The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Homologous Recombination Resolution Defect in Werner Syndrome
Open accessAbstract
Werner syndrome (WRN) is an uncommon autosomal recessive disease whose phenotype includes features of premature aging, genetic instability, and an elevated risk of cancer. We used three different experimental strategies to show that WRN cellular phenotypes of limited cell division potential, DNA damage hypersensitivity, and defective homologous recombination (HR) are interrelated. WRN cell survival and the generation of viable mitotic recombinant progeny could be rescued by expressing wild-type WRN protein or by expressing the bacterial resolvase protein RusA. The dependence of WRN cellular phenotypes on RAD51-dependent HR pathways was demonstrated by using a dominant-negative RAD51 protein to suppress mitotic recombination in WRN and control cells: the suppression of RAD51-dependent recombination led to significantly improved survival of WRN cells following DNA damage. These results define a physiological role for the WRN RecQ helicase protein in RAD51-dependent HR and identify a mechanistic link between defective recombination resolution and limited cell division potential, DNA damage hypersensitivity, and genetic instability in human somatic cells.
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Cites
Chromosomal stability and the DNA double-stranded break connection
van Gent, D. C., Hoeijmakers, J. H. J., & Kanaar, R. (2001) · Nature Reviews Genetics · doi:10.1038/35056049 · Cited by 1,219
The importance of repairing stalled replication forks
Cox, M. M., Goodman, M. F., Kreuzer, K. N., Sherratt, D. J., Sandler, S. J., & Marians, K. J. (2000) · Nature · doi:10.1038/35003501 · Cited by 1,044
The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling
D'Amours, D., & Jackson, S. P. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm805 · Cited by 874
Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal ageing
Goto, M. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00111-5 · Cited by 240
Cited by
DNA double-strand break repair: From mechanistic understanding to cancer treatment
HELLEDAY, T., LO, J., VANGENT, D., & ENGELWARD, B. (2007) · DNA Repair · doi:10.1016/j.dnarep.2007.02.006 · Cited by 640
The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments
Veaute, X., Jeusset, J., Soustelle, C., Kowalczykowski, S. C., Le Cam, E., & Fabre, F. (2003) · Nature · doi:10.1038/nature01585 · Cited by 621
Srs2 and Sgs1–Top3 Suppress Crossovers during Double-Strand Break Repair in Yeast
Ira, G., Malkova, A., Liberi, G., Foiani, M., & Haber, J. E. (2003) · Cell · doi:10.1016/s0092-8674(03)00886-9 · Cited by 571
Regulation and mechanisms of mammalian double-strand break repair
Valerie, K., & Povirk, L. F. (2003) · Oncogene · doi:10.1038/sj.onc.1206679 · Cited by 571
p53: traffic cop at the crossroads of DNA repair and recombination
Sengupta, S., & Harris, C. C. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1546 · Cited by 544
Metadata
- Authors
- Saintigny, Y., Makienko, K., Swanson, C., Emond, M. J., & Monnat, R. J.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2002-10-01
- Volume
- 22
- Issue
- 20
- Pages
- 6971-6978
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2168496875
- Cited by
- 258
- References
- 4
- FWCI
- 8.75
- Type
- journal article
- Language
- en
- Open access
- green
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