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The Complementary Strand of the Human T-Cell Leukemia Virus Type 1 RNA Genome Encodes a bZIP Transcription Factor That Down-Regulates Viral Transcription
Open accessAbstract
The RNA genome of the human T-cell leukemia virus type 1 (HTLV-1) codes for proteins involved in infectivity, replication, and transformation. We report in this study the characterization of a novel viral protein encoded by the complementary strand of the HTLV-1 RNA genome. This protein, designated HBZ (for HTLV-1 bZIP factor), contains a N-terminal transcriptional activation domain and a leucine zipper motif in its C terminus. We show here that HBZ is able to interact with the bZIP transcription factor CREB-2 (also called ATF-4), known to activate the HTLV-1 transcription by recruiting the viral trans -activator Tax on the Tax-responsive elements (TxREs). However, we demonstrate that the HBZ/CREB-2 heterodimers are no more able to bind to the TxRE and cyclic AMP response element sites. Taking these findings together, the functional inactivation of CREB-2 by HBZ is suggested to contribute to regulation of the HTLV-1 transcription. Moreover, the characterization of a minus-strand gene protein encoded by HTLV-1 has never been reported until now.
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Nuclear protein CBP is a coactivator for the transcription factor CREB
Kwok, R. P. S., Lundblad, J. R., Chrivia, J. C., Richards, J. P., Bächinger, H. P., Brennan, R. G., Roberts, S. G. E., Green, M. R., & Goodman, R. H. (1994) · Nature · doi:10.1038/370223a0 · Cited by 1,443
Suzuki, T., Fujisawa, J. I., Toita, M., & Yoshida, M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.610 · Cited by 256
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Human T-lymphotropic virus 1: recent knowledge about an ancient infection
Verdonck, K., González, E., Van Dooren, S., Vandamme, A.-M., Vanham, G., & Gotuzzo, E. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70081-6 · Cited by 661
HTLV-1 bZIP Factor Induces T-Cell Lymphoma and Systemic Inflammation In Vivo
Satou, Y., Yasunaga, J.-I., Zhao, T., Yoshida, M., Miyazato, P., Takai, K., Shimizu, K., Ohshima, K., Green, P. L., Ohkura, N., et al. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001274 · Cited by 319
Silencing of human T-cell leukemia virus type I gene transcription by epigenetic mechanisms
Taniguchi, Y., Nosaka, K., Yasunaga, J.-I., Maeda, M., Mueller, N., Okayama, A., & Matsuoka, M. (2005) · Retrovirology · doi:10.1186/1742-4690-2-64 · Cited by 209
Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferation
Arnold, J., Zimmerman, B., Li, M., Lairmore, M. D., & Green, P. L. (2008) · Blood · doi:10.1182/blood-2008-04-154286 · Cited by 207
Arnold, J., Yamamoto, B., Li, M., Phipps, A. J., Younis, I., Lairmore, M. D., & Green, P. L. (2006) · Blood · doi:10.1182/blood-2005-11-4551 · Cited by 196
Saito, M., Matsuzaki, T., Satou, Y., Yasunaga, J.-I., Saito, K., Arimura, K., Matsuoka, M., & Ohara, Y. (2009) · Retrovirology · doi:10.1186/1742-4690-6-19 · Cited by 184
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Van Prooyen, N., Gold, H., Andresen, V., Schwartz, O., Jones, K., Ruscetti, F., Lockett, S., Gudla, P., Venzon, D., & Franchini, G. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009635107 · Cited by 178
HTLV Tax: A Fascinating Multifunctional Co-Regulator of Viral and Cellular Pathways
Currer, R., Van Duyne, R., Jaworski, E., Guendel, I., Sampey, G., Das, R., Narayanan, A., & Kashanchi, F. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00406 · Cited by 156
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Kannian, P., & Green, P. L. (2010) · Viruses · doi:10.3390/v2092037 · Cited by 139
APOBEC3G Generates Nonsense Mutations in Human T-Cell Leukemia Virus Type 1 Proviral Genomes In Vivo
Fan, J., Ma, G., Nosaka, K., Tanabe, J., Satou, Y., Koito, A., Wain-Hobson, S., Vartanian, J.-P., & Matsuoka, M. (2010) · Journal of Virology · doi:10.1128/jvi.02239-09 · Cited by 130
Usui, T., Yanagihara, K., Tsukasaki, K., Murata, K., Hasegawa, H., Yamada, Y., & Kamihira, S. (2008) · Retrovirology · doi:10.1186/1742-4690-5-34 · Cited by 127
Characterization of Human Endogenous Retroviral Elements in the Blood of HIV-1-Infected Individuals
Contreras-Galindo, R., Kaplan, M. H., Contreras-Galindo, A. C., Gonzalez-Hernandez, M. J., Ferlenghi, I., Giusti, F., Lorenzo, E., Gitlin, S. D., Dosik, M. H., Yamamura, Y., et al. (2012) · Journal of Virology · doi:10.1128/jvi.00602-11 · Cited by 103
Nuclear localization of HTLV-I bZIP factor (HBZ) is mediated by three distinct motifs
Hivin, P., Frédéric, M., Arpin-André, C., Basbous, J., Gay, B., Thébault, S., & Mesnard, J.-M. (2005) · Journal of Cell Science · doi:10.1242/jcs.01727 · Cited by 92
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Enose-Akahata, Y., Vellucci, A., & Jacobson, S. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02563 · Cited by 88
Gazon, H., Lemasson, I., Polakowski, N., Césaire, R., Matsuoka, M., Barbeau, B., Mesnard, J.-M., & Peloponese, J.-M. (2012) · Journal of Virology · doi:10.1128/jvi.00661-12 · Cited by 73
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Hoshino, H. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00222 · Cited by 58
Baratella, M., Forlani, G., Raval, G. U., Tedeschi, A., Gout, O., Gessain, A., Tosi, G., & Accolla, R. S. (2017) · PLOS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0005285 · Cited by 42
Panfil, A. R., Dissinger, N. J., Howard, C. M., Murphy, B. M., Landes, K., Fernandez, S. A., & Green, P. L. (2016) · Journal of Virology · doi:10.1128/jvi.03113-15 · Cited by 39
Hleihel, R., Skayneh, H., de Thé, H., Hermine, O., & Bazarbachi, A. (2023) · Blood Cancer Journal · doi:10.1038/s41408-023-00841-7 · Cited by 31
Andrade, R. G., Gonçalves, P. D. C., Ribeiro, M. A., Romanelli, L. C. F., Ribas, J. G., Torres, E. B., Carneiro-Proietti, A. B. D. F., Barbosa-Stancioli, E. F., & Martins, M. L. (2013) · Journal of Clinical Virology · doi:10.1016/j.jcv.2012.10.003 · Cited by 29
Current State of Therapeutics for HTLV-1
Wang, T. T., Hirons, A., Doerflinger, M., Morris, K. V., Ledger, S., Purcell, D. F. J., Kelleher, A. D., & Ahlenstiel, C. L. (2024) · Viruses · doi:10.3390/v16101616 · Cited by 22
In vivo antagonistic role of the Human T-Cell Leukemia Virus Type 1 regulatory proteins Tax and HBZ
Akkouche, A., Moodad, S., Hleihel, R., Skayneh, H., Chambeyron, S., El Hajj, H., & Bazarbachi, A. (2021) · PLOS Pathogens · doi:10.1371/journal.ppat.1009219 · Cited by 20
High level of genomic divergence in orf-I p12 and hbz genes of HTLV-1 subtype-C in Central Australia
Hirons, A., Yurick, D., Jansz, N., Ellenberg, P., Franchini, G., Einsiedel, L., Khoury, G., & Purcell, D. F. J. (2024) · Retrovirology · doi:10.1186/s12977-024-00647-w · Cited by 13
Noncoding RNAs in Retrovirus Replication
Duchon, A. A., & Musier-Forsyth, K. (2018) · Retrovirus-Cell Interactions · doi:10.1016/b978-0-12-811185-7.00012-1 · Cited by 1
Metadata
- Authors
- Gaudray, G., Gachon, F., Basbous, J., Biard-Piechaczyk, M., Devaux, C., & Mesnard, J.-M.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2002-12-15
- Volume
- 76
- Issue
- 24
- Pages
- 12813-12822
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2171479458
- Cited by
- 506
- References
- 2
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- green
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