Equine herpesvirus 1 utilizes a novel herpesvirus entry receptor.

Frampton, Arthur R.; Goins, William F.; Cohen, Justus B.; von Einem, Jens; Osterrieder, Nikolaus; O'Callaghan, Dennis J.; Glorioso, Joseph C.

doi:10.1128/jvi.79.5.3169-3173.2005

Cited by 36Herpesvirus Infections and TreatmentsAnimal Virus Infections StudiesCytomegalovirus and herpesvirus research

Equine herpesvirus 1 utilizes a novel herpesvirus entry receptor.

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Frampton, Arthur R., Goins, William F., Cohen, Justus B., von Einem, Jens, Osterrieder, Nikolaus, O'Callaghan, Dennis J., Glorioso, Joseph C.·2005·Journal of Virology

DOI 10.1128/jvi.79.5.3169-3173.2005PMC PMC548480

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Abstract

The well-described herpesvirus entry receptors HveA (TNFRSF14), HveB (nectin 2), and HveC (nectin 1) have been shown to mediate the entry of alphaherpesviruses. Our findings showed that the alphaherpesvirus equine herpesvirus 1 (EHV-1) efficiently entered and replicated in CHO-K1 cells that lack the entry receptors HveA, HveB, and HveC, demonstrating that EHV-1 utilizes a unique entry receptor. As with other alphaherpesviruses, efficient EHV-1 entry was dependent on glycoprotein D and cell surface glycosaminoglycans.

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EHV-1 uses a cell surface receptor that is distinct from any of the known alphaherpesvirus entry receptors.
“Previous studies have already shown that EHV-1 uses a cell surface receptor that is distinct from any of the known alphaherpesvirus entry receptors (Frampton et al., 2005).”
From The Pathogenesis and Immune Evasive Mechanisms of Equine Herpesvirus Type 1 (2021) · cites this paper as Frampton et al., 2005

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Equine Herpesvirus 1 Entry via Endocytosis Is Facilitated by αV Integrins and an RSD Motif in Glycoprotein D
Van de Walle, G. R., Peters, S. T., VanderVen, B. C., O'Callaghan, D. J., & Osterrieder, N. (2008) · Journal of Virology · doi:10.1128/jvi.00868-08 · Cited by 54 · see citing works
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Glycoprotein H and α4β1 Integrins Determine the Entry Pathway of Alphaherpesviruses
Azab, W., Lehmann, M. J., & Osterrieder, N. (2013) · Journal of Virology · doi:10.1128/jvi.03522-12 · Cited by 32 · see citing works
Glycoproteins D of equine herpesvirus type 1 (EHV-1) and EHV-4 determine cellular tropism independently of integrins
Azab, W., & Osterrieder, N. (2012) · Journal of Virology · doi:10.1128/jvi.06555-11 · Cited by 49 · see citing works
<i>Equus caballus</i> Major Histocompatibility Complex Class I Is an Entry Receptor for Equine Herpesvirus Type 1
Kurtz, B. M., Singletary, L. B., Kelly, S. D., & Frampton, A. R. (2010) · Journal of Virology · doi:10.1128/jvi.00287-10 · Cited by 44 · see citing works

Authors: Frampton, A. R., Goins, W. F., Cohen, J. B., von Einem, J., Osterrieder, N., O'Callaghan, D. J., & Glorioso, J. C.
Affiliations: University of Pittsburgh (US)
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York
Cornell University (US)
Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana
ORCID: Frampton, Arthur R.
Goins, William F.
Cohen, Justus B.
Osterrieder, Nikolaus
Glorioso, Joseph C.
Venue: Journal of Virology
Publisher: American Society for Microbiology
Published: 2005-03
Volume: 79
Issue: 5
Pages: 3169-3173
ISSN: 0022-538X (ISSN-L)
1098-5514
DOI: 10.1128/jvi.79.5.3169-3173.2005
PMC: PMC548480
OpenAlex: W2117140759
Cited by: 36
References: 26
Citations by year: 2026: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 3 · 2019: 2 · 2017: 3 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 1
FWCI: 2.15
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Virology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p20rr018724-07, R01‐grant, HL66949)
National Heart, Lung, and Blood Institute (U01HL066949)
National Institute of Allergy and Infectious Diseases (AI 22001, R01AI022001)
National Institute of Neurological Disorders and Stroke (R01NS044323, NS044323)
National Center for Research Resources (P20-RR018724)
Topics: Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Keywords: equine herpesvirus 1, alphaherpesvirus, viral entry receptor, glycoprotein D, cell surface glycosaminoglycans, nectin-2, nectin-1, CHO-K1 cells, viral entry
MeSH terms: Animals, Chlorocebus aethiops, Herpesvirus 1, Equid, Glycosaminoglycans, Cricetinae, Herpesviridae Infections, Horse Diseases, Horses, Receptors, Virus, Vero Cells, Viral Envelope Proteins, CHO Cells

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Equine herpesvirus 1 utilizes a novel herpesvirus entry receptor.

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