The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Interferon-Dependent Immunity Is Essential for Resistance to Primary Dengue Virus Infection in Mice, Whereas T- and B-Cell-Dependent Immunity Are Less Critical
Open accessAbstract
Dengue virus (DEN) causes dengue fever and dengue hemorrhagic fever/dengue shock syndrome, which are major public health problems worldwide. The immune factors that control DEN infection or contribute to severe disease are neither well understood nor easy to examine in humans. In this study, we used wild-type and congenic mice lacking various components of the immune system to study the immune mechanisms in the response to DEN infection. Our results demonstrate that alpha/beta interferon (IFN-α/β) and IFN-γ receptors have critical, nonoverlapping functions in resolving primary DEN infection. Furthermore, we show that IFN-α/β receptor-mediated action limits initial DEN replication in extraneural sites and controls subsequent viral spread into the central nervous system (CNS). In contrast, IFN-γ receptor-mediated responses seem to act at later stages of DEN disease by restricting viral replication in the periphery and eliminating virus from the CNS. Mice deficient in B, CD4 + T, or CD8 + T cells had no increased susceptibility to DEN; however, RAG mice (deficient in both B and T cells) were partially susceptible to DEN infection. In summary, (i) IFN-α/β is critical for early immune responses to DEN infection, (ii) IFN-γ-mediated immune responses are crucial for both early and late clearance of DEN infection in mice, and (iii) the IFN system plays a more important role than T- and B-cell-dependent immunity in resistance to primary DEN infection in mice.
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Cites
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Metadata
- Authors
- Shresta, S., Kyle, J. L., Snider, H. M., Basavapatna, M., Beatty, P. R., & Harris, E.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2004-03-15
- Volume
- 78
- Issue
- 6
- Pages
- 2701-2710
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2118830863
- Cited by
- 320
- References
- 43
- FWCI
- 12.13
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Interferon-Dependent Immunity Is Essential for Resistance to Primary Dengue Virus Infection in Mice, Whereas T- and B-Cell-Dependent Immunity Are Less Critical. https://app.cochat.ai/papers/10.1128/jvi.78.6.2701-2710.2004
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- Shresta, S., Kyle, J. L., Snider, H. M., Basavapatna, M., Beatty, P. R., & Harris, E. (2004). Interferon-Dependent Immunity Is Essential for Resistance to Primary Dengue Virus Infection in Mice, Whereas T- and B-Cell-Dependent Immunity Are Less Critical. Journal of Virology. https://doi.org/10.1128/jvi.78.6.2701-2710.2004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
