Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response
Open accessAbstract
The BRCT repeats of the breast and ovarian cancer predisposition protein BRCA1 are essential for tumor suppression. Phosphopeptide affinity proteomic analysis identified a protein, Abraxas, that directly binds the BRCA1 BRCT repeats through a phospho-Ser-X-X-Phe motif. Abraxas binds BRCA1 to the mutual exclusion of BACH1 (BRCA1-associated C-terminal helicase) and CtIP (CtBP-interacting protein), forming a third type of BRCA1 complex. Abraxas recruits the ubiquitin-interacting motif (UIM)–containing protein RAP80 to BRCA1. Both Abraxas and RAP80 were required for DNA damage resistance, G 2 -M checkpoint control, and DNA repair. RAP80 was required for optimal accumulation of BRCA1 on damaged DNA (foci) in response to ionizing radiation, and the UIM domains alone were capable of foci formation. The RAP80-Abraxas complex may help recruit BRCA1 to DNA damage sites in part through recognition of ubiquitinated proteins.
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CTIP and ABRA1/Abraxas contain phospho-SXXF motifs that mediate direct interaction with BRCA1-BRCTs.
“In addition to FANCJ, several proteins, including CTIP and ABRA1/Abraxas, have phospho-SXXF motifs (S is serine, F is phenylalanine and X varies) that mediate the direct interaction with the BRCA1-BRCTs, which are phospho-binding motifs [37–40].”
From Hereditary Breast Cancer and the BRCA1-Associated FANCJ/BACH1/BRIP1 (2011) · cites this paper as [38]
FANCJ mediates a subset of BRCA1 functions in double-strand break repair.
“Using a DNA double-strand break-induced recombination assay [75], siRNA depletion of FANCJ was shown to substantially [26] or partially reduce homologous recombination [38], supporting the idea that FANCJ mediates a subset of BRCA1 functions in double-strand break repair.”
From Hereditary Breast Cancer and the BRCA1-Associated FANCJ/BACH1/BRIP1 (2011) · cites this paper as [38]
siRNA depletion of FANCJ substantially or partially reduced homologous recombination.
“Using a DNA double-strand break-induced recombination assay [75], siRNA depletion of FANCJ was shown to substantially [26] or partially reduce homologous recombination [38], supporting the idea that FANCJ mediates a subset of BRCA1 functions in double-strand break repair.”
From Hereditary Breast Cancer and the BRCA1-Associated FANCJ/BACH1/BRIP1 (2011) · cites this paper as [38]
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- Authors
- Wang, B., Matsuoka, S., Ballif, B. A., Zhang, D., Smogorzewska, A., Gygi, S. P., & Elledge, S. J.
- Affiliations
- Brigham and Women's Hospital (US)
- University of Vermont (US)
- Corresponding author
- Ballif, Bryan A.
- Zhang, Dong
- Elledge, Stephen J.
- Venue
- Science
- Published
- 2007-05-25
- Volume
- 316
- Issue
- 5828
- Pages
- 1194-1198
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3573690
- OpenAlex
- W1989800108
- Cited by
- 695
- References
- 30
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 12 · 2023: 18 · 2022: 19 · 2021: 37 · 2020: 33 · 2019: 35 · 2018: 21 · 2017: 35 · 2016: 31 · 2015: 33 · 2014: 40 · 2013: 52 · 2012: 69
- FWCI
- 23.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- U.S. Public Health Service (1U19A1067751)
- National Cancer Institute (T32CA09216, CA116275-01, K01CA116275, T32CA009216)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Keywords
- BRCA1, Abraxas, RAP80, DNA damage response, ubiquitin-interacting motif, BACH1, CtIP, G2/M checkpoint, DNA repair, ionizing radiation, protein complex formation, ubiquitinated proteins
- MeSH terms
- Amino Acid Sequence, Carrier Proteins, DNA Damage, DNA Repair, DNA-Binding Proteins, Endodeoxyribonucleases, HeLa Cells, Humans, Molecular Sequence Data, Nuclear Proteins, Protein Binding, Mass Spectrometry, Protein Structure, Tertiary, BRCA1 Protein, Cell Line, Tumor, Histone Chaperones
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