The DOI matches its Crossref record; 83 of the 88 references it cites were found in a registry or an index, and 5 are not checked yet.
CCAAT Enhancer-Binding Protein (C/EBP) and AML1 (CBFα2) Synergistically Activate the Macrophage Colony-Stimulating Factor Receptor Promoter
Open accessAbstract
Transcription factors play a key role in the development and differentiation of specific lineages from multipotential progenitors. Identification of these regulators and determining the mechanism of how they activate their target genes are important for understanding normal development of monocytes and macrophages and the pathogenesis of a common form of adult acute leukemia, in which the differentiation of monocytic cells is blocked. Our previous work has shown that the monocyte-specific expression of the macrophage colony-stimulating factor (M-CSF) receptor is regulated by three transcription factors interacting with critical regions of the M-CSF receptor promoter, including PU.1 and AML1.PU.1 is essential for myeloid cell development, while the AML1 gene is involved in several common leukemia-related chromosome translocations, although its role in hematopoiesis has not been fully identified. Along with AML1, a third factor, Mono A, interacts with a small region of the promoter which can function as a monocyte-specific enhancer when multimerized and linked to a heterologous basal promoter. Here, we demonstrate by electrophoretic mobility shift assays with monocytic nuclear extracts, COS-7 cell-transfected factors, and specific antibodies that the monocyte-enriched factor Mono A is CCAAT enhancer-binding protein (C/EBP). C/EBP has been shown previously to be an important transcription factor involved in hepatocyte and adipocyte differentiation; in hematopoietic cells, C/EBP is specifically expressed in myeloid cells. In vitro binding analysis reveals a physical interaction between C/EBP and AML1. Further transfection studies show that C/EBP and AML1 in concert with the AML1 heterodimer partner CBF beta synergistically activate M-CSF receptor by more then 60 fold. These results demonstrate that C/EBP and AML1 are important factors for regulating a critical hematopoietic growth factor receptor, the M-CSF receptor, suggesting a mechanism of how the AML1 fusion protein could contribute to acute myeloid leukemia. Furthermore, they demonstrate physical and functional interactions between AML1 and C/EBP transcription factor family members.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Citations
Cites
Dignam, J. D., Lebovitz, R. M., & Roeder, R. G. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.5.1475 · Cited by 11,262
Smith, D. B., & Johnson, K. S. (1988) · Gene · doi:10.1016/0378-1119(88)90005-4 · Cited by 5,844
The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins
Landschulz, W. H., Johnson, P. F., & McKnight, S. L. (1988) · Science · doi:10.1126/science.3289117 · Cited by 3,443
Andrews, N. C., & Faller, D. V. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.9.2499 · Cited by 2,337
Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.
Cao, Z., Umek, R. M., & McKnight, S. L. (1991) · Genes & Development · doi:10.1101/gad.5.9.1538 · Cited by 1,663
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
Scott, E. W., Simon, M. C., Anastasi, J., & Singh, H. (1994) · Science · doi:10.1126/science.8079170 · Cited by 1,532
A nuclear factor for IL‐6 expression (NF‐IL6) is a member of a C/EBP family.
Akira, S., Isshiki, H., Sugita, T., Tanabe, O., Kinoshita, S. M., Nishio, Y., Nakajima, T., Hirano, T., & Kishimoto, T. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08316.x · Cited by 1,450
The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene
Klemsz, M. J., McKercher, S. R., Celada, A., Van Beveren, C., & Maki, R. A. (1990) · Cell · doi:10.1016/0092-8674(90)90219-5 · Cited by 954
Impaired Energy Homeostasis in C/EBPα Knockout Mice
Wang, N.-D., Finegold, M. J., Bradley, A., Ou, C. N., Abdelsayed, S. V., Wilde, M. D., Taylor, L. R., Wilson, D. R., & Darlington, G. J. (1995) · Science · doi:10.1126/science.7652557 · Cited by 929
Isolation of a recombinant copy of the gene encoding C/EBP.Preprint
Landschulz, W. H., Johnson, P. F., Adashi, E. Y., Graves, B. J., & McKnight, S. L. (1988) · Genes & Development · doi:10.1101/gad.2.7.786 · Cited by 927
Research works printed but not linked: 8
- Bae S. C., 1993, Oncogene, 8, 809
- Lenny N., 1995, Oncogene, 11, 1761
- Pahl H. L., 1991, Exp. Hematol., 19, 1038
- Tsukada J., 1994, Mol. Cell. Biol., 14, 7285
- Visvader J., 1989, Mol. Cell. Biol., 9, 1336
- Wang S., 1993, Mol. Cell. Biol., 13, 3324
- Zhang D. E., 1994, Mol. Cell. Biol., 14, 8085
- Zhang D.-E., 1994, Mol. Cell. Biol., 14, 373
Cited by
Sorted by citations
Items 301–398 of 398
Lian, J. B., & Stein, G. S. (2003) · Calcified Tissue International · doi:10.1007/s00223-002-1058-x · Cited by 16
Krauter, J., Heil, G., & Ganser, A. (2000) · Hematology · doi:10.1080/10245332.2000.11746532 · Cited by 16
Barat, C., & Rassart, É. (1998) · Journal of Virology · doi:10.1128/jvi.72.7.5579-5588.1998 · Cited by 16
Molecular Basis of Hematological Disease Caused by Inherited or Acquired RUNX1 Mutations
Kellaway, S. G., Coleman, D. J. L., Cockerill, P. N., Raghavan, M., & Bonifer, C. (2022) · Experimental Hematology · doi:10.1016/j.exphem.2022.03.009 · Cited by 15
Lu, L., Wen, Y., Yao, Y., Chen, F., Wang, G., Wu, F., Wu, J., Narayanan, P., Redell, M. S., Mo, Q., et al. (2018) · Theranostics · doi:10.7150/thno.22800 · Cited by 15
Senyuk, V. I., Li, D., Zakharov, A. D., Mikhail, F. M., & Nucifora, G. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0412 · Cited by 15
Kasthuri, S. R., Premachandra, H. K. A., Umasuthan, N., Whang, I., & Lee, J. (2013) · Gene · doi:10.1016/j.gene.2013.04.079 · Cited by 14
C/EBP-ε: Chromosomal mapping and mutational analysis of the gene in leukemia and preleukemia
Koike, M., Chumakov, A. M., Takeuchi, S., Tasaka, T., Yang, R., Nakamaki, T., Tsuruoka, N., & Koeffler, H. P. (1997) · Leukemia Research · doi:10.1016/s0145-2126(97)00072-6 · Cited by 14
Jacobs, P. T., Cao, L. H., Samon, J. B., Kane, C. A., Hedblom, E., Bowcock, A. M., & Telfer, J. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069083 · Cited by 13
Stein, G. S., Lian, J. B., Stein, J. L., van Wijnen, A. J., Montecino, M. A., Pratap, J., Choi, J., Zaidi, S. K., Javed, A., Gutierrez, S. E., et al. (2003) · Blood Cells Molecules and Diseases · doi:10.1016/s1079-9796(03)00029-9 · Cited by 13
Okazaki, K., Yu, H., Davies, S. R., Imamura, T., & Sandell, L. J. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20648 · Cited by 13
Proleukemic RUNX1 and CBFβ Mutations in the Pathogenesis of Acute Leukemia
Engel, M. E., & Hiebert, S. W. (2009) · Cancer treatment and research · doi:10.1007/978-0-387-69259-3_8 · Cited by 12
Self-citationMolecular Diagnosis in Pediatric Acute Leukemias
Bartolo, C., & Viswanatha, D. S. (2000) · Clinics in Laboratory Medicine · doi:10.1016/s0272-2712(18)30081-7 · Cited by 12
Clusterin Gene in Rat Sertoli Cells Is Regulated by a Core-Enhancer Element
Lymar, E. S., Clark, A. M., Reeves, R., & Griswold, M. D. (2000) · Biology of Reproduction · doi:10.1095/biolreprod63.5.1341 · Cited by 11
Yonezawa, T., Takahashi, H., Shikata, S., Sawasaki, T., Kitamura, T., & Goyama, S. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.10.006 · Cited by 10
P/CAF and GCN5 acetylate the AML1/MDS1/EVI1 fusion oncoprotein
Senyuk, V. I., Sinha, K. K., Chakraborty, S., Buonamici, S., & Nucifora, G. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01288-9 · Cited by 10
Stein, G. S., Stein, J. L., Lian, J. B., van Wijnen, A. J., Montecino, M. A., Javed, A., Zaidi, S. K., Young, D. W., Choi, J. Y., & Pockwinse, S. M. (2004) · PubMed · doi:10.4081/860 · Cited by 10
Transcriptional Activation of the Pirb Gene in B Cells by PU.1 and Runx3
Arita, K., Endo, S., Kaifu, T., Kitaguchi, K., Nakamura, A., Ohmori, H., Kohu, K., Satake, M., & Takai, T. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1001302 · Cited by 9
Wang, W., Meng, Y., Chen, Y., Yu, Y., Wang, H., Yang, S., & Sun, W. (2022) · Oncogene · doi:10.1038/s41388-022-02414-7 · Cited by 9
Smith, A. M., Park, T., Aalderink, M., Oldfield, R. L., Bergin, P., Mee, E. W., Faull, R. L. M., & Dragunow, M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1047928 · Cited by 9
A transcriptional landscape of 28 porcine tissues obtained by super deepSAGE sequencing
Huang, T., Yang, M., Dong, K., Xu, M., Liu, J., Chen, Z. J., Zhu, S., Chen, W., Yin, J., Jin, K., et al. (2020) · BMC Genomics · doi:10.1186/s12864-020-6628-7 · Cited by 9
Lineage specificity of CBFA2 fusion transcripts
Dann, E. J., Fears, S. C., Arád-Dann, H., Nucifora, G., & Rowley, J. D. (2000) · Leukemia Research · doi:10.1016/s0145-2126(99)00150-2 · Cited by 9
Control of histone modifications
Davie, J., & Spencer, V. A. (1999) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(1999)75:32+ · Cited by 146
Wang, Y., Li, Z., Chen, W., Wang, J., Huang, Z., Yu, X.-J., Zhang, Y., Zheng, L., & Xu, J. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216638 · Cited by 8
SERPINB13 is a novel RUNX1 target gene
Boyapati, A., Ren, B., & Zhang, D. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.06.107 · Cited by 8
Self-citationTahirov, T. H., Inoue-Bungo, T., Sasaki, M., Shiina, M., Kimura, K., Sato, K., Kumasaka, T., Yamamoto, M., Kamiya, N., & Ogata, K. (2001) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444901003900 · Cited by 8
Morii, E., Ogihara, H., Kanno, T., Kim, D., Nomura, S., Ito, Y., & Kitamura, Y. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0996 · Cited by 8
Mutational Analyses of the AML1 Gene in Patients with Myelodysplastic Syndrome
Imai, Y., Kurokawa, M., Izutsu, K., Hangaishi, A., Maki, K., Ogawa, S., Chiba, S., Mitani, K., & Hirai, H. (2002) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190290012155 · Cited by 7
Sasmono, R. T., & Hume, D. A. (2014) · ASM Press eBooks · doi:10.1128/9781555817671.ch4 · Cited by 7
Barat, C., & Rassart, É. (1998) · Virology · doi:10.1006/viro.1998.9435 · Cited by 7
C/ebpα represses the oncogenic Runx3–Myc axis in p53-deficient osteosarcoma development
Omori, K., Otani, S., Date, Y., Ueno, T., Ito, T., Umeda, M., & Ito, K. (2023) · Oncogene · doi:10.1038/s41388-023-02761-z · Cited by 6
Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia
Castilla, L. H., & Bushweller, J. H. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-3233-2_15 · Cited by 6
Mathur, A., Gangwar, A., & Saluja, D. (2023) · BMC Cancer · doi:10.1186/s12885-023-10818-1 · Cited by 6
Nuclear microenvironments support physiological control of gene expression
Stein, G. S., Lian, J. B., Montecino, M. A., Stein, J. L., van Wijnen, A. J., Javed, A., Pratap, J., Choi, J. Y., Zaidi, S. K., Gutierrez, S. E., et al. (2003) · Chromosome Research · doi:10.1023/a:1024943214431 · Cited by 6
Insight into Regulatory Factor Targeting to Transcriptionally Active Subnuclear Sites
Stein, G. S., van Wijnen, A. J., Stein, J. L., Lian, J. B., Javed, A., McNeil, S. M., & Pockwinse, S. M. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4680 · Cited by 6
A role for cadherins in cellular signaling and differentiation
Knudsen, K. A., Frankowski, C., Johnson, K. R., & Wheelock, M. J. (1998) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(1998)72:30/31+ · Cited by 88
Yonezawa, T., Takahashi, H., Hao, Y., Furukawa, C., Tsuchiya, A., Zhang, W., Fukushima, T., Fukuyama, T., Sawasaki, T., Kitamura, T., et al. (2023) · FEBS Journal · doi:10.1111/febs.16914 · Cited by 5
Herrera, J., Bensussen, A., García‐Gómez, M. L., Garay‐Arroyo, A., & Alvarez-Buylla, E. R. (2024) · npj Systems Biology and Applications · doi:10.1038/s41540-024-00469-8 · Cited by 5
Odaira, K., Yasuda, T., Okada, K., Shimooka, T., Kojima, Y., Noura, M., Tamura, S., Kurahashi, S., Iwamoto, E., Sanada, M., et al. (2022) · Cancer Science · doi:10.1111/cas.15641 · Cited by 5
MAPK p38alpha Kinase Influences Haematopoiesis in Embryonic Stem Cells
Štefková, K., Hanáčková, M., Kučera, J., Radaszkiewicz, K. A., Ambrůžová, B., Kubala, L., & Pachernı́k, J. (2019) · Stem Cells International · doi:10.1155/2019/5128135 · Cited by 5
Akashi, K. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1392.009 · Cited by 5
Tumor-associated macrophages: orchestrators of the tumor microenvironment
Echols, J. B., Meehan, A. W., Marotto, K., Ordonez, V., & Hildreth, B. E. (2026) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00834.2025 · Cited by 4
Transcription Factors That Regulate Macrophage Development and Function
Hume, D., & Himes, S. R. (2003) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-55742-2_2 · Cited by 5
Crystallization and preliminary X-ray analysis of the C/EBPβ C-terminal region in complex with DNA
Tahirov, T. H., Inoue-Bungo, T., Sasaki, M., Fujikawa, A., Kimura, K., Sato, K., Adachi, S., Kamiya, N., & Ogata, K. (2001) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444901003912 · Cited by 4
AML1 and AML1 Fusion Protein AML1-ETO in Myeloid Gene Regulation and Leukemogenesis
Zhang, D., Burel, S. A., Zhou, L., Hetherington, C. J., & Yuan, Y. (2001) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.2001.0391 · Cited by 4
Self-citationOrigin and Development of Microglia
Patro, N., & Patro, I. K. (2022) · Springer eBooks · doi:10.1007/978-981-16-8313-8_7 · Cited by 3
Adamaki, M., Vlahopoulos, S., Lambrou, G. Ι., Papavassiliou, A. G., & Moschovi, M. A. (2017) · Tumor Biology · doi:10.1177/1010428317694308 · Cited by 3
Stein, G. S., Lian, J. B., Stein, J. L., van Wijnen, A. J., Montecino, M. A., Javed, A., Pratap, J., Choi, J. Y., Zaidi, S. K., Gutierrez, S. E., et al. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10364 · Cited by 3
New insights into transcriptional and leukemogenic mechanisms of AML1-ETO and E2A fusion proteins
Li, J., Guo, C. H., Steinauer, N., & Zhang, J. (2016) · Frontiers in Biology · doi:10.1007/s11515-016-1415-1 · Cited by 3
Stein, G. S., Lian, J. B., Stein, J. L., van Wijnen, A. J., Javed, A., Zaidi, S. K., Shen, J., Pockwinse, S. M., Young, D. W., Montecino, M. A., et al. (2005) · Elsevier eBooks · doi:10.1016/b978-012252687-9/50022-x · Cited by 3
Effective leukemia-to-granulocyte induction by a cocktail of RUNX1, SPI1 and CEBPE
Xiang, G., Zhu, P., Zhang, L., Yu, S., Jiang, F., Wang, S., Wang, J., Dai, Y., Wang, S., Tan, Y., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217820 · Cited by 2
Nataraj, K., Schonfeld, M. P., Mah, S., Li, Z., Weinman, S. A., & Tikhanovich, I. (2025) · Hepatology Communications · doi:10.1097/hc9.0000000000000771 · Cited by 2
Wu, F., Song, T., Yao, Y., & Song, Y. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216203 · Cited by 2
Mechanisms of Secondary Leukemia Development Caused by Treatment with DNA Topoisomerase Inhibitors
Lomov, N. A., Viushkov, V. S., & Rubtsov, M. A. (2023) · Biochemistry (Moscow) · doi:10.1134/s0006297923070040 · Cited by 2
Blank-Stein, N., Mayer, M., & Mass, E. (2021) · Advances in immunology · doi:10.1016/bs.ai.2021.08.001 · Cited by 2
Elucidating the risk factors and oncogene drivers of acute myeloid leukemia
Sanya, D. R. A., & Onésime, D. (2025) · Human Cell · doi:10.1007/s13577-025-01294-9 · Cited by 1
Menezes, A. C., Deuitch, N. T., Pintuff, A., Zhen, T., Wincovitch, S., Öztürk, K., Carter, H. K., Ripperger, T., Godley, L. A., & Liu, P. (2026) · Blood Advances · doi:10.1182/bloodadvances.2026019984 · Cited by 1
Qu, F., Hui, M., Yang, F., Wan, W., Liu, N., Wu, X., He, Y., & Wang, X. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1775927 · Cited by 1
Rahmanian, N., Tarighi, P., Gharghabi, M., Torshabi, M., Tarfiei, G. A., Farsani, T. M., Ostad, S. N., & Ghahremani, M. H. (2017) · Europe PMC (PubMed Central) · Cited by 1
Prostaglandin E2 Regulates Bipotent Monocyte-Dendritic Progenitor Cell Lineage-Commitment
Singh, P., & Pelus, L. M. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10202-1 · Cited by 1
The role of the embryonic microenvironment in hematopoietic cell development
Haak, E. (2007) · RePub (Erasmus University Rotterdam) · Cited by 1
Signal transduction pathways mediated by colony stimulating factor-1 receptor
Luo, S., & Dexian, Z. (1998) · Chinese Science Bulletin · doi:10.1007/bf02884628 · Cited by 1
Coppersmith, H. J., Kim, H., & Klug, C. (2010) · Blood · doi:10.1182/blood.v116.21.4195.4195 · Cited by 1
Haemopoiesis, leukaemia & imatinib: c-fms, a novel target for small molecule inhibitor therapy.
Dewar, A. L. (2004) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)
The role of transcription factors in eosinophil differentiation
Baltus, G. E. (2002) · Utrecht University Repository (Utrecht University)
Analysis of senescence-like growth arrest induced by RUNX1 and its fusion derived oncoproteins
Wolyniec, K. (2008) · Enlighten: Theses (The University of Glasgow) · doi:10.5525/gla.thesis.578
Characterisation of the leukaemia-associated ETO homologues
Lindberg, S. R. (2006) · Lund University Publications (Lund University)
Aberrant Transcription Factors in AML
Friedman, A. D. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-322-6_2
Runx1 C-terminal Domains During Hematopoietic Development and Leukemogenesis: A Dissertation
Dowdy, C. R. (2012) · eScholarship@UMassChan · doi:10.13028/2mya-hk98
Pulikkan, J. A. (2008) · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.10298
the t(8;21) Fusion Protein Neurofibromatosis-1 Tumor Suppressor by Transcriptional Repression of the
Hiebert, S. W., Gutmann, D. H., Delwel, R., Clapp, D. W., Gao, M., Khalaf, W. F., & van de Locht, L. T. (2014)
Self-citationLoke, J. C. T., Ptasinska, A., Imperato, M. R., Assi, S. A., Cauchy, P., Cowell, I. G., Heidenreich, O. T., Raghavan, M., Delwel, R., Cockerill, P., et al. (2016) · Klinische Pädiatrie · doi:10.1055/s-0036-1582520
Studies on the core binding factor complex in patients with acute myeloid leukaemia
Langabeer, S. E. (2002) · OpenGrey (Institut de l'Information Scientifique et Technique)
Nanan, K. K. (2014) · QSpace (Queen's University Library)
Ridley, M. L. (2017) · University of Birmingham Institutional Research Archive (University of Birmingham)
Therapeutic targeting of the leukaemic fusion genes
Issa, H. (2019)
Regulation of the LIFR and gp130 genes by the RUNX1 transcription factor
Qadi, A. (2012) · UTAS Research Repository · doi:10.25959/23205896
An overview of fibroblast growth factor 23 and its role in kidney function
Alivand, N., Molaee, H., Assarroudi, M., Moazam, A. F., Dehghan, S., & Alivand, S. (2023) · Journal of Renal Endocrinology · doi:10.34172/jre.2023.25100
Huang, T., Yang, M., Dong, K., Xu, M., Liu, J., Chen, Z., Zhu, S., Chen, W., Yin, J., Jin, K., et al. (2020) · Figshare · doi:10.6084/m9.figshare.11986701
Huang, T., Yang, M., Dong, K., Xu, M., Liu, J., Chen, Z., Zhu, S., Chen, W., Yin, J., Jin, K., et al. (2020) · Figshare · doi:10.6084/m9.figshare.11986728
Huang, T., Yang, M., Dong, K., Xu, M., Liu, J., Chen, Z., Zhu, S., Chen, W., Yin, J., Jin, K., et al. (2020) · Figshare · doi:10.6084/m9.figshare.11986722
Huang, T., Yang, M., Dong, K., Xu, M., Liu, J., Chen, Z., Zhu, S., Chen, W., Yin, J., Jin, K., et al. (2020) · Figshare · doi:10.6084/m9.figshare.11986692
Huang, T., Yang, M., Dong, K., Xu, M., Liu, J., Chen, Z., Zhu, S., Chen, W., Yin, J., Jin, K., et al. (2020) · Figshare · doi:10.6084/m9.figshare.11986710
Mechanisms for the development of therapy-related leukaemia caused by topoisomerase inhibitors
Lomov, N. A., Viushkov, V. S., & Rubtsov, M. A. (2023) · Biochemistry (Moscow) · doi:10.31857/s0320972523070047
Kimura, M., Ogawa, Y., Motohashi, S., & Imamoto, N. (2025) · FEBS Letters · doi:10.1002/1873-3468.70020
Huang, T., Yang, M., Dong, K., Xu, M., Liu, J., Chen, Z., Zhu, S., Chen, W., Yin, J., Jin, K., et al. (2020) · Figshare · doi:10.6084/m9.figshare.11986716
Mathur, A., Gangwar, A., & Saluja, D. (2023) · Figshare · doi:10.6084/m9.figshare.22729300
Mathur, A., Gangwar, A., & Saluja, D. (2023) · Figshare · doi:10.6084/m9.figshare.22729303
Mathur, A., Gangwar, A., & Saluja, D. (2023) · Figshare · doi:10.6084/m9.figshare.22729297
Terret-Guéry, L. (2010) · theses.fr (ABES) · doi:10.70675/005598efzec21z43f2zb22ez300245496e37
Jun regulates monocyte-derived macrophage accumulation and tumour progression
Delfini, M. (2019) · theses.fr (ABES) · doi:10.70675/afce218czd47fz4e81za3d3z2d2a848304d4
RNA Interference in Haematopoietic and Leukaemic Cells
Thomas, M., Martinez-Soria, N., & Heidenreich, O. T. (2007) · Springer eBooks · doi:10.1007/1-4020-5252-9_2
Metadata
- Authors
- Zhang, D.-E., Hetherington, C. J., Meyers, S., Rhoades, K. L., Larson, C. J., Chen, H.-M., Hiebert, S. W., & Tenen, D. G.
- Affiliations
- Harvard University (US)
- St. Jude Children's Research Hospital (US)
- Salk Institute for Biological Studies (US)
- Division of Hematology/Oncology, Department of Medicine, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1996-03-01
- Volume
- 16
- Issue
- 3
- Pages
- 1231-1240
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC231105
- OpenAlex
- W2165787335
- Cited by
- 396
- References
- 82
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 10 · 2022: 7 · 2021: 3 · 2020: 2 · 2019: 8 · 2018: 9 · 2017: 14 · 2016: 7 · 2015: 7 · 2014: 10 · 2013: 11 · 2012: 8
- FWCI
- 10.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- McKnight Foundation
- St. Jude Children's Research Hospital (CA21765)
- American Lebanese Syrian Associated Charities (CA 21765)
- National Institutes of Health (CA21765))
- National Cancer Institute (CA64140, CA 41456, CA/AI59589, R01CA041456, R01CA064140, P30CA021765)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Keywords
- C/EBP, RUNX1, macrophage colony-stimulating factor receptor, transcriptional activation, CBFβ, monocyte differentiation, acute myeloid leukemia, PU.1, hematopoietic transcription factors
- MeSH terms
- Animals, Base Sequence, Cell Line, DNA-Binding Proteins, Humans, Molecular Sequence Data, Monocytes, Neoplasm Proteins, Nuclear Proteins, Promoter Regions, Genetic, Protein Binding, Proto-Oncogene Proteins, Transcription Factors, Signal Transduction, Receptor, Macrophage Colony-Stimulating Factor, CCAAT-Enhancer-Binding Proteins, Core Binding Factor Alpha 2 Subunit
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
