Mutational Analysis of Hsp90 Function: Interactions with a Steroid Receptor and a Protein Kinase

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Items 101–200 of 422

1. Heat shock protein 90 catalyzes activation of the prekallikrein-kininogen complex in the absence of factor XII
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2. Molecular chaperones function as steroid receptor nuclear mobility factors
   Cem Elbi, Dawn A. Walker, Guillermo G. Romero, William P. Sullivan, David O. Toft, Gordon L. Hager, Donald Benedict DeFranco · 2004 · Proceedings of the National Academy of Sciences
3. Requirement for Hsp90 and a CyP-40-type Cyclophilin in Negative Regulation of the Heat Shock Response
   Duina, Andrea A., Kalton, Helen M., Gaber, Richard F. · 1998 · Journal of Biological Chemistry
4. The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation
   Kaushik Bhattacharya, Lorenz Weidenauer, Tania Morán Luengo, Ellis C. Pieters, Pablo C. Echeverría, Lilia Bernasconi, Diana Wider, Yashar Sadian, Margreet B. Koopman, Matthieu Villemin et al. · 2020 · Nature Communications
5. Heat Shock Proteins: Endogenous Modulators of Apoptotic Cell Death
   Céline Mirjolet, Elise Schmitt, Mathilde Brunet, Loic Maingret, Arnaud Parcellier, Carmen Garrido · 2005 · Springer eBooks
6. Apoprotein B Degradation Is Promoted by the Molecular Chaperones hsp90 and hsp70
   Viktoria Gusarova, Avrom J. Caplan, Jeffrey L. Brodsky, Edward A A Fisher · 2001 · Journal of Biological Chemistry
7. Degradation of a Cytosolic Protein Requires Endoplasmic Reticulum-associated Degradation Machinery
   Meredith Boyle Metzger, Matthew J. Maurer, Beverley M. Rabbitts, Susan Michaelis · 2008 · Journal of Biological Chemistry
8. Cancer proteomics: From identification of novel markers to creation of artifical learning models for tumor classification
   Ayodele A. Alaiya, Bo Franzén, Gert Auer, Stig T. Linder · 2000 · Electrophoresis
9. Conformational Switching of the Molecular Chaperone Hsp90 via Regulated Phosphorylation
   Soroka, Joanna, Wandinger, Sebastian K., Mäusbacher, Nina, Schreiber, Thiemo, Richter, Klaus, Daub, Henrik, Buchner, Johannes · 2012 · Molecular Cell
10. Control of estrogen receptor ligand binding by Hsp90
    Albert Fliss, Sharon Benzeno, Jie Rao, Avrom J. Caplan · 2000 · The Journal of Steroid Biochemistry and Molecular Biology
11. Dynamic Tyrosine Phosphorylation Modulates Cycling of the HSP90-P50CDC37-AHA1 Chaperone Machine
    Wanping Xu, Mehdi Mollapour, Chrisostomos Prodromou, Suiquan Wang, Bradley T. Scroggins, Zach Palchick, Kristin E. Beebe, Marco H. Siderius, Min-Jung Lee, Anthony D. Couvillon et al. · 2012 · Molecular Cell
12. Spotlight on 17‐ AAG as an Hsp90 inhibitor for molecular targeted cancer treatment
    Sona Talaei, Hassan Mellatyar, Asadollah Asadi, Abolfazl Akbarzadeh, Roghayeh Sheervalilou, Nosratollah Zarghami · 2019 · Chemical Biology & Drug Design
13. The Middle Domain of Hsp90 Acts as a Discriminator between Different Types of Client Proteins
    Hawle, Patricija, Siepmann, Martin, Harst, Anja, Siderius, Marco, Reusch, H. Peter, Obermann, Wolfgang M. J. · 2006 · Molecular and Cellular Biology
14. Cavefish and the basis for eye loss
    Jaya Krishnan, Nicolas Rohner · 2016 · Philosophical Transactions of the Royal Society B Biological Sciences
15. Annexin I is a stress protein induced by heat, oxidative stress and a sulfhydryl‐reactive agent
    Hae Jin Rhee, Geum‐Yi Kim, Jae‐Wan Huh, Seung Wook Kim, Doe Sun Na · 2000 · European Journal of Biochemistry
16. Functional Specificity of Co-Chaperone Interactions with Hsp90 Client Proteins
    D. Riggs, M. Cox, Joyce Cheung-Flynn, V. Prapapanich, P. Carrigan, David F. Smith · 2004 · Critical reviews in biochemistry and molecular biology
17. Assessment of aryl hydrocarbon receptor complex interactions using pBEVY plasmids: expressionvectors with bi-directional promoters for use in Saccharomyces cerevisiae
    Charles A. Miller · 1998 · Nucleic Acids Research
18. Asymmetric Hsp90 N Domain SUMOylation Recruits Aha1 and ATP-Competitive Inhibitors
    Mehdi Mollapour, Dimitra Bourboulia, Kristin E. Beebe, Mark R. Woodford, Sigrun Polier, Anthony Hoang, Raju R. Chelluri, Yu Li, Ailan Guo, Min-Jung Lee et al. · 2014 · Molecular Cell
19. Heat shock protein 90 from Escherichia coli collaborates with the DnaK chaperone system in client protein remodeling
    Genest, Olivier, Hoskins, Joel R., Camberg, Jodi L., Doyle, Shannon M., Wickner, Sue · 2011 · Proceedings of the National Academy of Sciences
20. Uncovering a region of heat shock protein 90 important for client binding in E. coli and chaperone function in yeast
    Genest, Olivier, Reidy, Michael, Street, Timothy O., Hoskins, Joel R., Camberg, Jodi L., Agard, David A., Masison, Daniel C., Wickner, Sue · 2013 · Molecular Cell
21. Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53
    Hagn, Franz, Lagleder, Stephan, Retzlaff, Marco, Rohrberg, Julia, Demmer, Oliver, Richter, Klaus, Buchner, Johannes, Kessler, Horst · 2011 · Nature Structural & Molecular Biology
22. A Systematic Survey of an Intragenic Epistatic Landscape
    Claudia Bank, Ryan T. Hietpas, Jeffrey D. Jensen, Daniel N. A. Bolon · 2014 · Molecular Biology and Evolution
23. Thermal, Chemical and pH Induced Denaturation of a Multimeric β-Galactosidase Reveals Multiple Unfolding Pathways
    Devesh Kishore, Suman Kundu, Arvind M. Kayastha · 2012 · PLoS ONE
24. The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA‐dependent kinase PKR
    Olivier Donzé, Toufik Abbas‐Terki, Didier Picard · 2001 · The EMBO Journal
25. Lysine Deacetylases Hda1 and Rpd3 Regulate Hsp90 Function thereby Governing Fungal Drug Resistance
    Robbins, Nicole, Leach, Michelle D., Cowen, Leah E. · 2012 · Cell Reports
26. Genetic Analysis of Viable Hsp90 Alleles Reveals a Critical Role in Drosophila Spermatogenesis
    Lin Yue, Timothy L. Karr, Debra F. Nathan, Hewson Swift, Shaila Srinivasan, Susan Lee Lindquist · 1999 · Genetics
27. Hsp90 is a core centrosomal component and is required at different stages of the centrosome cycle in Drosophila and vertebrates
    Bodo M. H. Lange, Angela Bachi, Matthias Wilm, Cayetano González · 2000 · The EMBO Journal
28. Aha1 competes with Hop, p50 and p23 for binding to the molecular chaperone Hsp90 and contributes to kinase and hormone receptor activation.
    A. Harst, Hong-Ying Lin, W. Obermann · 2005 · Biochemical Journal
29. Glucocorticoid sensitivity in humans-interindividual differences and acute stress effects
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30. Functional and physical interaction between yeast Hsp90 and Hsp70
    Kravats, Andrea N., Hoskins, Joel R., Reidy, Michael, Johnson, Jill L., Doyle, Shannon M., Genest, Olivier, Masison, Daniel C., Wickner, Sue · 2018 · Proceedings of the National Academy of Sciences
31. Dimerization of Hsp90 Is Required for in Vivo Function
    Natalie Wayne, Daniel N. A. Bolon · 2007 · Journal of Biological Chemistry
32. Two eukaryote-specific regions of Hsp82 are dispensable for its viability and signal transduction functions in yeast
    Jean-François Louvion, Rainer Warth, Didier Picard · 1996 · Proceedings of the National Academy of Sciences
33. Folding or holding?—Hsp70 and Hsp90 chaperoning of misfolded proteins in neurodegenerative disease
    Benjamin S. Rutledge, Wing‐Yiu Choy, Martin L. Duennwald · 2022 · Journal of Biological Chemistry
34. Independent Regulation of Hsp70 and Hsp90 Chaperones by Hsp70/Hsp90-organizing Protein Sti1 (Hop1)
    Youtao Song, Daniel C. Masison · 2005 · Journal of Biological Chemistry
35. Hsp90 Is Required for Pheromone Signaling in Yeast
    Jean-François Louvion, Toufik Abbas‐Terki, Didier Picard · 1998 · Molecular Biology of the Cell
36. Cdc37: a protein kinase chaperone?
    Tony Hunter, Randy Y.C. Poon · 1997 · Trends in Cell Biology
37. NO/cGMP Signaling and HSP90 Activity Represses Metamorphosis in the Sea UrchinLytechinus pictus
    Cory D. Bishop, Bruce P. Brandhorst · 2001 · Biological Bulletin
38. ATP-binding Properties of Human Hsp90
    Thomas Scheibel, Sonja Neuhofen, Tina Weikl, Christian Mayr, Jochen Reinstein, Pia D. Vogel, Johannes Büchner · 1997 · Journal of Biological Chemistry
39. Intra- and Intermonomer Interactions Are Required to Synergistically Facilitate ATP Hydrolysis in Hsp90
    Christian N. Cunningham, K. Krukenberg, D. Agard · 2008 · Journal of Biological Chemistry
40. Heat shock genes and the heat shock response in zebrafish embryos
    Patrick H. Krone, Zsolt Lele, Jennifer Beth Sass · 1997 · Biochemistry and Cell Biology
41. Comprehensive fitness maps of Hsp90 show widespread environmental dependence
    Flynn, Julia M, Rossouw, Ammeret, Cote-Hammarlof, Pamela, Fragata, Inês, Mavor, David, Hollins, Carl, Bank, Claudia, Bolon, Daniel NA · 2020 · eLife
42. Heat shock proteins and aging in Drosophila melanogaster
    Geneviève Morrow, Robert M. Tanguay · 2003 · Seminars in Cell and Developmental Biology
43. Specific Arabidopsis HSP90.2 alleles recapitulate RAR1 cochaperone function in plant NB-LRR disease resistance protein regulation
    David A. Hubert, Yijian He, Brian C. McNulty, Pablo Tornero, Jeffery L. Dangl · 2009 · Proceedings of the National Academy of Sciences
44. Importance of cycle timing for the function of the molecular chaperone Hsp90
    Bettina K. Zierer, Martin Rübbelke, Franziska Tippel, Tobias Madl, Florian H. Schopf, Daniel Andreas Rutz, Klaus Richter, Michael Sattler, Johannes Büchner · 2016 · Nature Structural & Molecular Biology
45. Identification of SSF1, CNS1, and HCH1 as multicopy suppressors of a Saccharomyces cerevisiae Hsp90 loss-of-function mutation
    Debra F. Nathan, Melissa Harju Vos, Susan Lee Lindquist · 1999 · Proceedings of the National Academy of Sciences
46. Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90
    Sophie L. Mader, Abraham López, Jannis Lawatscheck, Qi Luo, Daniel Andreas Rutz, Ana P. Gámiz‐Hernández, Michael Sattler, Johannes Büchner, Ville R. I. Kaila · 2020 · Nature Communications
47. Systematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 Function
    Parul Mishra, Julia M. Flynn, Tyler N. Starr, Daniel N. A. Bolon · 2016 · Cell Reports
48. The Hsp90 Molecular Chaperone Modulates Multiple Telomerase Activities
    Oyetunji A. Toogun, Diane C. DeZwaan, Brian Freeman · 2007 · Molecular and Cellular Biology
49. Molecular Interaction Network of the Hsp90 Chaperone System
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50. Regulation of metamorphosis in ascidians involves NO/cGMP signaling and HSP90
    Cory D. Bishop, William R Bates, Bruce P. Brandhorst · 2001 · Journal of Experimental Zoology
51. Latent Effects of Hsp90 Mutants Revealed at Reduced Expression Levels
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52. Requirement of Hsp90 for centrosomal function reflects its regulation of Polo kinase stability
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53. Sgt1 Associates with Hsp90: an Initial Step of Assembly of the Core Kinetochore Complex
    Parmil K. Bansal, Rashid Abdulle, Katsumi Kitagawa · 2004 · Molecular and Cellular Biology
54. The molecular chaperone Hsp90 can negatively regulate the activity of a glucocorticosteroid-dependent promoter
    Kwang Il Kang, Xia Meng, Jocelyne Leclerc, Ilham Bouhouche, Ahmed Chadli, Françoise Cadepond, Étienne-Émile Baulieu, Maria Grazia CATELLI · 1999 · Proceedings of the National Academy of Sciences
55. Involvement of Heat Shock Protein 90 in the Degradation of Mutant Insulin Receptors by the Proteasome
    Takeshi Imamura, Tetsuro Haruta, Yasumitsu Takata, Isao Usui, Minoru Iwata, Hajime Ishihara, Manabu Ishiki, Osamu Ishibashi, Eiichi Ueno, Toshiyasu Sasaoka et al. · 1998 · Journal of Biological Chemistry
56. A trans-Activation Domain in Yeast Heat Shock Transcription Factor Is Essential for Cell Cycle Progression during Stress
    Kevin A. Morano, Nicholas Santoro, Keith A. Koch, Dennis J. Thiele · 1999 · Molecular and Cellular Biology
57. Overexpression of Yeast Hsp110 Homolog Sse1p Suppressesydj1-151Thermosensitivity and Restores Hsp90-dependent Activity
    Jennifer L. Goeckeler-Fried, Andi Stephens, Paul C. Lee, Avrom J. Caplan, Jeffrey L. Brodsky · 2002 · Molecular Biology of the Cell
58. A systematic protocol for the characterization of Hsp90 modulators
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59. Conformational processing of oncogenic v-Src kinase by the molecular chaperone Hsp90
    Edgar E. Boczek, Lasse G. Reefschläger, Marco Dehling, Tobias J. Struller, Elisabeth Häusler, Andreas Seidl, Ville R. I. Kaila, Johannes Büchner · 2015 · Proceedings of the National Academy of Sciences
60. Cns1 Is an Essential Protein Associated with the Hsp90 Chaperone Complex in Saccharomyces cerevisiae That Can Restore Cyclophilin 40-Dependent Functions in cpr7ΔCells
    J. Marsh, Helen M. Kalton, R. F. Gaber · 1998 · Molecular and Cellular Biology
61. Administration of Hsp70 in vivo inhibits motor and sensory neuron degeneration
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62. A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity
    Victor A. Lopez, Brenden C. Park, Dominika Nowak, Anju Sreelatha, Patrycja Zembek, Jessie Fernandez, Kelly A. Servage, Marcin Gradowski, Jacek Hennig, Diana R. Tomchick et al. · 2019 · Cell
63. Role of SGT1 in the regulation of plant R gene signalling
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64. Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1
    Daniel Elnatan, Miguel Betegon, Y.X. Liu, Theresa A. Ramelot, Michael A. Kennedy, David A. Agard · 2017 · eLife
65. NEMO Trimerizes through Its Coiled-coil C-terminal Domain
    Agou, Fabrice, Ye, Fei, Goffinont, Stéphane, Courtois, Gilles, Yamaoka, Shoji, Israël, Alain, Véron, Michel · 2002 · Journal of Biological Chemistry
66. Hsp90 structure and function studied by NMR spectroscopy
    Tatiana Didenko, Afonso M. S. Duarte, Gülsün Elif Karagöz, Stefan Rüdiger · 2011 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
67. Hsp90 Binds and Regulates the Ligand-Inducible α Subunit of Eukaryotic Translation Initiation Factor Kinase Gcn2
    Olivier Donzé, Didier Picard · 1999 · Molecular and Cellular Biology
68. A Human Nuclear-Localized Chaperone that Regulates Dimerization, DNA Binding, and Transcriptional Activity of bZIP Proteins
    Ching-Man A. Virbasius, Susanne Wagner, Michael R. Green · 1999 · Molecular Cell
69. Purification of Polyglutamine Aggregates and Identification of Elongation Factor-1α and Heat Shock Protein 84 as Aggregate-Interacting Proteins
    Kenichi Mitsui, Hiroshi Nakayama, Takumi Akagi, Munenori Nekooki, Kenji Ohtawa, Koji Takio, Tsutomu Hashikawa, Nobuyuki Nukina · 2002 · Journal of Neuroscience
70. Increased ubiquitin‐dependent degradation can replace the essential requirement for heat shock protein induction
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71. Hsp90 as an anti-cancer target
    Len Neckers, Edward G. Mimnaugh, Theodor W. Schulte · 1999 · Drug Resistance Updates
72. Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors
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73. Folding in vivo of a newly translated yeast cytosolic enzyme is mediated by the SSA class of cytosolic yeast Hsp70 proteins
    Suwon Kim, Brenda A. Schilke, Elizabeth Anne Craig, Arthur L. Horwich · 1998 · Proceedings of the National Academy of Sciences
74. Disruption of Zebrafish Somite Development by Pharmacologic Inhibition of Hsp90
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75. Tpo1‐mediated spermine and spermidine export controls cell cycle delay and times antioxidant protein expression during the oxidative stress response
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76. Intrinsic Inhibition of the Hsp90 ATPase Activity
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77. Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor
    Noddings, Chari M., Johnson, Jill L., Agard, David A. · 2023 · Nature Structural & Molecular Biology
78. HEAT SHOCK PROTEIN 90C Is a Bona Fide Hsp90 That Interacts with Plastidic HSP70B in Chlamydomonas reinhardtii
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79. 2,3,7,8-Tetrachlorodibenzo- p -dioxin (TCDD)-mediated membrane translocation of c-Src protein kinase in liver WB-F344 cells
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80. CDC37 is required for p60v-src activity in yeast.
    Barna Dey, James J. Lightbody, Frank Boschelli · 1996 · Molecular Biology of the Cell
81. Nucleotide-Dependent Interaction of Saccharomyces cerevisiae Hsp90 with the Cochaperone Proteins Sti1, Cpr6, and Sba1
    Jill L. Johnson, Agnieszka Hałas, Gary A. Flom · 2006 · Molecular and Cellular Biology
82. Specific localization of zebrafishhsp90α mRNA tomyoD-expressing cells suggests a role for hsp90α during normal muscle development
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83. A Conformational Switch in the Ligand-binding Domain Regulates the Dependence of the Glucocorticoid Receptor on Hsp90
    Derek Ricketson, Ute Hostick, L. Fang, Keith R. Yamamoto, Beatrice D. Darimont · 2007 · Journal of Molecular Biology
84. The Interaction between Sgt1p and Skp1p Is Regulated by HSP90 Chaperones and Is Required for Proper CBF3 Assembly
    Linda B. Lingelbach, Kenneth B. Kaplan · 2004 · Molecular and Cellular Biology
85. Heat shock protein gene expression during embryonic development of the zebrafish
    Patrick H. Krone, Jennifer Beth Sass, Zsolt Lele · 1997 · Cellular and Molecular Life Sciences
86. c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells
    Diana M. Dunn, Mark R. Woodford, Andrew W. Truman, Sandra Jensen, Jacqualyn J. Schulman, Tiffany N. Caza, Taylor C. Remillard, David R. Loiselle, Donald J. Wolfgeher, Brian S. J. Blagg et al. · 2015 · Cell Reports
87. HSP90/70 chaperones are required for rapid nucleosome removal upon induction of the GAL genes of yeast
    Monique Floer, Gene O. Bryant, Mark Ptashne · 2008 · Proceedings of the National Academy of Sciences
88. Hsp90 and Hsp40/Erdj3 are required for the expression and anti-apoptotic function of KSHV K1
    K W Wen, Blossom Damania · 2010 · Oncogene
89. Expressed in the Yeast Saccharomyces cerevisiae , Human ERK5 Is a Client of the Hsp90 Chaperone That Complements Loss of the Slt2p (Mpk1p) Cell Integrity Stress-Activated Protein Kinase
    Andrew W. Truman, Stefan H. Millson, James M. Nuttall, Victoria King, Mehdi Mollapour, Chrisostomos Prodromou, Laurence H. Pearl, Peter W. Piper · 2006 · Eukaryotic Cell
90. Dissection of the Contribution of Individual Domains to the ATPase Mechanism of Hsp90
    Harald Wegele, Paul Muschler, Melanie Bunck, Jochen Reinstein, Johannes Büchner · 2003 · Journal of Biological Chemistry
91. Hsp90 enables Ctf13p/Skp1p to nucleate the budding yeast kinetochore
    Olaf Stemmann, Anke Neidig, Thomas Köcher, Matthias S. Wilm, Johannes Lechner · 2002 · Proceedings of the National Academy of Sciences
92. Yeast Dam1p Is Required to Maintain Spindle Integrity during Mitosis and Interacts with the Mps1p Kinase
    Michele Haltiner Jones, Jeffrey B. Bachant, Andrea Castillo, Thomas H. Giddings, Mark Winey · 1999 · Molecular Biology of the Cell
93. Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity
    Mollapour, Mehdi, Tsutsumi, Shinji, Kim, Yeong Sang, Trepel, Jane, Neckers, Len · 2011 · Oncotarget
94. Downregulation of the Hsp90 System Causes Defects in Muscle Cells of Caenorhabditis Elegans
    Andreas M. Gaiser, Christoph J. O. Kaiser, Veronika Haslbeck, Klaus Richter · 2011 · PLoS ONE
95. Mutational analysis of Hsp90α dimerization and subcellular localization: dimer disruption does not impede ‘in vivo’ interaction with estrogen receptor
    Xia Meng, Jocelyne Devin, William P. Sullivan, David O. Toft, Étienne-Émile Baulieu, Maria Grazia CATELLI · 1996 · Journal of Cell Science
96. Sensitivity to Hsp90‐targeting drugs can arise with mutation to the Hsp90 chaperone, cochaperones and plasma membrane ATP binding cassette transporters of yeast
    Peter W. Piper, Stefan H. Millson, Mehdi Mollapour, Barry Panaretou, Giuliano Siligardi, Laurence H. Pearl, Chrisostomos Prodromou · 2003 · European Journal of Biochemistry
97. Inhibition of mineralocorticoid and glucocorticoid receptor function by the heat shock protein 90-binding agent geldanamycin1Supported by the Deutsche Forschungsgemeinschaft (DFG-Grant Ka 1039/2-1).1
    Christoph M. Bamberger, Martin Wald, Ana‐Maria Bamberger, Heinrich M. Schulte · 1997 · Molecular and Cellular Endocrinology
98. Structural elements in the flexible tail of the co-chaperone p23 coordinate client binding and progression of the Hsp90 chaperone cycle
    Biebl, Maximilian M., Lopez, Abraham, Rehn, Alexandra, Freiburger, Lee, Lawatscheck, Jannis, Blank, Birgit, Sattler, Michael, Buchner, Johannes · 2021 · Nature Communications
99. Folding and association of β-galactosidase
    Alfons Nichtl, Johannes Büchner, Rainer Jaenicke, Rainer Rudolph, Thomas Scheibel · 1998 · Journal of Molecular Biology
100. The Ydj1 molecular chaperone facilitates formation of active p60v-src in yeast.
     Barna Dey, A J Caplan, Frank Boschelli · 1996 · Molecular Biology of the Cell