The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-Myc
Open accessAbstract
Inhibition of the mutationally activated Wnt cascade in colorectal cancer cell lines induces a rapid G1 arrest and subsequent differentiation. This arrest can be overcome by maintaining expression of a single Tcf4 target gene, the proto-oncogene c-Myc. Since colorectal cancer cells share many molecular characteristics with proliferative crypt progenitors, we have assessed the physiological role of c-Myc in adult crypts by conditional gene deletion. c-Myc-deficient crypts are lost within weeks and replaced by c-Myc-proficient crypts through a fission process of crypts that have escaped gene deletion. Although c-Myc(-/-) crypt cells remain in the cell cycle, they are on average much smaller than wild-type cells, cycle slower, and divide at a smaller cell size. c-Myc appears essential for crypt progenitor cells to provide the necessary biosynthetic capacity to successfully progress through the cell cycle.
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Zanet, J., Pibre, S., Jacquet, C., Ramirez, A., de Alborán, I. M., & Gandarillas, A. (2005) · Journal of Cell Science · doi:10.1242/jcs.02298 · Cited by 123
c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver
Baena, E., Gandarillas, A., Vallespinós, M., Zanet, J., Bachs, O., Redondo, C., Fabregat, I., Martinez-A., C., & de Alborán, I. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409260102 · Cited by 104
Cited by
Identification of stem cells in small intestine and colon by marker gene Lgr5
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687
Self-citationThe intestinal crypt, a prototype stem cell compartment
Clevers, H. (2013) · Cell · doi:10.1016/j.cell.2013.07.004 · Cited by 1,223
Self-citationA reserve stem cell population in small intestine renders Lgr5-positive cells dispensable
Tian, H., Biehs, B., Warming, S., Leong, K. G., Rangell, L., Klein, O. D., & de Sauvage, F. J. (2011) · Nature · doi:10.1038/nature10408 · Cited by 1,204
Wnt/β-Catenin Is Essential for Intestinal Homeostasis and Maintenance of Intestinal Stem Cells
Fevr, T., Robine, S., Louvard, D., & Huelsken, J. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01034-07 · Cited by 649
Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas
Schaub, F. X., Dhankani, V., Berger, A. C., Trivedi, M., Richardson, A. B., Shaw, R., Zhao, W., Zhang, X., Ventura, A., Liu, Y., et al. (2018) · Cell Systems · doi:10.1016/j.cels.2018.03.003 · Cited by 431
“…al., 2000; Hemann et al., 2005); (2) mutation or rare amplification of distal enhancers (Sur et al., 2012; Zhang et al., 2016); and (3) activating mutations in signal transduction pathways (e.g., Wnt, Notch) that augment MYC expression (Herranz et al., 2014; Muncan et al., 2006; Weng et al., 2006).”
Metadata
- Authors
- Muncan, V., Sansom, O. J., Tertoolen, L., Phesse, T. J., Begthel, H., Sancho, E., Cole, A. M., Gregorieff, A., de Alboran, I. M., Clevers, H., & Clarke, A. R.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2006-11-01
- Volume
- 26
- Issue
- 22
- Pages
- 8418-8426
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2151436498
- Cited by
- 248
- References
- 2
- FWCI
- 7.37
- Type
- journal article
- Language
- en
- Open access
- green
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- Muncan, V., Sansom, O. J., Tertoolen, L., Phesse, T. J., Begthel, H., Sancho, E., Cole, A. M., Gregorieff, A., de Alboran, I. M., Clevers, H., & Clarke, A. R. (2006). Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-Myc. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.00821-06
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
