The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Cloning of Murine Stat6 and Human Stat6, Stat Proteins That Are Tyrosine Phosphorylated in Responses to IL-4 and IL-3 but Are Not Required for Mitogenesis
Open accessAbstract
By searching a database of expressed sequences, we identified a member of the signal transducers and activators of transcription (Stat) family of proteins. Human and murine full-length cDNA clones were obtained and sequenced. The sequence of the human cDNA was identical to the recently published sequence for interleukin-4 (IL-4)-Stat (J. Hou, U. Schindler, W.J. Henzel, T.C. Ho, M. Brasseur, and S. L. McKnight, Science 265:1701-1706, 1994), while the murine Stat6 amino acid and nucleotide sequences were 83 and 84% identical to the human sequences, respectively. Using Stat6-specific antiserum, we demonstrated that Stat6 is rapidly tyrosine phosphorylated following stimulation of appropriate cell lines with IL-4 or IL-3 but is not detectably phosphorylated following stimulation with IL-2, IL-12, or erythropoietin. In contrast, IL-2, IL-3, and erythropoietin induce the tyrosine phosphorylation of Stat5 while IL-12 uniquely induces the tyrosine phosphorylation of Stat4. Inducible tyrosine phosphorylation of Stat6 requires the membrane-distal region of the IL-4 receptor alpha chain. This region of the receptor is not required for cell growth, demonstrating that Stat6 tyrosine phosphorylation does not contribute to mitogenesis.
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Cites
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Self-citationInterleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor
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Cited by
Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells
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Essential role of Stat6 in IL-4 signalling
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Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
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Self-citationInterleukin-12: A Cytokine at the Interface of Inflammation and Immunity
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Metadata
- Authors
- Quelle, F. W., Shimoda, K., Thierfelder, W., Fischer, C., Kim, A., Ruben, S. M., Cleveland, J. L., Pierce, J. H., Keegan, A. D., Nelms, K., Paul, W. E., & Ihle, J. N.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1995-06-01
- Volume
- 15
- Issue
- 6
- Pages
- 3336-3343
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W1882823390
- Cited by
- 330
- References
- 57
- FWCI
- 16.79
- Type
- journal article
- Language
- en
- Open access
- green
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- Quelle, F. W., Shimoda, K., Thierfelder, W., Fischer, C., Kim, A., Ruben, S. M., Cleveland, J. L., Pierce, J. H., Keegan, A. D., Nelms, K., Paul, W. E., & Ihle, J. N. (1995). Cloning of Murine Stat6 and Human Stat6, Stat Proteins That Are Tyrosine Phosphorylated in Responses to IL-4 and IL-3 but Are Not Required for Mitogenesis. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.15.6.3336
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