Human Effector and Memory CD8+ T Cell Responses to Smallpox and Yellow Fever Vaccines

Miller, Joseph D.; van der Most, Robbert G.; Akondy, Rama S.; Glidewell, John T.; Albott, Sophia; Masopust, David; Murali-Krishna, Kaja; Mahar, Patryce L.; Edupuganti, Srilatha; Lalor, Susan; Germon, Stephanie; Del Rio, Carlos; Mulligan, Mark J.; Staprans, Silvija I.; Altman, John D.; Feinberg, Mark B.; Ahmed, Rafi

doi:10.1016/j.immuni.2008.02.020

Cited by 601T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune responses and vaccinations

Human Effector and Memory CD8+ T Cell Responses to Smallpox and Yellow Fever Vaccines

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Miller, Joseph D., van der Most, Robbert G., Akondy, Rama S., Glidewell, John T., Albott, Sophia, Masopust, David, Murali-Krishna, Kaja, Mahar, Patryce L. +9 more·2008·Immunity

DOI 10.1016/j.immuni.2008.02.020

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Abstract

To explore the human T cell response to acute viral infection, we performed a longitudinal analysis of CD8(+) T cells responding to the live yellow fever virus and smallpox vaccines--two highly successful human vaccines. Our results show that both vaccines generated a brisk primary effector CD8(+) T cell response of substantial magnitude that could be readily quantitated with a simple set of four phenotypic markers. Secondly, the vaccine-induced T cell response was highly specific with minimal bystander effects. Thirdly, virus-specific CD8(+) T cells passed through an obligate effector phase, contracted more than 90% and gradually differentiated into long-lived memory cells. Finally, these memory cells were highly functional and underwent a memory differentiation program distinct from that described for human CD8(+) T cells specific for persistent viruses. These results provide a benchmark for CD8(+) T cell responses induced by two of the most effective vaccines ever developed.

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Timepoints were chosen a priori to capture the peak antigen-specific response for primary and secondary responses in SARS-CoV-2 naïve individuals.
“Timepoints were chosen a priori to capture the peak antigen-specific response for primary (41) and secondary responses (42, 43) in SARS-CoV-2 naïve individuals.”
From Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination (2021) · cites this paper as [41]

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Authors: Miller, J. D., van der Most, R. G., Akondy, R. S., Glidewell, J. T., Albott, S., Masopust, D., Murali-Krishna, K., Mahar, P. L., Edupuganti, S., Lalor, S., Germon, S., Del Rio, C., Mulligan, M. J., Staprans, S. I., Altman, J. D., Feinberg, M. B., & Ahmed, R.
Affiliations: Emory University (US)
Corresponding author: Ahmed, Rafi
ORCID: Akondy, Rama S.
Masopust, David
Edupuganti, Srilatha
Mulligan, Mark J.
Altman, John D.
Feinberg, Mark B.
Ahmed, Rafi
Venue: Immunity
Publisher: Elsevier BV
Published: 2008-05
Volume: 28
Issue: 5
Pages: 710-722
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2008.02.020
OpenAlex: W2171633892
Cited by: 601
References: 72
Citations by year: 2026: 12 · 2025: 24 · 2024: 17 · 2023: 28 · 2022: 22 · 2021: 54 · 2020: 36 · 2019: 32 · 2018: 26 · 2017: 41 · 2016: 34 · 2015: 40 · 2014: 31 · 2013: 42 · 2012: 39
FWCI: 17.10
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1903 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: CD8+ T cells, smallpox vaccine, yellow fever vaccine, effector T cells, memory T cells, T cell differentiation, bystander effect, vaccine-induced immunity, viral infection, live attenuated virus vaccine
MeSH terms: B-Lymphocytes, T-Lymphocytes, Helper-Inducer, Humans, Immunologic Memory, Lymphocyte Activation, Smallpox Vaccine, Vaccination, Vaccinia virus, Histocompatibility Antigens Class I, CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets, CD8-Positive T-Lymphocytes, Yellow Fever Vaccine

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Human Effector and Memory CD8+ T Cell Responses to Smallpox and Yellow Fever Vaccines

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