The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.
Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1.
Open accessAbstract
We have cloned a human cDNA from a new gene, spi-B, on the basis of its homology with the DNA-binding domain of the Spi-1/PU.1 putative oncogene product. spi-B codes for a protein of 262 amino acids presenting 43% overall identity with Spi-1. Its highly basic carboxy-terminal region exhibits 34% sequence identity with the DNA-binding domain of the Ets-1 protein. We showed that the Spi-B protein is able to bind the purine-rich sequence (PU box) recognized by Spi-1/PU.1 and to activate transcription of a reporter plasmid containing PU boxes. Chromosome in situ hybridization allowed us to map spi-B to the 19q13.3-19q13.4 region of the human genome. spi-B, like spi-1, was found to be expressed in various murine and human hematopoietic cell lines except T lymphoid cell lines.
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“whereas it is not expressed in mature T cells [22].”
From PU.1 and partners: regulation of haematopoietic stem cell fate in normal and malignant haematopoiesis (2009) · cites this paper as [22]
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IRF Family of Transcription Factors as Regulators of Host Defense
Taniguchi, T., Ogasawara, K., Takaoka, A., & Tanaka, N. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.623 · Cited by 1,658
Transcription Factors, Normal Myeloid Development, and Leukemia
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Molecular biology of the Ets family of transcription factors
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Rekhtman, N., Radparvar, F., Evans, T., & Skoultchi, A. I. (1999) · Genes & Development · doi:10.1101/gad.13.11.1398 · Cited by 454
“1 in the Ets domain; the two proteins are much less similar in other regions (Ray et al. 1992).”
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Metadata
- Authors
- Ray, D., Bosselut, R., Ghysdael, J., Mattei, M. G., Tavitian, A., & Moreau-Gachelin, F.
- Affiliations
- Inserm (FR)
- ORCID
- Bosselut, R
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1992-10
- Volume
- 12
- Issue
- 10
- Pages
- 4297-4304
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC360353
- OpenAlex
- W2097860375
- Cited by
- 157
- References
- 53
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 3 · 2021: 1 · 2020: 3 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 7
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Molecular and Cellular Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Association pour la Recherche sur le Cancer
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- Spi-B, transcription factors, ETS family, DNA-binding domain, transcriptional activation, cDNA cloning, gene mapping, hematopoietic cell lines
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Burkitt Lymphoma, Cell Line, Chromosome Mapping, Chromosomes, Human, Pair 19, Cloning, Molecular, DNA, DNA-Binding Proteins, Gene Expression Regulation, Humans, Molecular Sequence Data, Protein Binding, Transcription Factors, Transcription, Genetic, Tumor Cells, Cultured, Blotting, Northern, Retroviridae Proteins, Oncogenic, Sequence Homology, Mice
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