The DOI matches its Crossref record; 71 of the 72 references it cites were found in a registry or an index, and 1 are not checked yet.
Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3
Open accessAbstract
The c-Jun NH(2)-terminal kinase (JNK) group of mitogen-activated protein kinases (MAPKs) is activated in response to the treatment of cells with inflammatory cytokines and by exposure to environmental stress. JNK activation is mediated by a protein kinase cascade composed of a MAPK kinase and a MAPK kinase kinase. Here we describe the molecular cloning of a putative molecular scaffold protein, JIP3, that binds the protein kinase components of a JNK signaling module and facilitates JNK activation in cultured cells. JIP3 is expressed in the brain and at lower levels in the heart and other tissues. Immunofluorescence analysis demonstrated that JIP3 was present in the cytoplasm and accumulated in the growth cones of developing neurites. JIP3 is a member of a novel class of putative MAPK scaffold proteins that may regulate signal transduction by the JNK pathway.
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“The JIPs display a highly polarized subcellular localization at the tips of neuronal cell processes and in extended projections from the surface of insulinoma cells (Meyer et al. 1999; Yasuda et al. 1999; Kelkar et al. 2000).”
From Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules (2001) · cites this paper as Kelkar et al. 2000
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“JIP-3 (also known as JSAP) can form oligomeric complexes with itself and JIP-2 but has no sequence relationship to JIP-1 or JIP-2 (Ito et al. 1999; Kelkar et al. 2000).”
From Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules (2001) · cites this paper as Kelkar et al. 2000
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Cites
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Signal transduction by the JNK group of MAP kinases
Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
Pearson, G. W., Robinson, F. L., Gibson, T. B., Xu, B.-E., Karandikar, M. S., Berman, K. S., & Cobb, M. H. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.2.0428 · Cited by 4,111
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“JSAP1/JIP3, like SAPKb, is localized selectively in brain and heart (a small amount of JSAP1/JIP3 message is detectable in lung) (136, 155).”
BackgroundInfluentialKinesin superfamily motor proteins and intracellular transport
Hirokawa, N., Noda, Y., Tanaka, Y., & Niwa, S. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2774 · Cited by 1,859
“Although JIPs function primarily as scaffolding proteins to mediate the JNK signalling cascade by directly binding to MAPK, MAPK kinase (MAPKK) and MAPK kinase kinase (MAPKKK”
BackgroundThe JNK signal transduction pathway
Weston, C. R. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(01)00258-1 · Cited by 1,551
Metadata
- Authors
- Kelkar, N., Gupta, S., Dickens, M., & Davis, R. J.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Davis, Roger J.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2000-02-01
- Volume
- 20
- Issue
- 3
- Pages
- 1030-1043
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC85220
- OpenAlex
- W2147103035
- Cited by
- 281
- References
- 71
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 7 · 2021: 5 · 2020: 6 · 2019: 4 · 2018: 8 · 2017: 10 · 2016: 7 · 2015: 9 · 2014: 8 · 2013: 7 · 2012: 6
- FWCI
- 8.62
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Molecular and Cellular Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Keywords
- JIP3, JNK, c-Jun NH2-terminal kinase, MAPK signaling, MAPK kinase, MAPK kinase kinase, growth cones, neurite development, signal transduction regulation, brain expression
- MeSH terms
- Aging, Amino Acid Sequence, Animals, Brain, Cells, Cultured, Cloning, Molecular, Enzyme Activation, Female, Embryonic and Fetal Development, Male, Molecular Sequence Data, Nerve Tissue Proteins, Neurons, Recombinant Proteins, Signal Transduction, Gene Library, Sequence Alignment, Sequence Homology, Amino Acid, Gene Expression Regulation, Developmental, Protein Isoforms, Mitogen-Activated Protein Kinases, MAP Kinase Kinase Kinases, JNK Mitogen-Activated Protein Kinases, Adaptor Proteins, Signal Transducing, Mice
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