Cited by 111DNA Repair MechanismsBRCA gene mutations in cancerCancer-related Molecular Pathways

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Activation of BRCA1/BRCA2-Associated Helicase BACH1 Is Required for Timely Progression through S Phase

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Kumaraswamy, Easwari, Shiekhattar, Ramin·2007·Molecular and Cellular Biology

DOI 10.1128/mcb.00961-07PMC PMC2099226

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Abstract

BACH1 (also known as FANCJ and BRIP1) is a DNA helicase that directly interacts with the C-terminal BRCT repeat of the breast cancer susceptibility protein BRCA1. Previous biochemical and functional analyses have suggested a role for the BACH1 homolog in Caenorhabditis elegans during DNA replication. Here, we report the association of BACH1 with a distinct BRCA1/BRCA2-containing complex during the S phase of the cell cycle. Depletion of BACH1 or BRCA1 using small interfering RNAs results in delayed entry into the S phase of the cell cycle. Such timely progression through S phase requires the helicase activity of BACH1. Importantly, cells expressing a dominant negative mutation in BACH1 that results in a defective helicase displayed increased activation of DNA damage checkpoints and genomic instability. BACH1 helicase is silenced during the G(1) phase of the cell cycle and is activated through a dephosphorylation event as cells enter S phase. These results point to a critical role for BACH1 helicase activity not only in the timely progression through the S phase but also in maintaining genomic stability.

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BRCA1 mutations in primary breast and ovarian carcinomas.
Futreal, P., Liu, Q., Shattuck-Eidens, D., Cochran, C., Harshman, K., Tavtigian, S., Bennett, L., Haugen-Strano, A., Swensen, J., & Miki, Y. (1994) · Science · doi:10.1126/science.7939630 · Cited by 1,378
Brca1 Controls Homology-Directed DNA Repair
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Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80503-6 · Cited by 900
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Yu, X., Chini, C. C. S., He, M., Mer, G., & Chen, J. (2003) · Science · doi:10.1126/science.1088753 · Cited by 862
The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds
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A superfamily of conserved domains in DNA damage‐ responsive cell cycle checkpoint proteins
Bork, P., Hofmann, K., Bucher, P., Neuwald, A. F., Altschul, S. F., & Koonin, E. V. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.1.9034168 · Cited by 746
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Nelson, N. C. (2015) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/2336

Authors: Kumaraswamy, E., & Shiekhattar, R.
Affiliations: The Wistar Institute (US)
ORCID: Shiekhattar, Ramin
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 2007-10-01
Volume: 27
Issue: 19
Pages: 6733-6741
ISSN: 0270-7306 (ISSN-L)
1098-5549
DOI: 10.1128/mcb.00961-07
PMC: PMC2099226
OpenAlex: W2138707085
Cited by: 110
References: 45
Citations by year: 2026: 1 · 2025: 2 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 8 · 2014: 8 · 2013: 6 · 2012: 10
FWCI: 5.43
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Molecular and Cellular Biology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Cancer Institute (CA90758, R01CA090758)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: BACH1, BRCA1, BRCA2, DNA helicase, S phase progression, cell cycle, BRCT domain, DNA damage checkpoint, genomic instability, dephosphorylation, G1 phase, Caenorhabditis elegans, dominant negative mutation
MeSH terms: Animals, Chromatin, DNA Damage, Enzyme Activation, Humans, S Phase, Caenorhabditis elegans, BRCA1 Protein, BRCA2 Protein, Tumor Suppressor Proteins, RNA, Small Interfering, Ubiquitin-Protein Ligases, Multiprotein Complexes, Basic-Leucine Zipper Transcription Factors, Fanconi Anemia Complementation Group Proteins

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Activation of BRCA1/BRCA2-Associated Helicase BACH1 Is Required for Timely Progression through S Phase

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