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Activation of BRCA1/BRCA2-Associated Helicase BACH1 Is Required for Timely Progression through S Phase
Open accessAbstract
BACH1 (also known as FANCJ and BRIP1) is a DNA helicase that directly interacts with the C-terminal BRCT repeat of the breast cancer susceptibility protein BRCA1. Previous biochemical and functional analyses have suggested a role for the BACH1 homolog in Caenorhabditis elegans during DNA replication. Here, we report the association of BACH1 with a distinct BRCA1/BRCA2-containing complex during the S phase of the cell cycle. Depletion of BACH1 or BRCA1 using small interfering RNAs results in delayed entry into the S phase of the cell cycle. Such timely progression through S phase requires the helicase activity of BACH1. Importantly, cells expressing a dominant negative mutation in BACH1 that results in a defective helicase displayed increased activation of DNA damage checkpoints and genomic instability. BACH1 helicase is silenced during the G(1) phase of the cell cycle and is activated through a dephosphorylation event as cells enter S phase. These results point to a critical role for BACH1 helicase activity not only in the timely progression through the S phase but also in maintaining genomic stability.
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“FANCJ helicase activity induced in S phase is also required for FANCJ to promote S phase progression and possibly intra-S phase checkpoints [71,72].”
From Hereditary Breast Cancer and the BRCA1-Associated FANCJ/BACH1/BRIP1 (2011) · cites this paper as [71]
Citations
Cites
A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1
Miki, Y., Swensen, J. J., Shattuck-Eidens, D. M., Futreal, P. A., Harshman, K., Tavtigian, S. V., Liu, Q., Cochran, C., Bennett, L. M., Ding, W., et al. (1994) · Science · doi:10.1126/science.7545954 · Cited by 6,069
BRCA1 mutations in primary breast and ovarian carcinomas.
Futreal, P., Liu, Q., Shattuck-Eidens, D., Cochran, C., Harshman, K., Tavtigian, S., Bennett, L., Haugen-Strano, A., Swensen, J., & Miki, Y. (1994) · Science · doi:10.1126/science.7939630 · Cited by 1,378
Brca1 Controls Homology-Directed DNA Repair
Moynahan, M. E., Chiu, J. W., Koller, B. H., & Jasin, M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80202-6 · Cited by 1,245
Méndez, J., & Stillman, B. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.22.8602-8612.2000 · Cited by 925
Schultz, L. B., Chehab, N. H., Malikzay, A., & Halazonetis, T. D. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.7.1381 · Cited by 916
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80503-6 · Cited by 900
The BRCT Domain Is a Phospho-Protein Binding Domain
Yu, X., Chini, C. C. S., He, M., Mer, G., & Chen, J. (2003) · Science · doi:10.1126/science.1088753 · Cited by 862
The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds
Tavtigian, S. V., Simard, J., Rommens, J. M., Couch, F. J., Shattuck-Eidens, D. M., Neuhausen, S. L., Merajver, S. D., Thorlacius, S., Offit, K., Stoppa‐Lyonnet, D., et al. (1996) · Nature Genetics · doi:10.1038/ng0396-333 · Cited by 838
A superfamily of conserved domains in DNA damage‐ responsive cell cycle checkpoint proteins
Bork, P., Hofmann, K., Bucher, P., Neuwald, A. F., Altschul, S. F., & Koonin, E. V. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.1.9034168 · Cited by 746
RAP80 Targets BRCA1 to Specific Ubiquitin Structures at DNA Damage Sites
Sobhian, B., Shao, G., Lilli, D. R., Culhane, A. C., Moreau, L. A., Xia, B., Livingston, D. M., & Greenberg, R. A. (2007) · Science · doi:10.1126/science.1139516 · Cited by 697
RecQ helicases: caretakers of the genome
Hickson, I. D. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1012 · Cited by 680
Cantor, S. B., Bell, D. W., Ganesan, S., Kass, E. M., Drapkin, R., Grossman, S., Wahrer, D. C. R., Sgroi, D. C., Lane, W. S., Haber, D. A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00304-x · Cited by 674
Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response
Zhong, Q., Chen, C.-F., Li, S., Chen, Y., Wang, C.-C., Xiao, J., Chen, P.-L., Sharp, Z. D., & Lee, W.-H. (1999) · Science · doi:10.1126/science.285.5428.747 · Cited by 626
From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair
Callebaut, I., & Mornon, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(96)01312-9 · Cited by 524
Breast cancer genetics: What we know and what we need
Nathanson, K. L., Wooster, R., & Weber, B. L. (2001) · Nature Medicine · doi:10.1038/87876 · Cited by 474
The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J
Levitus, M., Waisfisz, Q., Godthelp, B. C., Vries, Y. D., Hussain, S., Wiegant, W. W., Elghalbzouri-Maghrani, E., Steltenpool, J., Rooimans, M. A., Pals, G., et al. (2005) · Nature Genetics · doi:10.1038/ng1625 · Cited by 432
Koonin, E. V., Altschul, S. F., & Bork, P. (1996) · Nature Genetics · doi:10.1038/ng0796-266 · Cited by 373
The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia
Levran, O., Attwooll, C., Henry, R. T., Milton, K. L., Neveling, K., Rio, P., Batish, S. D., Kalb, R., Velleuer, E., Barral, S., et al. (2005) · Nature Genetics · doi:10.1038/ng1624 · Cited by 370
Genetic Analysis of BRCA1 Function in a Defined Tumor Cell Line
Scully, R., Ganesan, S., Vlasakova, K., Chen, J., Socolovsky, M., & Livingston, D. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80238-5 · Cited by 359
Involvement of H2AX in the DNA Damage and Repair Response
Martin, O. A., Pilch, D. R., Redon, C. E., & Bonner, W. M. (2003) · Cancer Biology & Therapy · doi:10.4161/cbt.2.3.373 · Cited by 311
Aberrant Subcellular Localization of BRCA1 in Breast Cancer
Chen, Y., Chen, C., Riley, D. J., Allred, D. C., Chen, P., Hoff, D. D. V., Osborne, C. K., & Lee, W. (1995) · Science · doi:10.1126/science.270.5237.789 · Cited by 309
Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1.
Williams, R. S., Green, R., & Glover, J. N. M. (2001) · Nature Structural Biology · doi:10.1038/nsb1001-838 · Cited by 292
Dong, Y., Hakimi, M., Chen, X., Kumaraswamy, E., Cooch, N. S., Godwin, A. K., & Shiekhattar, R. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00424-6 · Cited by 279
Self-citationDisruption of dog-1 in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA
Cheung, I. K., Schertzer, M. J., Rose, A. M., & Lansdorp, P. M. (2002) · Nature Genetics · doi:10.1038/ng928 · Cited by 270
Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility proteinPreprint
Lomonosov, M., Anand, S., Sangrithi, M. N., Davies, R. C., & Venkitaraman, A. R. (2003) · Genes & Development · doi:10.1101/gad.279003 · Cited by 263
Weber, C. A., Salazar, E. P., Stewart, S. A., & Thompson, L. H. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08260.x · Cited by 262
Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains
Rodriguez, M., Yu, X., Chen, J., & Songyang, Z. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300407200 · Cited by 234
A retarded rate of DNA chain growth in Bloom's syndrome.
Hand, R., & German, J. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.2.758 · Cited by 211
Bridge, W. L., Vandenberg, C. J., Franklin, R., & Hiom, K. J. (2005) · Nature Genetics · doi:10.1038/ng1627 · Cited by 209
Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines
Poot, M., Hoehn, H., Rünger, T. M., & Martin, G. M. (1992) · Experimental Cell Research · doi:10.1016/0014-4827(92)90074-i · Cited by 209
BRCA1 is a cell cycle-regulated nuclear phosphoprotein
Ruffner, H., & Verma, I. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7138 · Cited by 197
Karmakar, P., Piotrowski, J., Brosh, R. M., Sommers, J. A., Lees‐Miller, S. P., Cheng, W.-H., Snowden, C. M., Ramsden, D. A., & Bohr, V. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111523200 · Cited by 157
Chl1p, a DNA Helicase-Like Protein in Budding Yeast, Functions in Sister-Chromatid Cohesion
Skibbens, R. V. (2004) · Genetics · doi:10.1534/genetics.166.1.33 · Cited by 154
Marmorstein, L. Y., Kinev, A. V., Chan, G. K. T., Bochar, D. A., Beniya, H., Epstein, J. A., Yen, T. J., & Shiekhattar, R. (2001) · Cell · doi:10.1016/s0092-8674(01)00209-4 · Cited by 147
Self-citationDetection of Protein Folding Defects Caused by BRCA1-BRCT Truncation and Missense Mutations
Williams, R. S., Chasman, D. I., Hau, D., Hui, B., Lau, A. Y., & Glover, J. N. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m310182200 · Cited by 138
Tumorigenesis in mice carrying a truncating Brca1 mutationPreprint
Ludwig, T. G., Fisher, P. E., Ganesan, S., & Efstratiadis, A. (2001) · Genes & Development · doi:10.1101/gad.879201 · Cited by 130
Epidemiology, prevention, and early detection of breast cancer
Daudt, A. W., Alberg, A. J., & Helzlsouer, K. J. (1996) · Current Opinion in Oncology · doi:10.1097/00001622-199611000-00003 · Cited by 116
An abnormal profile of DNA replication intermediates in Bloom's syndrome.
Lönn, U., Lönn, S., Nylén, U., Winblad, G., & GERMAN, J. L. (1990) · PubMed · Cited by 109
Cytoplasmic mislocalization of BRCA1 caused by cancer-associated mutations in the BRCT domain
Rodríguez, J. A., Au, W. W. Y., & Henderson, B. R. (2003) · Experimental Cell Research · doi:10.1016/j.yexcr.2003.09.027 · Cited by 96
Inhibition of Mcm4,6,7 Helicase Activity by Phosphorylation with Cyclin A/Cdk2
Ishimi, Y., Komamura‐Kohno, Y., You, Z., Omori, A., & Kitagawa, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909040199 · Cited by 92
Zgheib, O., Huyen, Y., DiTullio, R. A., Snyder, A. R., Venere, M., Stavridi, E. S., & Halazonetis, T. D. (2005) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2005.06.026 · Cited by 90
Epidemiology, prevention, and early detection of breast cancer
Alberg, A. J., Lam, A. P., & Helzlsouer, K. J. (1999) · Current Opinion in Oncology · doi:10.1097/00001622-199911000-00003 · Cited by 50
Nüesch, J. P. F., Dettwiler, S., Corbau, R., & Rommelaere, J. (1998) · Journal of Virology · doi:10.1128/jvi.72.12.9966-9977.1998 · Cited by 39
Breast cancer and Fanconi anemia: what are the connections?
Zdzienicka, M. Z., & Arwert, F. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)02411-5 · Cited by 12
SUVi and BACH1: a new subfamily of mammalian helicases?
Menichini, P., & Michal Linial, B. (2001) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(01)00104-5 · Cited by 9
Flagged first, then by citations
Research works printed but not linked: 1
- Lonn U., 1990, Cancer Res, 50, 3141
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Moynahan, M. E., & Jasin, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2851 · Cited by 959
How the Fanconi Anemia Pathway Guards the Genome
Moldovan, G., & D’Andrea, A. D. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134222 · Cited by 601
PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response
Zhang, F., Ma, J., Wu, J., Ye, L., Cai, H., Xia, B., & Yu, X. (2009) · Current Biology · doi:10.1016/j.cub.2009.02.018 · Cited by 575
BRCA1 and its toolbox for the maintenance of genome integrity
Huen, M. S. Y., Sy, S. M.-H., & Chen, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2831 · Cited by 517
Wu, Y., Shin-ya, K., & Brosh, R. M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02210-07 · Cited by 428
Metadata
- Authors
- Kumaraswamy, E., & Shiekhattar, R.
- Affiliations
- The Wistar Institute (US)
- ORCID
- Shiekhattar, Ramin
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2007-10-01
- Volume
- 27
- Issue
- 19
- Pages
- 6733-6741
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC2099226
- OpenAlex
- W2138707085
- Cited by
- 110
- References
- 45
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 8 · 2014: 8 · 2013: 6 · 2012: 10
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (CA90758, R01CA090758)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- BACH1, BRCA1, BRCA2, DNA helicase, S phase progression, cell cycle, BRCT domain, DNA damage checkpoint, genomic instability, dephosphorylation, G1 phase, Caenorhabditis elegans, dominant negative mutation
- MeSH terms
- Animals, Chromatin, DNA Damage, Enzyme Activation, Humans, S Phase, Caenorhabditis elegans, BRCA1 Protein, BRCA2 Protein, Tumor Suppressor Proteins, RNA, Small Interfering, Ubiquitin-Protein Ligases, Multiprotein Complexes, Basic-Leucine Zipper Transcription Factors, Fanconi Anemia Complementation Group Proteins
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