Church, George M.

RNA-Guided Human Genome Engineering via Cas9

Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 9,210

A Deep Learning Approach to Antibiotic Discovery

Stokes, J. M., Yang, K., Swanson, K., Jin, W., Cubillos-Ruiz, A., Donghia, N. M., MacNair, C. R., French, S., Carfrae, L. A., Bloom-Ackermann, Z., et al. (2020) · Cell

Computational Drug Discovery MethodsMicrobial Natural Products and Biosynthesis

Cited by 2,463

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

Mali, P., Aach, J., Stranges, P. B., Esvelt, K. M., Moosburner, M., Kosuri, S., Yang, L., & Church, G. M. (2013) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,752

Highly efficient Cas9-mediated transcriptional programming

Chavez, A., Scheiman, J., Vora, S., Pruitt, B. W., Tuttle, M., P R Iyer, E., Lin, S., Kiani, S., Guzman, C. D., Wiegand, D. J., et al. (2015) · Nature Methods

CRISPR and Genetic EngineeringPluripotent Stem Cells Research

Cited by 1,622

Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems

DiCarlo, J. E., Norville, J. E., Mali, P., Rios, X., Aach, J., & Church, G. M. (2013) · Nucleic Acids Research

CRISPR and Genetic EngineeringFungal and yeast genetics research

Cited by 1,566

Programming cells by multiplex genome engineering and accelerated evolution

Wang, H. H., Isaacs, F. J., Carr, P. A., Sun, Z. Z., Xu, G., Forest, C. R., & Church, G. M. (2009) · Nature

CRISPR and Genetic EngineeringMicrobial Metabolic Engineering and Bioproduction

Cited by 1,529

Next-Generation Digital Information Storage in DNA

Church, G. M., Gao, Y., & Kosuri, S. (2012) · Science

DNA and Biological ComputingAdvanced biosensing and bioanalysis techniques

Cited by 1,441

Assessing computational tools for the discovery of transcription factor binding sites

Tompa, M., Li, N., Bailey, T. L., Church, G. M., De Moor, B., Eskin, E., Favorov, A. V., Frith, M. C., Fu, Y., Kent, W. J., et al. (2005) · Nature Biotechnology

Genomics and Chromatin DynamicsGenomics and Phylogenetic Studies

Cited by 1,268

Human Genome Sequencing Using Unchained Base Reads on Self-Assembling DNA Nanoarrays

Drmanac, R., Sparks, A. B., Callow, M. J., Halpern, A. L., Burns, N. L., Kermani, B. G., Carnevali, P., Nazarenko, I., Nilsen, G. B., Yeung, G., et al. (2010) · Science

Advanced biosensing and bioanalysis techniquesGenomics and Phylogenetic Studies

Cited by 1,212

Cas9 as a versatile tool for engineering biology

Mali, P., Esvelt, K. M., & Church, G. M. (2013) · Nature Methods

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,197

Unified rational protein engineering with sequence-based deep representation learning

Alley, E. C., Khimulya, G., Biswas, S., AlQuraishi, M., & Church, G. M. (2019) · Nature Methods

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 1,131

In vivo gene editing in dystrophic mouse muscle and muscle stem cells

Tabebordbar, M., Zhu, K., Cheng, J. K. W., Chew, W. L., Widrick, J. J., Yan, W. X., Maesner, C., Wu, E. Y., Xiao, R., Ran, F. A., et al. (2016) · Science

CRISPR and Genetic EngineeringMuscle Physiology and Disorders

Cited by 1,046

Highly Multiplexed Subcellular RNA Sequencing in Situ

Lee, J. H., Daugharthy, E. R., Scheiman, J., Kalhor, R., Yang, J. L., Ferrante, T. C., Terry, R., Jeanty, S. S. F., Li, C., Amamoto, R., et al. (2014) · Science

Single-cell and spatial transcriptomicsRNA Research and Splicing

Cited by 973

Cover Picture: Recoding the Genetic Code with Selenocysteine (Angew. Chem. Int. Ed. 1/2014)

Bröcker, M. J., Ho, J. M. L., Church, G. M., Söll, D., & O'Donoghue, P. (2014) · Angewandte Chemie International Edition

RNA and protein synthesis mechanismsOrganoselenium and organotellurium chemistry

Cited by 911

Heritable genome editing in C. elegans via a CRISPR-Cas9 system

Friedland, A. E., Tzur, Y. B., Esvelt, K. M., Colaiácovo, M. P., Church, G. M., & Calarco, J. A. (2013) · Nature Methods

CRISPR and Genetic EngineeringAnimal Genetics and Reproduction

Cited by 899

Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism

Scheiman, J., Luber, J. M., Chavkin, T. A., MacDonald, T., Tung, A., Pham, L.-D., Wibowo, M. C., Wurth, R. C., Punthambaker, S., Tierney, B. T., et al. (2019) · Nature Medicine

Gut microbiota and healthProbiotics and Fermented Foods

Cited by 892

Functional characterization of the antibiotic resistance reservoir in the human microflora

Sommer, M. O. A., Dantas, G., & Church, G. M. (2009) · Science

Antibiotic Resistance in BacteriaGut microbiota and health

Cited by 878

Large-scale de novo DNA synthesis: technologies and applications

Kosuri, S., & Church, G. M. (2014) · Nature Methods

CRISPR and Genetic EngineeringDNA and Nucleic Acid Chemistry

Cited by 869

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

Wang, G., McCain, M. L., Yang, L., He, A., Pasqualini, F. S., Agarwal, A., Yuan, H., Jiang, D., Zhang, D., Zangi, L., et al. (2014) · Nature Medicine

Pluripotent Stem Cells ResearchMitochondrial Function and Pathology

Cited by 837

Reprogramming to recover youthful epigenetic information and restore vision

Lu, Y., Brommer, B., Tian, X., Krishnan, A., Meer, M., Wang, C., Vera, D. L., Zeng, Q., Yu, D., Bonkowski, M. S., et al. (2020) · Nature

Epigenetics and DNA MethylationPluripotent Stem Cells Research

Cited by 820

Extensive sequencing of seven human genomes to characterize benchmark reference materials

Zook, J. M., Catoe, D., McDaniel, J., Vang, L., Spies, N., Sidow, A., Weng, Z., Liu, Y., Mason, C. E., Alexander, N., et al. (2016) · Scientific Data

Genomics and Phylogenetic StudiesGenomic variations and chromosomal abnormalities

Cited by 811

Optical control of mammalian endogenous transcription and epigenetic states

Konermann, S., Brigham, M. D., Trevino, A. E., Hsu, P. D., Heidenreich, M., Cong, L., Platt, R. J., Scott, D. A., Church, G. M., & Zhang, F. (2013) · Nature

Photoreceptor and optogenetics researchCRISPR and Genetic Engineering

Cited by 803

Orthogonal Cas9 proteins for RNA-guided gene regulation and editing

Esvelt, K. M., Mali, P., Braff, J. L., Moosburner, M., Yaung, S. J., & Church, G. M. (2013) · Nature Methods

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 786

Meta-analysis of age-related gene expression profiles identifies common signatures of aging

de Magalhães, J. P., Curado, J., & Church, G. M. (2009) · Bioinformatics

Genetics, Aging, and Longevity in Model OrganismsGene expression and cancer classification

Cited by 737