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Stress-Dependent Dynamics of Global Chromatin Remodeling in Yeast: Dual Role for SWI/SNF in the Heat Shock Stress Response
Open accessAbstract
Although chromatin structure is known to affect transcriptional activity, it is not clear how broadly patterns of changes in histone modifications and nucleosome occupancy affect the dynamic regulation of transcription in response to perturbations. The identity and role of chromatin remodelers that mediate some of these changes are also unclear. Here, we performed temporal genome-wide analyses of gene expression, nucleosome occupancy, and histone H4 acetylation during the response of yeast (Saccharomyces cerevisiae) to different stresses and report several findings. First, a large class of predominantly ribosomal protein genes, whose transcription was repressed during both heat shock and stationary phase, showed strikingly contrasting histone acetylation patterns. Second, the SWI/SNF complex was required for normal activation as well as repression of genes during heat shock, and loss of SWI/SNF delayed chromatin remodeling at the promoters of activated genes. Third, Snf2 was recruited to ribosomal protein genes and Hsf1 target genes, and its occupancy of this large set of genes was altered during heat shock. Our results suggest a broad and direct dual role for SWI/SNF in chromatin remodeling, during heat shock activation as well as repression, at promoters and coding regions.
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“SWI/SNF modulates nucleosome position to regulate the expression of a subset of genes including stress-responsive genes20,37–40.”
From SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes (2022) · cites this paper as [38]
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Metadata
- Authors
- Shivaswamy, S., & Iyer, V. R.
- Affiliations
- The University of Texas at Austin (US)
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2008-04
- Volume
- 28
- Issue
- 7
- Pages
- 2221-2234
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC2268435
- OpenAlex
- W2168333121
- Cited by
- 139
- References
- 61
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 2 · 2023: 4 · 2022: 7 · 2021: 9 · 2020: 8 · 2019: 10 · 2018: 9 · 2017: 10 · 2016: 7 · 2015: 6 · 2014: 6 · 2013: 7 · 2012: 9
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (R01CA095548, CA095548)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- chromatin remodeling, SWI/SNF complex, SnF2, heat shock response, histone H4 acetylation, nucleosome occupancy, transcriptional repression, ribosomal protein genes, stationary phase, Saccharomyces cerevisiae, stress response
- MeSH terms
- Adenosine Triphosphatases, DNA-Binding Proteins, Hot Temperature, Heat-Shock Proteins, Histones, Models, Genetic, Nucleosomes, Promoter Regions, Genetic, Saccharomyces cerevisiae, Transcription Factors, Transcription, Genetic, Gene Expression Regulation, Fungal, Oligonucleotide Array Sequence Analysis, Saccharomyces cerevisiae Proteins, Chromatin Assembly and Disassembly, Chromatin Immunoprecipitation
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