Cited by 407Genomics, phytochemicals, and oxidative stressHeme Oxygenase-1 and Carbon MonoxideInflammatory mediators and NSAID effects

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Transcription Factor Nrf2 Regulates Inflammation by Mediating the Effect of 15-Deoxy-Δ12,14-Prostaglandin J2

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Itoh, Ken, Mochizuki, Mie, Ishii, Yukio, Ishii, Tetsuro, Shibata, Takahiro, Kawamoto, Yoshiyuki, Kelly, Vincent, Sekizawa, Kiyohisa, Uchida, Koji, Yamamoto, Masayuki·2004·Molecular and Cellular Biology

DOI 10.1128/mcb.24.1.36-45.2004PMC PMC303336

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Abstract

Activated macrophages express high levels of Nrf2, a transcription factor that positively regulates the gene expression of antioxidant and detoxication enzymes. In this study, we examined how Nrf2 contributes to the anti-inflammatory process. As a model system of acute inflammation, we administered carrageenan to induce pleurisy and found that in Nrf2-deficient mice, tissue invasion by neutrophils persisted during inflammation and the recruitment of macrophages was delayed. Using an antibody against 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), it was observed that macrophages from pleural lavage accumulate 15d-PGJ(2). We show that in mouse peritoneal macrophages 15d-PGJ(2) can activate Nrf2 by forming adducts with Keap1, resulting in an Nrf2-dependent induction of heme oxygenase 1 and peroxiredoxin I (PrxI) gene expression. Administration of the cyclooxygenase 2 inhibitor NS-398 to mice with carrageenan-induced pleurisy caused persistence of neutrophil recruitment and, in macrophages, attenuated the 15d-PGJ(2) accumulation and PrxI expression. Administration of 15d-PGJ(2) into the pleural space of NS-398-treated wild-type mice largely counteracted both the decrease in PrxI and persistence of neutrophil recruitment. In contrast, these changes did not occur in the Nrf2-deficient mice. These results demonstrate that Nrf2 regulates the inflammation process downstream of 15d-PGJ(2) by orchestrating the recruitment of inflammatory cells and regulating the gene expression within those cells.

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VANE, J. R. (1971) · Nature New Biology · doi:10.1038/newbio231232a0 · Cited by 8,605
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Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634
Self-citation
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature · doi:10.1038/34178 · Cited by 3,525
PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
Jiang, C., Ting, A. T., & Seed, B. (1998) · Nature · doi:10.1038/34184 · Cited by 2,899
Points of control in inflammation
Nathan, C. (2002) · Nature · doi:10.1038/nature01320 · Cited by 2,738
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
Otterbein, L. E., Bach, F. H., Alam, J., Soares, M., Tao Lu, H., Wysk, M., Davis, R. J., Flavell, R. A., & Choi, A. M. K. (2000) · Nature Medicine · doi:10.1038/74680 · Cited by 2,153
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., & Talalay, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172398899 · Cited by 1,947
Self-citation
Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.
Seibert, K., Zhang, Y., Leahy, K., Hauser, S. D., Masferrer, J. L., Perkins, W., Lee, L., & Isakson, P. C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.25.12013 · Cited by 1,551
Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis
Warner, T. D., Giuliano, F., Vojnovic, I., Bukasa, A., Mitchell, J. A., & Vane, J. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7563 · Cited by 1,521

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Sharma, R., Ansari, G. S., & Awasthi, S. (2006) · Informa Healthcare eBooks · doi:10.1201/9781420004489.ch9 · Cited by 7
Physiological Substrates of Glutathione S-Transferases
Awasthi, Y. C. (2006) · CRC Press eBooks · doi:10.1201/9781420004489-12 · Cited by 7
Who Tidies Up the Lung?
Uhlig, S. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2503003 · Cited by 7
Nrf2 deficiency in muscle attenuates experimental autoimmune myositis‐induced muscle weakness
Himori, K., Yamada, M., Onoki, T., Matsumaru, D., Motohashi, H., & Okutsu, M. (2024) · The Journal of Physiology · doi:10.1113/jp286534 · Cited by 6
Nrf2 driven macrophage responses in diverse pathophysiological contexts: Disparate pieces from a shared molecular puzzle
Ganesh, G. V., Ganesan, K., Xu, B., & Ramkumar, K. M. (2022) · BioFactors · doi:10.1002/biof.1867 · Cited by 6
The NRF2 inducer CDDO-2P-Im provokes a reduction in amyloid β levels in Alzheimer’s disease model mice
Uruno, A., Kadoguchi, S., Saito, R., Koiso, S., Saigusa, D., Chu, C., Suzuki, T., Saito, T., Saido, T. C., Cuadrado, A., et al. (2024) · The Journal of Biochemistry · doi:10.1093/jb/mvae060 · Cited by 7
Self-citation
Landscape of electrophilic and inflammatory stress-mediated gene regulation in human lymphoblastoid cell lines
Ishida, N., Aoki, Y., Katsuoka, F., Nishijima, I., Nobukuni, T., Anzawa, H., Li, B., Tsuda, M., Kumada, K., Kudo, H., et al. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.09.023 · Cited by 6
Self-citation
The oxidative stress-inflammation self-perpetuating cycle in multiple sclerosis: from mechanisms to emerging antioxidant strategies
Yuan, B., Jin, X., Li, C., Shen, Y., Tian, J., & Duan, S. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1806176 · Cited by 6
“Consistent with these findings, NRF2-deficient mice exhibit exaggerated inflammatory responses in multiple inflammation models (Itoh et al., 2004; Ishii et al., 2005).”
Lactobacillus species modulates TNF-α and Nrf2 expression in carrageenan-induced rat paw oedema
Oladejo, B. O., Akingbade, G. T., Adeboboye, C. F., & Adeoye, S. B. (2024) · The Microbe · doi:10.1016/j.microb.2024.100050 · Cited by 6
15-Deoxy-Δ12,14-prostaglandin J2prevents oxidative injury by upregulating the expression of aldose reductase in vascular smooth muscle cells
Kang, E. S., Hwang, J. S., Ham, S. A., Park, M. H., Kim, G. H., Paek, K. S., Yoo, T., Lee, W. J., Kang, K. R., Lee, J. H., et al. (2013) · Free Radical Research · doi:10.3109/10715762.2013.860224 · Cited by 5
15-Deoxy-Δ12,14-prostaglandin J2Exerts Antioxidant Effects While Exacerbating Inflammation in Mice Subjected to Ureteral Obstruction
Nilsson, L. L., Palm, F., & Nørregaard, R. (2017) · Mediators of Inflammation · doi:10.1155/2017/3924912 · Cited by 5
Plasma obtained following murine hindlimb ischemic conditioning protects against oxidative stress in zebrafish models through activation of nrf2a and downregulation of duox
Guan, R., Wen, X., Leung, C. H., Ciano‐Oliveira, C. D., Lam, S., Dai, S. Y., Karbassi, F., Mauro, A., Wang, Y., & Rotstein, O. D. (2021) · PLoS ONE · doi:10.1371/journal.pone.0260442 · Cited by 5
The KEAP1-NRF2 system and neurodegenerative diseases
Uruno, A., & Yamamoto, M. P. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0005 · Cited by 8
Self-citation
Glutathione S-Transferases as Modulators of Signal Transduction
Yang, Y., & Awasthi, S. (2006) · Informa Healthcare eBooks · doi:10.1201/9781420004489.ch10 · Cited by 5
Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounterPreprint
Gioia, M. D., Poli, V., Tan, P. J., Spreafico, R., Chu, A., Cuenca, A. G., Gordts, P. L. S. M., Pandolfi, L., Meloni, F., Witztum, J. L., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.21.568047 · Cited by 5
Molecular Mechanisms of Nrf2 in Inflammation: Interactions Between Nrf2 and Inflammatory Mediators
Wang, R., & Pérez, V. (2020) · Progress in inflammation research · doi:10.1007/978-3-030-44599-7_1 · Cited by 3
Nrf2 Deficiency Exacerbates the Decline in Swallowing and Respiratory Muscle Mass and Function in Mice with Aspiration Pneumonia
Hashimoto, H., Okazaki, T., Honkura, Y., Ren, Y., Ngamsnae, P., Hisaoka, T., Koshiba, Y., Suzuki, J., Ebihara, S., & Katori, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111829 · Cited by 3
Metabolism and Roles of Eicosanoids in Brain
Farooqui, A. A. (2011) · Springer eBooks · doi:10.1007/978-1-4419-9940-5_1 · Cited by 3
Inflammation, a Key Factor in Cancer Ambush
Amjadi, O., Rafiei, A., Ajami, A., Hosseini, V., & Asgarian‐Omran, H. (2014) · Research in Molecular Medicine · doi:10.18869/acadpub.rmm.2.2.1 · Cited by 3
Apo-12'-capsorubinal exhibits anti-inflammatory effects and activates nuclear factor erythroid 2-related factor 2 in RAW264.7 macrophages.
Takatani, N., Miyafusa, H., Yamano, Y., Beppu, F., & Hosokawa, M. (2024) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2024.110125 · Cited by 2
The Role of Endothelial Glycocalyx in the Pathophysiology of Chronic Kidney Disease and Hypertension: From Molecular Mechanisms to Clinical Biomarkers
Žagar, A. M., Kolobarić, N., Šušnjara, P., Mihaljević, J., Mihaljević, Z., & Drenjancevic, I. (2026) · Life · doi:10.3390/life16040642 · Cited by 2
Cytoprotection Against Oxidative Damage by Nrf2-regulated Genes
Kwak, M., & Kensler, T. W. (2007) · Toxicological Research · doi:10.5487/tr.2007.23.3.207 · Cited by 2
Identification and Structural Analysis of New Nrf2 Activators by Mechanism‐Based Chemical Transformation of 15‐Deoxy‐Δ12, 14‐PGJ2
Kim, K., Park, J., Kim, N., Kim, S., Moon, H., An, H., Lee, J., Park, H., Surh, Y., & Suh, Y. (2016) · ChemBioChem · doi:10.1002/cbic.201600165 · Cited by 2
Nrf2 and Inflammation-Triggered Carcinogenesis
Sarkar, S., Ghosh, N., Kundu, M., & Sil, P. C. (2020) · Progress in inflammation research · doi:10.1007/978-3-030-44599-7_6 · Cited by 2
RETRACTED: The Aminopyridinol Derivative BJ-1201 Protects Murine Hippocampal Cells against Glutamate-Induced Neurotoxicity via Heme Oxygenase-1
Lee, D., Nam, T., Jeong, B., & Jeong, G. (2016) · Molecules · doi:10.3390/molecules21050594 · Cited by 2
Retracted
Somatic Genome Alterations in Human Lung Cancers
Imielinski, M. B., Hammerman, P. S., Thomas, R. K., & Meyerson, M. M. (2014) · Lung Cancer · doi:10.1002/9781118468791.ch4 · Cited by 2
Survival Strategy and Disease Pathogenesis According to the Nrf2‐Small Maf Heterodimer
Morita, M., & Motohashi, H. (2011) · doi:10.1002/9781118148143.ch5 · Cited by 2
Impact and Application of Nutraceuticals on Inflammation-Induced Colorectal Cancer Development
Liu, Y. (2017) · Springer eBooks · doi:10.1007/978-3-319-53082-6_14 · Cited by 1
Chronicity of Immune Abnormality in Atopic Dermatitis: Interacting Surface Between Environment and Immune System
Hidaka, T., Kobayashi, E. H., & Yamamoto, M. P. (2016) · Springer eBooks · doi:10.1007/978-4-431-56068-5_20 · Cited by 1
Self-citation
Nitric Oxide and Endothelial Dysfunction
Noiri, E., & Minami, K. (2014) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4939-0679-6_4
Hormetic dietary phytochemicals from Western Canadian plants: Identification, characterization and mechanistic insights
Konkin, D. J. F. (2013) · University Library - University of Saskatchewan (University of Saskatchewan)
Multidrug resistant protein-three gene regulation
Mahaffey, C. M. (2010) · eScholarship (California Digital Library)
in mesangial cells: role in the inhibition of pro-inflammatory genes*
Sánchez-Gómez, F. J., Cernuda‐Morollón, E., Stamatakis, K., & Pérez‐Sala, D. (2004)
Molecular and pharmacological study of transcription factor Nrf2
Lin, W. (2009) · Rutgers University Community Repository (Rutgers University) · doi:10.7282/t34x5819
Inhibition of lung tumorigenesis and cancer cell growth by EGCG and other chemopreventive agents
Jin, H. (2013) · doi:10.7282/t3w9576r
“Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a transcription factor that plays a key role in the transcriptional regulation of antioxidant and detoxification genes to inhibit inflammation and protect against oxidative stress [240-242, 277].”
Background
Ginsenoside Rg1 alleviates H2O2-induced oxidative stress and apoptosis in bovine mammary epithelial cells through the NFE2L2 signaling pathwayPreprint
Qian, W., Chang, R., Jia, H., Fu, S., & Sun, X. (2022) · Research Square · doi:10.21203/rs.3.rs-1450309/v1
5-Deazaflavin (TND1128) and its hybrid analogs are cytoprotective against hydrogen peroxide (H 2 O 2 )-induced oxidative stressPreprint
Kubota, K., Katsurabayashi, S., Watanabe, T., Iwasaki, K., Nagamatsu, T., & Akaike, N. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.07.592882
Modulation of the KEAP1–NRF2 Pathway for the Treatment of Neurodegenerative Diseases: Rationale, Assay Methodologies, and Reference Compounds
Clerigué, J., Pascual-Guerra, J., Leon, R. M., & Menéndez, J. C. (2024) · Neuromethods · doi:10.1007/978-1-0716-4232-0_5
Additional file 3 of A gene co-association network regulating gut microbial communities in a Duroc pig population
Reverter, A., Ballester, M., Alexandre, P. A., Mármol‐Sánchez, E., Dalmau, A., Quintanilla, R., & Ramayo‐Caldas, Y. (2021) · Figshare · doi:10.6084/m9.figshare.14072260
Additional file 1 of Metabolomic and transcriptomic profiling of adult mice and larval zebrafish leptin mutants reveal a common pattern of changes in metabolites and signaling pathways
Ding, Y., Haks, M. C., Forn‐Cuní, G., He, J., Nowik, N., Harms, A. C., Hankemeier, T., Eeza, M. N. H., Matysik, J., Alia, A., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14926867

Authors: Itoh, K., Mochizuki, M., Ishii, Y., Ishii, T., Shibata, T., Kawamoto, Y., Kelly, V., Sekizawa, K., Uchida, K., & Yamamoto, M.
Affiliations: Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA) (JP)
Institute of Clinical Medicines
University of Tsukuba (JP)
Nagoya University (JP)
Institute of Social Medicines, University of Tsukuba, Tsukuba 305-8577
Corresponding author: Yamamoto, Masayuki
ORCID: Itoh, Ken
Ishii, Yukio
Shibata, Takahiro
Kawamoto, Yoshiyuki
Kelly, Vincent
Yamamoto, Masayuki
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 2004-01-01
Volume: 24
Issue: 1
Pages: 36-45
ISSN: 0270-7306 (ISSN-L)
1098-5549
DOI: 10.1128/mcb.24.1.36-45.2004
PMC: PMC303336
OpenAlex: W2113971187
Cited by: 407
References: 46
Citations by year: 2026: 4 · 2025: 8 · 2024: 9 · 2023: 13 · 2022: 13 · 2021: 21 · 2020: 20 · 2019: 20 · 2018: 21 · 2017: 21 · 2016: 24 · 2015: 23 · 2014: 14 · 2013: 21 · 2012: 11
FWCI: 6.55
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Molecular and Cellular Biology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Keywords: Nrf2, 15-deoxy-Δ12,14-prostaglandin J2, anti-inflammatory signaling, macrophages, neutrophil recruitment, carrageenan-induced pleurisy, Keap1, heme oxygenase-1, peroxiredoxin 1, cyclooxygenase-2, NS-398, acute inflammation, Nrf2-deficient mice
MeSH terms: Animals, DNA-Binding Proteins, Inflammation, Isoenzymes, Macrophages, Peritoneum, Pleurisy, Prostaglandin-Endoperoxide Synthases, Prostaglandin D2, Trans-Activators, Hepatocytes, NF-E2-Related Factor 2, Mice, Cyclooxygenase 2

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Transcription Factor Nrf2 Regulates Inflammation by Mediating the Effect of 15-Deoxy-Δ12,14-Prostaglandin J2

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