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Cited by 21Bacterial Genetics and BiotechnologyMicrobial Metabolic Engineering and BioproductionBacterial biofilms and quorum sensing

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Systems-Wide Dissection of Organic Acid Assimilation in Pseudomonas aeruginosa Reveals a Novel Path To Underground Metabolism

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Dolan, Stephen K., Wijaya, Andre, Kohlstedt, Michael, Gläser, Lars, Brear, Paul, Silva-Rocha, Rafael, Wittmann, Christoph, Welch, Martin·2022·mBio
DOI 10.1128/mbio.02541-22PMC PMC9765439

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Abstract

Pseudomonas aeruginosa is an opportunistic human pathogen that, due to its unrivalled resistance to antibiotics, ubiquity in the built environment, and aggressiveness in infection scenarios, has acquired the somewhat dubious accolade of being designated a “critical priority pathogen” by the WHO. In this work, we uncover the pathways and mechanisms used by P. aeruginosa to grow on a substrate that is abundant at many infection sites: propionate.

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Metadata

Authors
Dolan, S. K., Wijaya, A., Kohlstedt, M., Gläser, L., Brear, P., Silva-Rocha, R., Wittmann, C., & Welch, M.
Affiliations
  • Georgia Institute of Technology (US)
  • University of Dundee (GB)
  • Saarland University (DE)
  • University of Cambridge (GB)
  • Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil
Corresponding author
  • Dolan, Stephen K.
  • Welch, Martin
ORCID
Venue
mBio
Publisher
American Society for Microbiology
Published
2022-12-20
Volume
13
Issue
6
Pages
e0254122-e0254122
ISSN
2150-7511 (ISSN-L)
DOI
10.1128/mbio.02541-22
PMC
PMC9765439
OpenAlex
W4309048142
Cited by
21
References
2
Citations by year
2026: 2 · 2025: 6 · 2024: 9 · 2023: 4
FWCI
3.01
Type
journal article
Language
en
Open access
Licence
Locations
  • mBio (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Discovery Research Portal (University of Dundee) (submittedVersion, cc-by)
  • Apollo (University of Cambridge) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Apollo (cc-by)
Funders
  • Bundesministerium für Bildung und Forschung (FKZ 03V0757, FKZ 031B0344A)
  • Deutsche Forschungsgemeinschaft (WI-1796/4-1)
  • UKRI | Biotechnology and Biological Sciences Research Council (BB/M019411/1, BB/R005435/1/FAPESP)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Keywords
Pseudomonas aeruginosa, propionate metabolism, cellular prion protein, citrate synthase, moonlighting enzymes, bacterial metabolism, antibiotic resistance, opportunistic pathogens
MeSH terms
Citrate (si)-Synthase, Humans, Kinetics, Propionates, Pseudomonas aeruginosa, Pseudomonas Infections, Transcription Factors

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