The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
The histone H4 acetyltransferase MOF uses a C 2 HC zinc finger for substrate recognition
Open accessAbstract
Site‐specific acetylation of histone H4 by MOF is central to establishing the hyperactive male X chromosome in Drosophila . MOF belongs to the MYST family of histone acetyltransferases (HATs) characterized by an unusual C 2 HC‐type zinc finger close to their HAT domains. The function of these rare zinc fingers is unknown. We found that this domain is essential for HAT activity, in addition to the established catalytic domain. MOF uses its zinc finger to contact the globular part of the nucleosome as well as the histone H4 N‐terminal tail substrate. Point mutations that leave the zinc‐finger structure intact nevertheless abolish its interaction with the nucleosome. Our data document a novel role of the C 2 HC‐type finger in nucleosome binding and HAT activity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The language of covalent histone modifications
Strahl, B. D., & Allis, C. D. (2000) · Nature · doi:10.1038/47412 · Cited by 8,679
Paro, R., & Hogness, D. S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.1.263 · Cited by 569
Akhtar, A., & Becker, P. B. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80431-1 · Cited by 481
Self-citationLuger, K., Rechsteiner, T. J., Flaus, A. J., Waye, M. M. Y., & Richmond, T. J. (1997) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.1235 · Cited by 467
Hilfiker, A. (1997) · The EMBO Journal · doi:10.1093/emboj/16.8.2054 · Cited by 459
Chromodomains are protein–RNA interaction modules
Akhtar, A., Zink, D., & Becker, P. B. (2000) · Nature · doi:10.1038/35030169 · Cited by 385
Self-citationThe many HATs of transcription coactivators
BROWN, C., LECHNER, T., HOWE, L., & WORKMAN, J. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01516-9 · Cited by 348
Modulation of RNA function by aminoglycoside antibiotics
Schroeder, R. (2000) · The EMBO Journal · doi:10.1093/emboj/19.1.1 · Cited by 325
Smith, E. R., Pannuti, A., Gu, W., Steurnagel, A., Cook, R. G., Allis, C. D., & Lucchesi, J. C. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.1.312-318.2000 · Cited by 316
DOSAGE COMPENSATION IN DROSOPHILA
Baker, B. S., Gorman, M., & Marín, I. (1994) · Annual Review of Genetics · doi:10.1146/annurev.ge.28.120194.002423 · Cited by 242
Cited by
Epigenetics and the biological definition of gene×environment interactions
Meaney, M. J. (2010) · Child Development · doi:10.1111/j.1467-8624.2009.01381.x · Cited by 1,239
Prabakaran, S., Lippens, G., Steen, H., & Gunawardena, J. (2012) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1185 · Cited by 335
Protein acetylation in metabolism – metabolites and cofactors
Menzies, K. J., Zhang, H., Katsyuba, E., & Auwerx, J. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.181 · Cited by 331
DNA methylation: A mechanism for embedding early life experiences in the genome
Szyf, M., & Bick, J. (2013) · Child Development · doi:10.1111/j.1467-8624.2012.01793.x · Cited by 251
Epigenetics at the crossroads between genes, environment and resilience in anxiety disorders
Schiele, M. A., & Domschke, K. (2018) · Genes, Brain and Behavior · doi:10.1111/gbb.12423 · Cited by 233
Metadata
- Authors
- Akhtar, A., & Becker, P. B.
- Venue
- EMBO reports
- Published
- 2001-02
- Volume
- 2
- Issue
- 2
- Pages
- 113-118
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W1988754209
- Cited by
- 632
- References
- 25
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The histone H4 acetyltransferase MOF uses a C 2 HC zinc finger for substrate recognition. https://app.cochat.ai/papers/10.1093/embo-reports/kve022
- The paper
- Akhtar, A., & Becker, P. B. (2001). The histone H4 acetyltransferase MOF uses a C 2 HC zinc finger for substrate recognition. EMBO reports. https://doi.org/10.1093/embo-reports/kve022
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
