The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth.

A new technique for the assay of infectivity of human adenovirus 5 DNA

Graham, F. L., & van der Eb, A. J. (1973) · Virology · doi:10.1016/0042-6822(73)90341-3 · Cited by 9,302

p53 Mutations in Human Cancers

Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

Scheffner, M., Werness, B. A., Huibregtse, J. M., Levine, A. J., & Howley, P. M. (1990) · Cell · doi:10.1016/0092-8674(90)90409-8 · Cited by 3,995

The p53 tumour suppressor gene

Levine, A. J., Momand, J. A., & Finlay, C. A. (1991) · Nature · doi:10.1038/351453a0 · Cited by 3,785

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Momand, J., Zambetti, G. P., Olson, D. C., George, D., & Levine, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90644-r · Cited by 3,113

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

Werness, B. A., Levine, A. J., & Howley, P. M. (1990) · Science · doi:10.1126/science.2157286 · Cited by 2,562

T antigen is bound to a host protein in SY40-transformed cells

Lane, D. P., & Crawford, L. V. (1979) · Nature · doi:10.1038/278261a0 · Cited by 2,456

The p53 proto-oncogene can act as a suppressor of transformation

Finlay, C. A., Hinds, P. W., & Levine, A. J. (1989) · Cell · doi:10.1016/0092-8674(89)90045-7 · Cited by 1,987

Amplification of a gene encoding a p53-associated protein in human sarcomas

Oliner, J. D., Kinzler, K. W., Meltzer, P. S., George, D. L., & Vogelstein, B. (1992) · Nature · doi:10.1038/358080a0 · Cited by 1,949

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

Linzer, D. I. H., & Levine, A. J. (1979) · Cell · doi:10.1016/0092-8674(79)90293-9 · Cited by 1,814

Activating Mutations for Transformation by p53 Produce a Gene Product That Forms an hsc70-p53 Complex with an Altered Half-Life

Finlay, C. A., Hinds, P. W., Tan, T., Eliyahu, D., Oren, M., & Levine, A. J. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.2.531 · Cited by 1,144

Monoclonal antibodies specific for simian virus 40 tumor antigens

Harlow, E., Crawford, L. V., Pim, D. C., & Williamson, N. M. (1981) · Journal of Virology · doi:10.1128/jvi.39.3.861-869.1981 · Cited by 1,038

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

Gannon, J., Greaves, R. F., Iggo, R. D., & Lane, D. P. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08279.x · Cited by 970

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

Sarnow, P., Ho, Y.-S., Williams, J., & Levine, A. J. (1982) · Cell · doi:10.1016/0092-8674(82)90356-7 · Cited by 836

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

Fakharzadeh, S. S., Trusko, S. P., & George, D. L. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07676.x · Cited by 704

Wild-type p53 can inhibit oncogene-mediated focus formation.

Eliyahu, D., Michalovitz, D., Eliyahu, S., Pinhasi-Kimhi, O., & Oren, M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.8763 · Cited by 687

Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines.

Bártek, J., Iggo, R. D., Gannon, J., & Lane, D. P. (1990) · PubMed · Cited by 603

Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

Hinds, P. W., Finlay, C. A., & Levine, A. J. (1989) · Journal of Virology · doi:10.1128/jvi.63.2.739-746.1989 · Cited by 595

Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53

Jenkins, J. R., Rudge, K., & Currie, G. A. (1984) · Nature · doi:10.1038/312651a0 · Cited by 543

Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation

Crook, T., Vousden, K. H., & TIDY, J. A. (1991) · Cell · doi:10.1016/0092-8674(91)90529-8 · Cited by 503

Post-translational regulation of the 54K cellular tumor antigen in normal and transformed cells.

Oren, M., Maltzman, W., & Levine, A. J. (1981) · Molecular and Cellular Biology · doi:10.1128/mcb.1.2.101 · Cited by 489

Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells

Goldfarb, M. P., Shimizu, K., Perucho, M., & Wigler, M. H. (1982) · Nature · doi:10.1038/296404a0 · Cited by 484

Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA

Houweling, A., van den Elsen, P. J., & van der Eb, A. J. (1980) · Virology · doi:10.1016/0042-6822(80)90054-9 · Cited by 417

Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.

Hinds, P. W., Finlay, C. A., Quartin, R. S., Baker, S. J., Fearon, E. R., Vogelstein, B., & Levine, A. J. (1990) · PubMed · Cited by 408

p53 Cellular Tumor Antigen: Analysis of mRNA Levels in Normal Adult Tissues, Embryos, and Tumors

Rogel, A., Popliker, M., Webb, C., & Oren, M. (1985) · Molecular and Cellular Biology · doi:10.1128/mcb.5.10.2851 · Cited by 378

Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53.

Reich, N. C., Oren, M., & Levine, A. J. (1983) · Molecular and Cellular Biology · doi:10.1128/mcb.3.12.2143 · Cited by 310

Activating Mutations for Transformation by p53 Produce a Gene Product That Forms an hsc70-p53 Complex with an Altered Half-Life

Finlay, C. A., Hinds, P. W., Tan, T., et al. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.2.531-539.1988 · Cited by 301

Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53‐mediated repression of transcription.

Lechner, M. S., Mack, D. H., Finicle, A. B., Crook, T., Vousden, K. H., & Laimins, L. A. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05375.x · Cited by 272

Behavior of myc and ras Oncogenes in Transformation of Rat Embryo Fibroblasts

Land, H., Chen, A. C., Morgenstern, J. P., Parada, L. F., & Weinberg, R. A. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.6.1917 · Cited by 268

Monoclonal antibody analysis of p53 expression in normal and transformed cells

Yewdell, J. W., Gannon, J., & Lane, D. P. (1986) · Journal of Virology · doi:10.1128/jvi.59.2.444-452.1986 · Cited by 261

Tumor Suppressor p53: Analysis of Wild-Type and Mutant p53 Complexes

Milner, J., Medcalf, E., & Cook, A. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.1.12 · Cited by 243

Different Tumor-Derived p53 Mutants Exhibit Distinct Biological Activities

Halevy, O., Michalovitz, D., & Oren, M. (1990) · Science · doi:10.1126/science.2218501 · Cited by 234

Meth A fibrosarcoma cells express two transforming mutant p53 species.

Eliyahu, D., Goldfinger, N., Pinhasi-Kimhi, O., Shaulsky, G., Skurnik, Y. D., Arai, N., Rotter, V., & Oren, M. (1988) · PubMed · Cited by 233

Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines.

Hinds, P. W., Finlay, C. A., Frey, A. B., & Levine, A. J. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.8.2863 · Cited by 232

Post-Translational Regulation of the 54K Cellular Tumor Antigen in Normal and Transformed Cells

Oren, M., Maltzman, W., & Levine, A. J. (1981) · Molecular and Cellular Biology · doi:10.1128/mcb.1.2.101-110.1981 · Cited by 181

Mutant p53 proteins bind hsp 72/73 cellular heat shock-related proteins in SV40-transformed monkey cells.

Hw, S., Chumakov, P. M., Wj, W., et al. (1987) · PubMed · Cited by 163

Immortalization of rat embryo fibroblasts by the cellular p53 oncogene.

Rovinski, B., & Benchimol, S. (1988) · PubMed · Cited by 156

p53 Cellular Tumor Antigen: Analysis of mRNA Levels in Normal Adult Tissues, Embryos, and Tumors

Rogel, A., Popliker, M., Webb, C., et al. (1985) · Molecular and Cellular Biology · doi:10.1128/mcb.5.10.2851-2855.1985 · Cited by 121

Regulation of the level of the oncoprotein p53 in non-transformed and transformed cells.

Reihsaus, E., Kohler, M., Kraiss, S., Oren, M., & Montenarh, M. (1990) · PubMed · Cited by 109

Two Distinct Mechanisms Regulate the Levels of a Cellular Tumor Antigen, p53

Reich, N. C., Oren, M., & Levine, A. J. (1983) · Molecular and Cellular Biology · doi:10.1128/mcb.3.12.2143-2150.1983 · Cited by 106

Cold Spring Harbor Laboratory

Schroth, S. T. (2015) · doi:10.4135/9781483345758.n147 · Cited by 106

The p53 tumor suppressor gene

Micelli, G., Donadeo, A., & Quaranta, M. (1992) · Cell Biophysics · doi:10.1007/bf02789475 · Cited by 88

Tumor Suppressor p53: Analysis of Wild-Type and Mutant p53 Complexes

Milner, J., Medcalf, E., & Cook, A. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.1.12-19.1991 · Cited by 71

Cosmid vectors for high efficiency DNA-mediated transformation and gene amplification in mam- malian cells: studies with the human growth hormone gene

Choo, K. H. A., Filby, G., Greco, S., et al. (1986) · Gene · doi:10.1016/0378-1119(86)90412-9 · Cited by 34

Simian virus 40 can overcome the antiproliferative effect of wild-type p53 in the absence of stable large T antigen-p53 binding

Michael, D., Yehiely, F., Gottlieb, E., et al. (1991) · Journal of Virology · doi:10.1128/jvi.65.8.4160-4168.1991 · Cited by 25

WAF1, a potential mediator of p53 tumor suppression

El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321

Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain

Kussie, P. H., Gorina, S., Marechal, V., Elenbaas, B., Moreau, J., Levine, A. J., & Pavletich, N. P. (1996) · Science · doi:10.1126/science.274.5289.948 · Cited by 2,206

The p53-mdm-2 autoregulatory feedback loop.

Wu, X., Bayle, J. H., Olson, D., & Levine, A. J. (1993) · Genes & Development · doi:10.1101/gad.7.7a.1126 · Cited by 1,801

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2’s inhibition of p53

Pomerantz, J., Schreiber-Agus, N., Liégeois, N. J., Silverman, A., Alland, L., Chin, L., Potes, J., Chen, K., Orlow, I., Lee, H.-W., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81400-2 · Cited by 1,521

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

de Oca Luna, R. M., Wagner, D. S., & Lozano, G. (1995) · Nature · doi:10.1038/378203a0 · Cited by 1,420

Calcium phosphate transfection mammalian cells v2Preprint

Feijs, K. L. H. (2021) · doi:10.17504/protocols.io.bthqnj5w · Cited by 2

[23] Transcriptional activation analysis of oncogene function

Hauser, C. A., Der, C. J., & Cox, A. D. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(94)38025-2 · Cited by 13

Transfection of pcDNAHKv1.3 into Human Embryonic Kidney Cells

Cai, H. (2007) · Chinese Journal of Rehabilitation

Package of recombinant adenovirus of SHP-2 and transfection to the cardiomyocytes

Li, H. (2010) · Harbin Yike Daxue xuebao

Statistical experimental designs to optimize the transient transfection of HEK 293T cells and determine a transfer criterion from adherent cells to larger-scale cell suspension cultures

Dekevic, G., Tasto, L., Czermak, P., & Salzig, D. (2022) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2022.01.004 · Cited by 21