The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
DNA Damage-Dependent Acetylation and Ubiquitination of H2AX Enhances Chromatin Dynamics
Open accessAbstract
Chromatin reorganization plays an important role in DNA repair, apoptosis, and cell cycle checkpoints. Among proteins involved in chromatin reorganization, TIP60 histone acetyltransferase has been shown to play a role in DNA repair and apoptosis. However, how TIP60 regulates chromatin reorganization in the response of human cells to DNA damage is largely unknown. Here, we show that ionizing irradiation induces TIP60 acetylation of histone H2AX, a variant form of H2A known to be phosphorylated following DNA damage. Furthermore, TIP60 regulates the ubiquitination of H2AX via the ubiquitin-conjugating enzyme UBC13, which is induced by DNA damage. This ubiquitination of H2AX requires its prior acetylation. We also demonstrate that acetylation-dependent ubiquitination by the TIP60-UBC13 complex leads to the release of H2AX from damaged chromatin. We conclude that the sequential acetylation and ubiquitination of H2AX by TIP60-UBC13 promote enhanced histone dynamics, which in turn stimulate a DNA damage response.
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Cites
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Cited by
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-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin
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Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
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ATP-dependent chromatin remodeling: genetics, genomics and mechanisms
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Metadata
- Authors
- Ikura, T., Tashiro, S., Kakino, A., Shima, H., Jacob, N., Amunugama, R., Yoder, K., Izumi, S., Kuraoka, I., Tanaka, K., Kimura, H., Ikura, M., Nishikubo, S., Ito, T., Muto, A., Miyagawa, K., Takeda, S., Fishel, R., Igarashi, K., & Kamiya, K.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2007-10-01
- Volume
- 27
- Issue
- 20
- Pages
- 7028-7040
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2008686279
- Cited by
- 376
- References
- 12
- FWCI
- 11.02
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: DNA Damage-Dependent Acetylation and Ubiquitination of H2AX Enhances Chromatin Dynamics. https://app.cochat.ai/papers/10.1128/mcb.00579-07
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- Ikura, T., Tashiro, S., Kakino, A., Shima, H., Jacob, N., Amunugama, R., Yoder, K., Izumi, S., Kuraoka, I., Tanaka, K., Kimura, H., Ikura, M., Nishikubo, S., Ito, T., Muto, A., Miyagawa, K., Takeda, S., Fishel, R., Igarashi, K., & Kamiya, K. (2007). DNA Damage-Dependent Acetylation and Ubiquitination of H2AX Enhances Chromatin Dynamics. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.00579-07
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
