Cited by 317TGF-β signaling in diseasesProtein Kinase Regulation and GTPase SignalingDevelopmental Biology and Gene Regulation

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Activation of Signalling by the Activin Receptor Complex

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Attisano, Liliana, Wrana, Jeffrey L., Montalvo, Ermelinda, Massagué, Joan·1996·Molecular and Cellular Biology

DOI 10.1128/mcb.16.3.1066PMC PMC231089

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Abstract

Activin exerts its effects by simultaneously binding to two types of p rotein serine/threonine kinase receptors, each type existing in various isoforms. Using the ActR-IB and ActR-IIB receptor isoforms, we have investigated the mechanism of activin receptor activation. ActR-IIB are phosphoproteins with demonstrable affinity for each other. However, activin addition strongly promotes an interaction between these two proteins. Activin binds directly to ActR-IIB, and this complex associates with ActR-IB, which does not bind ligand on its own. In the resulting complex, ActR-IB becomes hyperphosphorylated, and this requires the kinase activity of ActR-IIB. Mutation of conserved serines and threonines in the GS domain, a region just upstream of the kinase domain in ActR-IB, abrogates both phosphorylation and signal propagation, suggesting that this domain contains phosphorylation sites required for signalling. ActR-IB activation can be mimicked by mutation of Thr-206 to aspartic acid, which yields a construct, ActR-IB(T206D), that signals in the absence of ligand. Furthermore, the signalling activity of this mutant construct is undisturbed by overexpression of a dominant negative kinase-defective ActR-IIB construct, indicating that ActR-IB(T206D) can signal independently of ActR-IIB. The evidence suggests that ActR-IIB acts as a primary activin receptor and ActR-IB acts as a downstream transducer of activin signals.

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Authors: Attisano, L., Wrana, J. L., Montalvo, E., & Massagué, J.
Affiliations: Memorial Sloan Kettering Cancer Center (US)
ORCID: Attisano, Liliana
Wrana, Jeffrey L.
Massagué, Joan
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 1996-03-01
Volume: 16
Issue: 3
Pages: 1066-1073
ISSN: 0270-7306 (ISSN-L)
1098-5549
DOI: 10.1128/mcb.16.3.1066
PMC: PMC231089
OpenAlex: W2103042473
Cited by: 316
References: 62
Citations by year: 2026: 1 · 2025: 7 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 6 · 2019: 9 · 2018: 9 · 2017: 2 · 2016: 12 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 5
FWCI: 9.35
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Molecular and Cellular Biology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (CA34610)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: activin signalling, receptor activation, receptor phosphorylation, receptor kinase activity, signal transduction
MeSH terms: Amino Acid Sequence, Animals, Cell Line, Ligands, Molecular Sequence Data, Mutation, Transfection, Signal Transduction, Protein Serine-Threonine Kinases, Receptors, Growth Factor, Activin Receptors

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Activation of Signalling by the Activin Receptor Complex

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