed that HBV replicates in unmanipulated IFNγKO and IFNα/βRKO mice at levels higher than those observed in control mice, implying that baseline levels of these cytokines control HBV replication in the absence of inflammation. We also showed that IFNγ mediates most of the antiviral effect of the CTLs while IFNα/β is primarily responsible for the early inhibitory effect of LCMV and adenovirus on HBV replication. In addition, we showed that the hepatic induction of IFNα/β observed after injection of poly(I · C) is sufficient to inhibit HBV replication and that a similar antiviral effect is achieved by systemic administration of very high doses of IFNα. We also compared the relative sensitivity of LCMV and adenovirus to control by IFNγ, TNFα, or IFNα/β in these animals. Importantly, IFNα/βRKO mice, and to a lesser extent IFNγKO mice, showed higher hepatic levels of LCMV RNA and adenovirus DNA and RNA than control mice, underscoring the importance of both interferons in controlling these other viral infections as well.
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Cites
Functional Role of Type I and Type II Interferons in Antiviral Defense
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Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes
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Hepatitis B Virus Immunopathogenesis
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Self-citationViral Clearance Without Destruction of Infected Cells During Acute HBV Infection
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Self-citationIdentity of tumour necrosis factor and the macrophage-secreted factor cachectin
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Intracellular Inactivation of the Hepatitis B Virus by Cytotoxic T Lymphocytes
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Self-citationHigh-level hepatitis B virus replication in transgenic mice
Guidotti, L. G., Matzke, B., Schaller, H., & Chisari, F. V. (1995) · Journal of Virology · doi:10.1128/jvi.69.10.6158-6169.1995 · Cited by 642
Self-citationYang, Y., Ertl, H. C. J., & Wilson, J. M. (1994) · Immunity · doi:10.1016/1074-7613(94)90074-4 · Cited by 611
Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis.
Ando, K., Moriyama, T., Guidotti, L. G., Wirth, S., Schreiber, R. D., Schlicht, H. J., Huang, S. N., & Chisari, F. V. (1993) · The Journal of experimental medicine · doi:10.1084/jem.178.5.1541 · Cited by 449
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Cited by
Immunobiology and pathogenesis of hepatitis B virus infection
Iannacone, M., & Guidotti, L. G. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-021-00549-4 · Cited by 520
Self-citationHepatocyte Death: A Clear and Present Danger
Malhi, H., Guicciardi, M. E., & Gores, G. J. (2010) · Physiological Reviews · doi:10.1152/physrev.00061.2009 · Cited by 477
Pathogenesis of hepatitis B virus infection
Chisari, F. V., Isogawa, M., & Wieland., S. F. (2010) · Pathologie Biologie · doi:10.1016/j.patbio.2009.11.001 · Cited by 414
Self-citationKakimi, K., Lane, T. E., Wieland, S., Asensio, V. C., Campbell, I. L., Chisari, F. V., & Guidotti, L. G. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.12.1755 · Cited by 234
Self-citationOscillating CD8+ T Cell Effector Functions after Antigen Recognition in the Liver
Isogawa, M., Furuichi, Y., & Chisari, F. V. (2005) · Immunity · doi:10.1016/j.immuni.2005.05.005 · Cited by 186
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Metadata
- Authors
- McClary, H., Koch, R., Chisari, F. V., & Guidotti, L. G.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2000-03
- Volume
- 74
- Issue
- 5
- Pages
- 2255-2264
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2038992316
- Cited by
- 255
- References
- 20
- FWCI
- 11.33
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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