The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Complementary Strand of the Human T-Cell Leukemia Virus Type 1 RNA Genome Encodes a bZIP Transcription Factor That Down-Regulates Viral Transcription
Open accessAbstract
The RNA genome of the human T-cell leukemia virus type 1 (HTLV-1) codes for proteins involved in infectivity, replication, and transformation. We report in this study the characterization of a novel viral protein encoded by the complementary strand of the HTLV-1 RNA genome. This protein, designated HBZ (for HTLV-1 bZIP factor), contains a N-terminal transcriptional activation domain and a leucine zipper motif in its C terminus. We show here that HBZ is able to interact with the bZIP transcription factor CREB-2 (also called ATF-4), known to activate the HTLV-1 transcription by recruiting the viral trans -activator Tax on the Tax-responsive elements (TxREs). However, we demonstrate that the HBZ/CREB-2 heterodimers are no more able to bind to the TxRE and cyclic AMP response element sites. Taking these findings together, the functional inactivation of CREB-2 by HBZ is suggested to contribute to regulation of the HTLV-1 transcription. Moreover, the characterization of a minus-strand gene protein encoded by HTLV-1 has never been reported until now.
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Cites
Nuclear protein CBP is a coactivator for the transcription factor CREB
Kwok, R. P. S., Lundblad, J. R., Chrivia, J. C., Richards, J. P., Bächinger, H. P., Brennan, R. G., Roberts, S. G. E., Green, M. R., & Goodman, R. H. (1994) · Nature · doi:10.1038/370223a0 · Cited by 1,443
Suzuki, T., Fujisawa, J. I., Toita, M., & Yoshida, M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.610 · Cited by 256
Cited by
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation
Matsuoka, M., & Jeang, K.-T. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2111 · Cited by 829
Human T-lymphotropic virus 1: recent knowledge about an ancient infection
Verdonck, K., González, E., Van Dooren, S., Vandamme, A.-M., Vanham, G., & Gotuzzo, E. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70081-6 · Cited by 661
HTLV-1 bZIP Factor Induces T-Cell Lymphoma and Systemic Inflammation In Vivo
Satou, Y., Yasunaga, J.-I., Zhao, T., Yoshida, M., Miyazato, P., Takai, K., Shimizu, K., Ohshima, K., Green, P. L., Ohkura, N., et al. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001274 · Cited by 319
Silencing of human T-cell leukemia virus type I gene transcription by epigenetic mechanisms
Taniguchi, Y., Nosaka, K., Yasunaga, J.-I., Maeda, M., Mueller, N., Okayama, A., & Matsuoka, M. (2005) · Retrovirology · doi:10.1186/1742-4690-2-64 · Cited by 209
Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferation
Arnold, J., Zimmerman, B., Li, M., Lairmore, M. D., & Green, P. L. (2008) · Blood · doi:10.1182/blood-2008-04-154286 · Cited by 207
Metadata
- Authors
- Gaudray, G., Gachon, F., Basbous, J., Biard-Piechaczyk, M., Devaux, C., & Mesnard, J.-M.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2002-12-15
- Volume
- 76
- Issue
- 24
- Pages
- 12813-12822
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2171479458
- Cited by
- 506
- References
- 2
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- green
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