Cited by 157Genomics and Chromatin DynamicsRetinoids in leukemia and cellular processesHematopoietic Stem Cell Transplantation

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Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1.

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Ray, D, Bosselut, R, Ghysdael, J, Mattei, M G, Tavitian, A, Moreau-Gachelin, F·1992·Molecular and Cellular Biology

DOI 10.1128/mcb.12.10.4297PMC PMC360353

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Abstract

We have cloned a human cDNA from a new gene, spi-B, on the basis of its homology with the DNA-binding domain of the Spi-1/PU.1 putative oncogene product. spi-B codes for a protein of 262 amino acids presenting 43% overall identity with Spi-1. Its highly basic carboxy-terminal region exhibits 34% sequence identity with the DNA-binding domain of the Ets-1 protein. We showed that the Spi-B protein is able to bind the purine-rich sequence (PU box) recognized by Spi-1/PU.1 and to activate transcription of a reporter plasmid containing PU boxes. Chromosome in situ hybridization allowed us to map spi-B to the 19q13.3-19q13.4 region of the human genome. spi-B, like spi-1, was found to be expressed in various murine and human hematopoietic cell lines except T lymphoid cell lines.

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Authors: Ray, D., Bosselut, R., Ghysdael, J., Mattei, M. G., Tavitian, A., & Moreau-Gachelin, F.
Affiliations: Inserm (FR)
ORCID: Bosselut, R
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 1992-10
Volume: 12
Issue: 10
Pages: 4297-4304
ISSN: 0270-7306 (ISSN-L)
1098-5549
DOI: 10.1128/mcb.12.10.4297
PMC: PMC360353
OpenAlex: W2097860375
Cited by: 157
References: 53
Citations by year: 2025: 1 · 2024: 1 · 2022: 3 · 2021: 1 · 2020: 3 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 7
FWCI: 3.44
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Molecular and Cellular Biology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Association pour la Recherche sur le Cancer
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Keywords: Spi-B, transcription factors, ETS family, DNA-binding domain, transcriptional activation, cDNA cloning, gene mapping, hematopoietic cell lines
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Burkitt Lymphoma, Cell Line, Chromosome Mapping, Chromosomes, Human, Pair 19, Cloning, Molecular, DNA, DNA-Binding Proteins, Gene Expression Regulation, Humans, Molecular Sequence Data, Protein Binding, Transcription Factors, Transcription, Genetic, Tumor Cells, Cultured, Blotting, Northern, Retroviridae Proteins, Oncogenic, Sequence Homology, Mice

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Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1.

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