The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Mice Lacking the Giant Protocadherin mFAT1 Exhibit Renal Slit Junction Abnormalities and a Partially Penetrant Cyclopia and Anophthalmia Phenotype
Open accessAbstract
While roles in adhesion and morphogenesis have been documented for classical cadherins, the nonclassical cadherins are much less well understood. Here we have examined the functions of the giant protocadherin FAT by generating a transgenic mouse lacking mFAT1. These mice exhibit perinatal lethality, most probably caused by loss of the renal glomerular slit junctions and fusion of glomerular epithelial cell processes (podocytes). In addition, some mFAT1(-/-) mice show defects in forebrain development (holoprosencephaly) and failure of eye development (anophthalmia). In contrast to Drosophila, where FAT acts as a tumor suppressor gene, we found no evidence for abnormalities of proliferation in two tissues (skin and central nervous system [CNS]) containing stem and precursor cell populations and in which FAT is expressed strongly. Our results confirm a necessary role for FAT1 in the modified adhesion junctions of the renal glomerular epithelial cell and reveal hitherto unsuspected roles for FAT1 in CNS development.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Reynolds, B. A., & Weiss, S. (1992) · Science · doi:10.1126/science.1553558 · Cited by 4,482
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
Chiang, C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H., & Beachy, P. A. (1996) · Nature · doi:10.1038/383407a0 · Cited by 3,062
Kestilä, M., Lenkkeri, U., Männikkö, M., Lamerdin, J., McCready, P., Putaala, H., Ruotsalainen, V., Morita, T., Nissinen, M., Herva, R., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80057-x · Cited by 1,866
Morphogenetic roles of classic cadherins
Takeichi, M. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80102-2 · Cited by 1,450
Reynolds, B. A., & Weiss, S. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0090 · Cited by 1,360
Structural basis of cell-cell adhesion by cadherins
Shapiro, L., Fannon, A. M., Kwong, P. D., Thompson, A., Lehmann, M. S., Grübel, G., Legrand, J.-F., Als-Nielsen, J., Colman, D. R., & Hendrickson, W. A. (1995) · Nature · doi:10.1038/374327a0 · Cited by 1,156
Mutations in the human Sonic Hedgehog gene cause holoprosencephaly
Roessler, E., Belloni, E., Gaudenz, K., Jay, P., Berta, P., Scherer, S. W., Tsui, L.-C., & Muenke, M. (1996) · Nature Genetics · doi:10.1038/ng1196-357 · Cited by 1,152
A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.
Dudley, A. T., Lyons, K. M., & Robertson, E. J. (1995) · Genes & Development · doi:10.1101/gad.9.22.2795 · Cited by 1,131
Jones, P. H., & Watt, F. M. (1993) · Cell · doi:10.1016/0092-8674(93)90251-k · Cited by 1,109
Cited by
Ischemic acute renal failure: An inflammatory disease?
Bonventre, J. V., & Zuk, A. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.761_2.x · Cited by 770
Molecular evolution of the cadherin superfamily
Hulpiau, P., & van Roy, F. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.09.027 · Cited by 498
Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes
Jones, N., Blasutig, I. M., Eremina, V., Ruston, J. M., Bladt, F., Li, H., Huang, H., Larose, L., Li, S. S.-C., Takano, T., et al. (2006) · Nature · doi:10.1038/nature04662 · Cited by 489
The cadherin superfamily in neuronal connections and interactions
Takeichi, M. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2043 · Cited by 431
Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation
Morris, L. G. T., Kaufman, A. M., Gong, Y., Ramaswami, D., Walsh, L. A., Turcan, Ş., Eng, S., Kannan, K., Zou, Y., Peng, L., et al. (2013) · Nature Genetics · doi:10.1038/ng.2538 · Cited by 366
Metadata
- Authors
- Ciani, L., Patel, A., Allen, N. D., & ffrench-Constant, C.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2003-05-01
- Volume
- 23
- Issue
- 10
- Pages
- 3575-3582
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2146098038
- Cited by
- 257
- References
- 49
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Mice Lacking the Giant Protocadherin mFAT1 Exhibit Renal Slit Junction Abnormalities and a Partially Penetrant Cyclopia and Anophthalmia Phenotype. https://app.cochat.ai/papers/10.1128/mcb.23.10.3575-3582.2003
- The paper
- Ciani, L., Patel, A., Allen, N. D., & ffrench-Constant, C. (2003). Mice Lacking the Giant Protocadherin mFAT1 Exhibit Renal Slit Junction Abnormalities and a Partially Penetrant Cyclopia and Anophthalmia Phenotype. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.23.10.3575-3582.2003
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
