The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
RPD1 (SIN3/UME4) is required for maximal activation and repression of diverse yeast genes.
Open accessAbstract
We show that the extent of transcriptional regulation of many, apparently unrelated, genes in Saccharomyces cerevisiae is dependent on RPD1 (and RPD3 [M. Vidal and R. F. Gaber, Mol. Cell. Biol. 11:6317-6327, 1991]). Genes regulated by stimuli as diverse as external signals (PHO5), cell differentiation processes (SPO11 and SPO13), cell type (RME1, FUS1, HO, TY2, STE6, STE3, and BAR1), and genes whose regulatory signals remain unknown (TRK2) depend on RPD1 to achieve maximal states of transcriptional regulation. RPD1 enhances both positive and negative regulation of these genes: in rpd1 delta mutants, higher levels of expression are observed under repression conditions and lower levels are observed under activation conditions. We show that several independent genetic screens, designed to identify yeast transcriptional regulators, have detected the RPD1 locus (also known as SIN3, SD11, and UME4). The inferred RPD1 protein contains four regions predicted to take on helix-loop-helix-like secondary structures and three regions (acidic, glutamine rich, and proline rich) reminiscent of the activating domains of transcriptional activators.
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Cites
Yang-Yen, H.-F., Chambard, J.-C., Sun, Y.-L., Smeal, T., Schmidt, T. J., Drouin, J., & Karin, M. (1990) · Cell · doi:10.1016/0092-8674(90)90396-v · Cited by 1,553
A regulatory hierarchy for cell specialization in yeast
Herskowitz, I. (1989) · Nature · doi:10.1038/342749a0 · Cited by 590
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Grandori, C., Cowley, S. M., James, L. P., & Eisenman, R. N. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.653 · Cited by 1,333
Gao, L., Cueto, M. A., Asselbergs, F., & Atadja, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111871200 · Cited by 744
Histone Deacetylases and SAP18, a Novel Polypeptide, Are Components of a Human Sin3 Complex
Zhang, Y., Iratni, R., Erdjument-Bromage, H., Tempst, P., & Reinberg, D. (1997) · Cell · doi:10.1016/s0092-8674(00)80216-0 · Cited by 578
Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3
Rundlett, S. E., Carmen, A. A., Suka, N., Turner, B. M., & Grunstein, M. (1998) · Nature · doi:10.1038/33952 · Cited by 411
Metadata
- Authors
- Vidal, M., Strich, R., Esposito, R. E., & Gaber, R. F.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1991-12
- Volume
- 11
- Issue
- 12
- Pages
- 6306-6316
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2109192389
- Cited by
- 167
- References
- 2
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Vidal, M., Strich, R., Esposito, R. E., & Gaber, R. F. (1991). RPD1 (SIN3/UME4) is required for maximal activation and repression of diverse yeast genes. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.11.12.6306
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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