The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2
Open accessAbstract
Human cytomegalovirus (CMV) is a ubiquitous opportunistic pathogen that causes significant morbidity and mortality in immuncompromised people. An understanding of how CMV induces and circumvents host immunity is of critical importance in efforts to design effective therapeutics. It was recently discovered that mere cell contact by CMV particles leads to profound modulation of cellular gene expression, including induction of inflammatory cytokines and interferon-stimulated genes characteristic of innate immune detection. These findings suggest that a membrane receptor recognizes a CMV envelope protein(s), leading to innate immune activation. Here, we show that the pattern recognition receptors Toll-like receptor 2 (TLR2) and CD14 recognize CMV virions and trigger inflammatory cytokine production. Induction of inflammatory cytokines is mediated via TLR2-dependent activation of NF-κB. Since many of the pathological processes associated with CMV disease are facilitated or directly mediated by inflammatory cytokines, identification of the host membrane detection machinery may ultimately lead to improved therapeutics.
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Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
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Toll-like Receptor 4 Polymorphisms and Atherogenesis
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Viral Subversion of the Immune System
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The Toll receptor family and microbial recognition
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Cited by
Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,952
Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs
Olson, J. K., & Miller, S. D. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.6.3916 · Cited by 1,215
Toll-like receptors and innate immunity
Uematsu, S., & Akira, S. (2006) · Journal of Molecular Medicine · doi:10.1007/s00109-006-0084-y · Cited by 441
Zähringer, U., Lindner, B., Inamura, S., Heine, H., & Alexander, C. (2008) · Immunobiology · doi:10.1016/j.imbio.2008.02.005 · Cited by 403
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Metadata
- Authors
- Compton, T., Kurt-Jones, E. A., Boehme, K. W., Belko, J., Latz, E., Golenbock, D. T., & Finberg, R. W.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2003-04-15
- Volume
- 77
- Issue
- 8
- Pages
- 4588-4596
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2133369735
- Cited by
- 676
- References
- 62
- FWCI
- 33.63
- Type
- journal article
- Language
- en
- Open access
- green
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- Compton, T., Kurt-Jones, E. A., Boehme, K. W., Belko, J., Latz, E., Golenbock, D. T., & Finberg, R. W. (2003). Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2. Journal of Virology. https://doi.org/10.1128/jvi.77.8.4588-4596.2003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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