Requirement of the JIP1 scaffold protein for stress-induced JNK activation
Open accessAbstract
The c-Jun N-terminal kinase (JNK) signal transduction pathway is activated in response to the exposure of cells to environmental stress. Components of the JNK signaling pathway interact with the JIP1 scaffold protein. JIP1 is located in the neurites of primary hippocampal neurons. However, in response to stress, JIP1 accumulates in the soma together with activated JNK and phosphorylated c-Jun. Disruption of the Jip1 gene in mice by homologous recombination prevented JNK activation caused by exposure to excitotoxic stress and anoxic stress in vivo and in vitro. These data show that the JIP1 scaffold protein is a critical component of a MAP-kinase signal transduction pathway.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
More physiological studies show that JIP1 is required for JNK activation and is inhibitory only when overexpressed.
“However, it is now clear from more physiologically relevant studies that JIP1 is required for activation of JNK (Jaeschke et al., 2004; Morel et al., 2010; Whitmarsh et al., 2001), and is only inhibitory when overexpressed.”
From Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases (2012) · cites this paper as Whitmarsh et al., 2001
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,290 · see citing works
Self-citationSignal transduction by the JNK group of MAP kinases
Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237 · see citing works
Self-citationDérijard, B., Hibi, M., Wu, I.-H., Barrett, T., Su, B., Deng, T., Karin, M., & Davis, R. J. (1994) · Cell · doi:10.1016/0092-8674(94)90380-8 · Cited by 3,188 · see citing works
Self-citationThe stress-activated protein kinase subfamily of c-Jun kinases
Kyriakis, J. M., Banerjee, P. T., Nikolakaki, E., Dai, T., Rubie, E. A., Ahmad, M. F., Avruch, J., & Woodgett, J. R. (1994) · Nature · doi:10.1038/369156a0 · Cited by 2,601 · see citing works
Raingeaud, J., Gupta, S., Rogers, J. S., Dickens, M., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7420 · Cited by 2,244 · see citing works
Self-citationA protein related to extracellular matrix proteins deleted in the mouse mutant reeler
D'Arcangelo, G., G. Miao, G., Chen, S.-C., Scares, H. D., Morgan, J. I., & Curran, T. (1995) · Nature · doi:10.1038/374719a0 · Cited by 1,748 · see citing works
Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway
Tournier, C., Hess, P., Yang, D. D., Xu, J., Turner, T. K., Nimnual, A., Bar-Sagi, D., Jones, S. N., Flavell, R. A., & Davis, R. J. (2000) · Science · doi:10.1126/science.288.5467.870 · Cited by 1,728 · see citing works
Self-citationG PROTEIN–COUPLED RECEPTOR KINASES
Pitcher, J. A., Freedman, N. J., & Lefkowitz, R. J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.653 · Cited by 1,379 · see citing works
Organization and regulation of mitogen-activated protein kinase signaling pathways
Garrington, T. P., & Johnson, G. L. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80028-3 · Cited by 1,275 · see citing works
Trommsdorff, M., Gotthardt, M., Hiesberger, T., Shelton, J., Stockinger, W., Nimpf, J., Hammer, R. E., Richardson, J. A., & Herz, J. (1999) · Cell · doi:10.1016/s0092-8674(00)80782-5 · Cited by 1,261 · see citing works
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
Yang, D. D., Kuan, C.-Y., Whitmarsh, A. J., Rinócn, M., Zheng, T. S., Davis, R. J., RAKIC, P. T., & Flavell, R. A. (1997) · Nature · doi:10.1038/39899 · Cited by 1,230 · see citing works
Self-citationβ-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3
McDonald, P. H., Chow, C.-W., Miller, W. E., Laporte, S. A., Field, M. E., Lin, F., Davis, R. J., & Lefkowitz, R. J. (2000) · Science · doi:10.1126/science.290.5496.1574 · Cited by 818 · see citing works
Self-citationBehrens, A., Sibilia, M. C., & Wagner, E. F. (1999) · Nature Genetics · doi:10.1038/6854 · Cited by 676 · see citing works
A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway
Dickens, M., Rogers, J. S., Cavanagh, J., Raitano, A., Xia, Z., Halpern, J. R., Greenberg, M. E., Sawyers, C. L., & Davis, R. J. (1997) · Science · doi:10.1126/science.277.5326.693 · Cited by 675 · see citing works
Self-citationA Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation
Whitmarsh, A. J., Cavanagh, J., Tournier, C., Yasuda, J., & Davis, R. J. (1998) · Science · doi:10.1126/science.281.5383.1671 · Cited by 652 · see citing works
Self-citationCargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules
Verhey, K. J., Meyer, D., Deehan, R., Blenis, J., Schnapp, B. J., Rapoport, T. A., & Margolis, B. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.5.959 · Cited by 609 · see citing works
The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins
Yasuda, J., Whitmarsh, A. J., Cavanagh, J., Sharma, M., & Davis, R. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.10.7245 · Cited by 458 · see citing works
Self-citationStructural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals
Whitmarsh, A. J., & Davis, R. J. (1998) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01309-7 · Cited by 387 · see citing works
Self-citationTournier, C., Dong, C., Turner, T. K., Jones, S. N., Flavell, R. A., & Davis, R. J. (2001) · Genes & Development · doi:10.1101/gad.888501 · Cited by 358 · see citing works
Self-citationTopological characteristics of helical repeat protein
Groves, M. R., & Barford, D. (1999) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(99)80052-9 · Cited by 331 · see citing works
Kinesin-Dependent Axonal Transport Is Mediated by the Sunday Driver (SYD) Protein
Bowman, A. B., Kamal, A., Ritchings, B. W., Philp, A. V., McGrail, M. A., Gindhart, J. G., & Goldstein, L. S. B. (2000) · Cell · doi:10.1016/s0092-8674(00)00162-8 · Cited by 331 · see citing works
JNK is required for effector T-cell function but not for T-cell activation
Dong, C., Yang, D. D., Tournier, C., Whitmarsh, A. J., Xu, J., Davis, R. J., & Flavell, R. A. (2000) · Nature · doi:10.1038/35011091 · Cited by 328 · see citing works
Self-citationStress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3
Nishina, H., Fischer, K., Radvanyi, L. G., Shahinian, A., Hakem, R., Rubie, E. A., Bernstein, A., Mak, T. W., Woodgett, J. R., & Penninger, J. M. (1997) · Nature · doi:10.1038/385350a0 · Cited by 323 · see citing works
Expanding roles for β-arrestins as scaffolds and adapters in GPCR signaling and trafficking
Miller, W. E., & Lefkowitz, R. J. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00190-3 · Cited by 322 · see citing works
Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3
Kelkar, N., Gupta, S., Dickens, M., & Davis, R. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.1030-1043.2000 · Cited by 281 · cited 5× · see citing works
“JIP1, JIP2, and JIP3 antibodies have been described (Yasuda et al. 1999; Kelkar et al. 2000).”
BackgroundMethodResultInfluentialIto, M., Yoshioka, K., Akechi, M., Yamashita, S., Takamatsu, N., Sugiyama, K., Hibi, M., Nakabeppu, Y., Shiba, T., & Yamamoto, K.-I. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.11.7539 · Cited by 279 · see citing works
Pheromone response, mating and cell biology
Elion, E. A. (2000) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(00)00143-0 · Cited by 276 · see citing works
Watson, F. L., Heerssen, H. M., Moheban, D. B., Lin, M. Z., Sauvageot, C. M., Bhattacharyya, A., Pomeroy, S. L., & Segal, R. A. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-18-07889.1999 · Cited by 272 · see citing works
Yang, D., Tournier, C., Wysk, M., Lu, H., Xu, J., Davis, R. J., & Flavell, R. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3004 · Cited by 271 · see citing works
Self-citationThe reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2
Stockinger, W., Brandes, C., Fasching, D., Hermann, M., Gotthardt, M., Herz, J., Schneider, W. J., & Nimpf, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004119200 · Cited by 239 · cited 2× · see citing works
“It has been reported that the PTB domain of JIP1 interacts with members of the LDL receptor-related group of proteins (Stockinger et al. 2000).”
BackgroundMethodXia, Y., Wu, Z., Su, B., Murray, B. W., & Karin, M. (1998) · Genes & Development · doi:10.1101/gad.12.21.3369 · Cited by 203 · see citing works
Ganiatsas, S., Kwee, L., Fujiwara, Y., Perkins, A. C., Ikeda, T., Labow, M., & Zon, L. I. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6881 · Cited by 193 · see citing works
The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes
Waeber, G., Delplanque, J., Bonny, C., Mooser, V., Steinmann, M., Widmann, C., Maillard, A. M., Judith Miklossy, A., Christian Dina, C., Hani, E. H., et al. (2000) · Nature Genetics · doi:10.1038/73523 · Cited by 182 · see citing works
Trk Receptors Function As Rapid Retrograde Signal Carriers in the Adult Nervous System
Bhattacharyya, A., Watson, F. L., Bradlee, T. A., Pomeroy, S. L., Stiles, C. D., & Segal, R. A. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-18-07007.1997 · Cited by 182 · see citing works
Mahanty, S. K., Wang, Y., Farley, F. W., & Elion, E. A. (1999) · Cell · doi:10.1016/s0092-8674(00)81978-9 · Cited by 157 · see citing works
IB1, a JIP-1-related Nuclear Protein Present in Insulin-secreting Cells
Bonny, C., NICOD, P. H., & Waeber, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.4.1843 · Cited by 139 · see citing works
Meyer, D., Liu, A., & Margolis, B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.49.35113 · Cited by 126 · see citing works
IB1 Reduces Cytokine-induced Apoptosis of Insulin-secreting Cells
Bonny, C., Oberson, A., Steinmann, M., Schorderet, D. F., NICOD, P. H., & Waeber, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m908297199 · Cited by 122 · see citing works
Nath, R., Probert, A. W., McGinnis, K., et al. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71010186.x · Cited by 97 · see citing works
Aging and glucose homeostasis in C57BL/6J male mice
Leiter, E. H., Premdas, F. H., Harrison, D. E., & Lipson, L. G. (1988) · The FASEB Journal · doi:10.1096/fasebj.2.12.3044905 · Cited by 93 · see citing works
Role of Founder Cell Deficit and Delayed Neuronogenesis in Microencephaly of the Trisomy 16 Mouse
Haydar, T. F., Nowakowski, R. S., Yarowsky, P., & Krueger, B. K. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04156.2000 · Cited by 83 · see citing works
Self-citationCheng, J., Yang, J., Xia, Y., Karin, M., & Su, B. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.7.2334-2342.2000 · Cited by 77 · see citing works
cDNA Cloning and Mapping of a Novel Islet-Brain/JNK-Interacting Protein
Negri, S., Oberson, A., Steinmann, M., Sauser, C., NICOD, P. H., Waeber, G., Schorderet, D. F., & Bonny, C. (2000) · Genomics · doi:10.1006/geno.2000.6129 · Cited by 67 · see citing works
Swat, W., Fujikawa, K., Ganiatsas, S., Yang, D., Xavier, R. J., Harris, N. L., Davidson, L., Ferrini, R., Davis, R. J., Labow, M., et al. (1998) · Immunity · doi:10.1016/s1074-7613(00)80567-1 · Cited by 67 · see citing works
Self-citationKainate induces apoptosis in neurons
Simonian, N. A., Getz, R. L., Leveque, J., et al. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00141-8 · Cited by 67 · see citing works
Pellet, J., Haefliger, J., Staple, J. K., Widmann, C., Welker, E., Hirling, H., Bonny, C., Nicod, P., Catsicas, S., Waeber, G., et al. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00945.x · Cited by 55 · see citing works
Hollenbeck, P. J. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.5.f25 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The JNK signal transduction pathway
Weston, C. R., & Davis, R. J. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.001 · Cited by 1,021 · see citing works
Self-citationAn essential role of the JIP1 scaffold protein for JNK activation in adipose tissue
Jaeschke, A., Czech, M. P., & Davis, R. J. (2004) · Genes & Development · doi:10.1101/gad.1216504 · Cited by 121 · see citing works
Self-citationDocking Interactions in the c-Jun N-terminal Kinase Pathway
Mooney, L. M., & Whitmarsh, A. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311841200 · Cited by 73 · see citing works
Self-citationStructural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases
Laughlin, J. D., Nwachukwu, J. C., Figuera-Losada, M., Cherry, L., Nettles, K. W., & LoGrasso, P. V. (2012) · Structure · doi:10.1016/j.str.2012.09.021 · Cited by 50 · see citing works
“…scaffold protein that interacts with the upstream activating kinases for JNK, and is required for activity in a number of different contexts, including regulation of obesity-induced insulin resistance (Jaeschke et al., 2004; Morel et al., 2010; Weston and Davis, 2007; Whitmarsh et al., 2001).”
BackgroundMorel, C., Standen, C. L., Jung, D. Y., Gray, S., Ong, H., Flavell, R. A., Kim, J. K., & Davis, R. J. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00585-10 · Cited by 30 · see citing works
Self-citation
- Authors
- Whitmarsh, A. J., Kuan, C.-Y., Kennedy, N. J., Kelkar, N., Haydar, T. F., Mordes, J. P., Appel, M., Rossini, A. A., Jones, S. N., Flavell, R. A., Rakic, P., & Davis, R. J.
- Affiliations
- Howard Hughes Medical Institute (US)
- ORCID
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2001-09-15
- Volume
- 15
- Issue
- 18
- Pages
- 2421-2432
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC312784
- OpenAlex
- W2101704246
- Cited by
- 238
- References
- 47
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 1 · 2023: 7 · 2022: 7 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 7 · 2017: 4 · 2016: 8 · 2015: 9 · 2014: 8 · 2013: 6 · 2012: 9
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (DK32520)
- National Cancer Institute (R01CA085422, CA-65861, CA85422, R01CA065861)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 32520, P30DK032520)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Keywords
- JIP1, JNK activation, c-Jun N-terminal kinase, scaffold proteins, MAPK signaling, anoxic stress, c-Jun phosphorylation, hippocampal neurons
- MeSH terms
- Animals, Carrier Proteins, Enzyme Activation, Mice, Inbred C57BL, Neurons, Apoptosis, Mice, Knockout, Oxidative Stress, Mitogen-Activated Protein Kinases, JNK Mitogen-Activated Protein Kinases, Adaptor Proteins, Signal Transducing, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
