The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
The Drosophila MSL Complex Acetylates Histone H4 at Lysine 16, a Chromatin Modification Linked to Dosage Compensation
Open accessAbstract
In Drosophila, dosage compensation-the equalization of most X-linked gene products in males and females-is achieved by a twofold enhancement of the level of transcription of the X chromosome in males relative to each X chromosome in females. A complex consisting of at least five gene products preferentially binds the X chromosome at numerous sites in males and results in a significant increase in the presence of a specific histone isoform, histone 4 acetylated at lysine 16. Recently, RNA transcripts (roX1 and roX2) encoded by two different genes have also been found associated with the X chromosome in males. We have partially purified a complex containing MSL1, -2, and -3, MOF, MLE, and roX2 RNA and demonstrated that it exclusively acetylates H4 at lysine 16 on nucleosomal substrates. These results demonstrate that the MSL complex is responsible for the specific chromatin modification characteristic of the X chromosome in Drosophila males.
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The histone H4 acetyltransferase MOF uses a C 2 HC zinc finger for substrate recognition
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The diverse functions of histone acetyltransferase complexes
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Regulatory Enhancer–Core-Promoter Communication via Transcription Factors and Cofactors
Zabidi, M. A., & Stark, A. (2016) · Trends in Genetics · doi:10.1016/j.tig.2016.10.003 · Cited by 228
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Metadata
- Authors
- Smith, E. R., Pannuti, A., Gu, W., Steurnagel, A., Cook, R. G., Allis, C. D., & Lucchesi, J. C.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2000-01-01
- Volume
- 20
- Issue
- 1
- Pages
- 312-318
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2140450002
- Cited by
- 316
- References
- 45
- FWCI
- 8.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Smith, E. R., Pannuti, A., Gu, W., Steurnagel, A., Cook, R. G., Allis, C. D., & Lucchesi, J. C. (2000). The Drosophila MSL Complex Acetylates Histone H4 at Lysine 16, a Chromatin Modification Linked to Dosage Compensation. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.20.1.312-318.2000
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