Lindquist, Susan

HSP90 and the chaperoning of cancer

Whitesell, L., & Lindquist, S. L. (2005) · Nature Reviews Cancer

Heat shock proteins researchCancer-related Molecular Pathways

Cited by 2,502

Hsp90 as a capacitor for morphological evolution

Rutherford, S. L., & Lindquist, S. (1998) · Nature

Heat shock proteins researchEvolution and Genetic Dynamics

Cited by 2,270

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

Taipale, M., Jarosz, D. F., & Lindquist, S. (2010) · Nature Reviews Molecular Cell Biology

Heat shock proteins researchUbiquitin and proteasome pathways

Cited by 1,818

Hsp90 as a capacitor of phenotypic variation

Queitsch, C., Sangster, T. A., & Lindquist, S. (2002) · Nature

Heat shock proteins researchEvolution and Genetic Dynamics

Cited by 1,372

The FLP recombinase of yeast catalyzes site-specific recombination in the drosophila genome

Golic, K. G., & Lindquist, S. (1989) · Cell

CRISPR and Genetic EngineeringDNA Repair Mechanisms

Cited by 942

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

Taipale, M., Krykbaeva, I., Koeva, M., Kayatekin, C., Westover, K. D., Karras, G. I., & Lindquist, S. (2012) · Cell

Heat shock proteins researchUbiquitin and proteasome pathways

Cited by 879

Reduced levels of hsp90 compromise steroid receptor action in vivo

Picard, D., Khursheed, B., Garabedian, M. J., Fortin, M. G., Lindquist, S., & Yamamoto, K. R. (1990) · Nature

Heat shock proteins researchEstrogen and related hormone effects

Cited by 787

Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations

Soldner, F., Laganière, J., Cheng, A. W., Hockemeyer, D., Gao, Q., Alagappan, R., Khurana, V., Golbe, L. I., Myers, R. H., Lindquist, S., et al. (2011) · Cell

Pluripotent Stem Cells ResearchCRISPR and Genetic Engineering

Cited by 728

Hsp90 Potentiates the Rapid Evolution of New Traits: Drug Resistance in Diverse Fungi

Cowen, L. E., & Lindquist, S. (2005) · Science

Heat shock proteins researchEvolution and Genetic Dynamics

Cited by 698

Mitochondrial metabolism promotes adaptation to proteotoxic stress

Tsvetkov, P., Detappe, A., Cai, K., Keys, H. R., Brune, Z., Ying, W., Thiru, P., Reidy, M., Kugener, G., Rossen, J., et al. (2019) · Nature Chemical Biology

Ubiquitin and proteasome pathwaysCell death mechanisms and regulation

Cited by 645

Widespread macromolecular interaction perturbations in human genetic disorders

Sahni, N., Yi, S., Taipale, M., Fuxman Bass, J. I., Coulombe-Huntington, J., Yang, F., Peng, J., Weile, J., Karras, G. I., Wang, Y., et al. (2015) · Cell

Genomics and Rare DiseasesBioinformatics and Genomic Networks

Cited by 594

Prions as adaptive conduits of memory and inheritance

Shorter, J., & Lindquist, S. (2005) · Nature Reviews Genetics

Prion Diseases and Protein MisfoldingAlzheimer's disease research and treatments

Cited by 555

Mutational Analysis of Hsp90 Function: Interactions with a Steroid Receptor and a Protein Kinase

Nathan, D. F., & Lindquist, S. (1995) · Molecular and Cellular Biology

Heat shock proteins researchFungal and yeast genetics research

Cited by 423

Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or α-Synuclein

Willingham, S., Outeiro, T. F., DeVit, M. J., Lindquist, S. L., & Muchowski, P. J. (2003) · Science

Genetic Neurodegenerative DiseasesParkinson's Disease Mechanisms and Treatments

Cited by 422

Increase in Activity During Calorie Restriction Requires Sirt1

Chen, D., Steele, A. D., Lindquist, S., & Guarente, L. (2005) · Science

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 419

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease

Cowen, L. E., Singh, S. D., Köhler, J. R., Collins, C., Zaas, A. K., Schell, W. A., Aziz, H., Mylonakis, E., Perfect, J. R., Whitesell, L., et al. (2009) · Proceedings of the National Academy of Sciences

Antifungal resistance and susceptibilityHeat shock proteins research

Cited by 413

The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy

Scherz-Shouval, R., Santagata, S., Mendillo, M. L., Sholl, L. M., Ben-Aharon, I., Beck, A. H., Dias-Santagata, D., Koeva, M., Stemmer, S. M., Whitesell, L., et al. (2014) · Cell

Heat shock proteins researchTGF-β signaling in diseases

Cited by 386

Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer’s Disease Risk Factors in Yeast

Treusch, S., Hamamichi, S., Goodman, J. L., Matlack, K. E. S., Chung, C. Y., Baru, V., Shulman, J. M., Parrado, A., Bevis, B. J., Valastyan, J. S., et al. (2011) · Science

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 379

In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone

Nathan, D. F., Vos, M. H., & Lindquist, S. (1997) · Proceedings of the National Academy of Sciences

Heat shock proteins researchFungal and yeast genetics research

Cited by 364

Hsp90 and Environmental Stress Transform the Adaptive Value of Natural Genetic Variation

Jarosz, D. F., & Lindquist, S. (2010) · Science

Evolution and Genetic DynamicsHeat shock proteins research

Cited by 346

APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia

Sienski, G., Narayan, P., Bonner, J. M., Kory, N., Boland, S., Arczewska, A. A., Ralvenius, W. T., Akay, L., Lockshin, E., He, L., et al. (2021) · Science Translational Medicine

Alzheimer's disease research and treatmentsLipid metabolism and biosynthesis

Cited by 336

Fitness Trade-offs Restrict the Evolution of Resistance to Amphotericin B

Vincent, B. M., Lancaster, A. K., Scherz-Shouval, R., Whitesell, L., & Lindquist, S. (2013) · PLoS Biology

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 322

Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition

Lambert, J.-P., Ivosev, G., Couzens, A. L., Larsen, B., Taipale, M., Lin, Z.-Y., Zhong, Q., Lindquist, S., Vidal, M., Aebersold, R., et al. (2013) · Nature Methods

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 318

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

Fanning, S., Haque, A., Imberdis, T., Baru, V., Barrasa, M. I., Nuber, S., Termine, D., Ramalingam, N., Ho, G. P. H., Noble, T., et al. (2019) · Molecular Cell

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 285