The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Mir-17-5p Regulates Breast Cancer Cell Proliferation by Inhibiting Translation of AIB1 mRNA
Open accessAbstract
MicroRNAs are an extensive family of approximately 22-nucleotide-long noncoding RNAs expressed in a wide range of eukaryotes, including humans, and they are important in development and disease. We found that microRNA Mir-17-5p has extensive complementarity to the mRNA of AIB1 (named for "amplified in breast cancer 1"). Cell culture experiments showed that AIB1 expression was downregulated by Mir-17-5p, primarily through translational inhibition. Expression of Mir-17-5p was low in breast cancer cell lines. We also found that downregulation of AIB1 by Mir-17-5p resulted in decreased estrogen receptor-mediated, as well as estrogen receptor-independent, gene expression and decreased proliferation of breast cancer cells. Mir-17-5p also completely abrogated the insulin-like growth factor 1-mediated, anchorage-independent growth of breast cancer cells. Our results reveal that Mir-17-5p has a role as a tumor suppressor in breast cancer cells.
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A pancreatic islet-specific microRNA regulates insulin secretion
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miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
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Cited by
Garzon, R., Calin, G. A., & Croce, C. M. (2009) · Annual Review of Medicine · doi:10.1146/annurev.med.59.053006.104707 · Cited by 1,770
MicroRNA: Biogenesis, Function and Role in Cancer
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MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression
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Aspects of the Tumor Microenvironment Involved in Immune Resistance and Drug Resistance
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Metadata
- Authors
- Hossain, A., Kuo, M. T., & Saunders, G. F.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2006-11-01
- Volume
- 26
- Issue
- 21
- Pages
- 8191-8201
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2132531407
- Cited by
- 511
- References
- 8
- FWCI
- 11.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Hossain, A., Kuo, M. T., & Saunders, G. F. (2006). Mir-17-5p Regulates Breast Cancer Cell Proliferation by Inhibiting Translation of AIB1 mRNA. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.00242-06
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