The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Positive Regulation of Interferon Regulatory Factor 3 Activation by Herc5 via ISG15 Modification
Open accessAbstract
Virus infection induces host antiviral responses, including induction of type I interferons. Transcription factor interferon regulatory factor 3 (IRF3) plays a pivotal role and is tightly regulated in this process. Here, we identify HERC5 (HECT domain and RLD 5) as a specific binding protein of IRF3 by immunoprecipitation. Ectopic expression or knockdown of HERC5 could, respectively, enhance or impair IRF3-mediated gene expression. Mechanistically, HERC5 catalyzes the conjugation of ubiquitin-like protein ISG15 onto IRF3 (Lys193, -360, and -366), thus attenuating the interaction between Pin1 and IRF3, resulting in sustained IRF3 activation. In contrast to results for wild-type IRF3, the mutant IRF3(K193,360,366R) interacts tightly with Pin1, is highly polyubiquitinated, and becomes less stable upon Sendai virus (SeV) infection. Consistently, host antiviral responses are obviously boosted or crippled in the presence or absence of HERC5, respectively. Collectively, this study characterizes HERC5 as a positive regulator of innate antiviral responses. It sustains IRF3 activation via a novel posttranslational modification, ISGylation.
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Cited by
Interferon-stimulated genes: A complex web of host defenses
Schneider, W. M., Chevillotte, M. D., & Rice, C. M. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120231 · Cited by 3,067
ISG15 in antiviral immunity and beyond
Perng, Y.-C., & Lenschow, D. J. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0020-5 · Cited by 855
Regulating IRFs in IFN Driven Disease
Jefferies, C. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00325 · Cited by 365
Moustaqil, M., Ollivier, E., Chiu, H.-P., Van Tol, S., Rudolffi-Soto, P., Stevens, C., Bhumkar, A., Hunter, D. J. B., Freiberg, A. N., Jacques, D., et al. (2021) · Emerging Microbes & Infections · doi:10.1080/22221751.2020.1870414 · Cited by 283
Negative regulation of type I IFN signaling
Arimoto, K.-I., Miyauchi, S., Stoner, S. A., Fan, J.-B., & Zhang, D.-E. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.2mir0817-342r · Cited by 117
Metadata
- Authors
- Shi, H.-X., Yang, K., Liu, X., Liu, X.-Y., Wei, B., Shan, Y.-F., Zhu, L.-H., & Wang, C.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2010-05-01
- Volume
- 30
- Issue
- 10
- Pages
- 2424-2436
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2163594990
- Cited by
- 266
- References
- 56
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- green
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- Shi, H.-X., Yang, K., Liu, X., Liu, X.-Y., Wei, B., Shan, Y.-F., Zhu, L.-H., & Wang, C. (2010). Positive Regulation of Interferon Regulatory Factor 3 Activation by Herc5 via ISG15 Modification. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.01466-09
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