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Regulatory Networks Revealed by Transcriptional Profiling of Damaged Saccharomyces cerevisiae Cells: Rpn4 Links Base Excision Repair with Proteasomes
Open accessAbstract
Exposure to carcinogenic alkylating agents, oxidizing agents, and ionizing radiation modulates transcript levels for over one third of Saccharomyces cerevisiae's 6,200 genes. Computational analysis delineates groups of coregulated genes whose upstream regions bear known and novel regulatory sequence motifs. One group of coregulated genes contain a number of DNA excision repair genes (including the MAG1 3-methyladenine DNA glycosylase gene) and a large selection of protein degradation genes. Moreover, transcription of these genes is modulated by the proteasome-associated protein Rpn4, most likely via its binding to MAG1 upstream repressor sequence 2-like elements, that turn out to be almost identical to the recently identified proteasome-associated control element (G. Mannhaupt, R. Schnall, V. Karpov, I. Vetter, and H. Feldmann, FEBS Lett. 450:27-34, 1999). We have identified a large number of genes whose transcription is influenced by Rpn4p.
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“Indeed, approximately 5% of the yeast genome is upregulated in response to various DNA-damaging agents (15, 23, 24).”
From A Role for Checkpoint Kinase-Dependent Rad26 Phosphorylation in Transcription-Coupled DNA Repair in Saccharomyces cerevisiae (2010) · cites this paper as [23]
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Metadata
- Authors
- Jelinsky, S. A., Estep, P., Church, G. M., & Samson, L. D.
- Affiliations
- Harvard University (US)
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2000-11
- Volume
- 20
- Issue
- 21
- Pages
- 8157-8167
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC86425
- OpenAlex
- W2118567506
- Cited by
- 335
- References
- 41
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 10 · 2018: 2 · 2017: 3 · 2016: 9 · 2015: 6 · 2014: 8 · 2013: 10 · 2012: 8
- FWCI
- 11.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion)
- Funders
- National Institutes of Health
- Office of Naval Research (N00014-97-1-0865, N00014)
- National Human Genome Research Institute (P01-HG0132)
- National Cancer Institute (R01-CA5502, CA09078, T32CA009078, F32CA081744)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- Rpn4, Saccharomyces cerevisiae, DNA base excision repair, MAG1, 3-methyladenine DNA glycosylase, proteasome, transcriptional regulation, co-regulated genes, DNA damage response, gene expression profiling
- MeSH terms
- Algorithms, Computer Simulation, Cysteine Endopeptidases, DNA Repair, DNA-Binding Proteins, Dose-Response Relationship, Drug, Kinetics, Methyl Methanesulfonate, Multienzyme Complexes, Mutagens, N-Glycosyl Hydrolases, RNA, Messenger, Saccharomyces cerevisiae, Time Factors, Transcription Factors, Transcription, Genetic, Reproducibility of Results, Models, Statistical, Cluster Analysis, Oligonucleotide Array Sequence Analysis, Saccharomyces cerevisiae Proteins, DNA Glycosylases, Proteasome Endopeptidase Complex
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