The DOI matches its Crossref record; 192 of the 192 references it cites were found in a registry or an index.
Regulating IRFs in IFN Driven Disease
Open accessAbstract
The Interferon regulatory factors (IRFs) are a family of transcription factors that play pivotal roles in many aspects of the immune response, including immune cell development and differentiation and regulating responses to pathogens. Three family members, IRF3, IRF5, and IRF7, are critical to production of type I interferons downstream of pathogen recognition receptors that detect viral RNA and DNA. A fourth family member, IRF9, regulates interferon-driven gene expression. In addition, IRF4, IRF8, and IRF5 regulate myeloid cell development and phenotype, thus playing important roles in regulating inflammatory responses. Thus, understanding how their levels and activity is regulated is of critical importance given that perturbations in either can result in dysregulated immune responses and potential autoimmune disease. This review will focus the role of IRF family members in regulating type I IFN production and responses and myeloid cell development or differentiation, with particular emphasis on how regulation of their levels and activity by ubiquitination and microRNAs may impact autoimmune disease.
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Cites
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InfluentialRegulation of microRNA biogenesis
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Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
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IKKε and TBK1 are essential components of the IRF3 signaling pathway
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Cited by
The Multiple Roles of Interferon Regulatory Factor family in Health and Disease
Wang, L., Zhu, Y., Zhang, N., Xian, Y., Tang, Y., Ye, J., Reza, F., He, G., Wen, X., & Jiang, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01980-4 · Cited by 178
Research progress on interferon and cellular senescence
Wang, D., Chen, K., Wang, Z., Wu, H., & Li, Y. (2024) · The FASEB Journal · doi:10.1096/fj.202400808rr · Cited by 23
Chen, J., He, X., & Jakovlić, I. (2022) · BMC Ecology and Evolution · doi:10.1186/s12862-022-02088-5 · Cited by 5
Metadata
- Authors
- Jefferies, C. A.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2019-03-29
- Volume
- 10
- Pages
- 325-325
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2931761017
- Cited by
- 365
- References
- 192
- FWCI
- 13.54
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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