The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Inactivation of Stat5 in Mouse Mammary Epithelium during Pregnancy Reveals Distinct Functions in Cell Proliferation, Survival, and Differentiation
Open accessAbstract
This study explored the functions of the signal transducers and activators of transcription 5a and 5b (referred to as Stat5 here) during different stages of mouse mammary gland development by using conditional gene inactivation. Mammary gland morphogenesis includes cell specification, proliferation and differentiation during pregnancy, cell survival and maintenance of differentiation throughout lactation, and cell death during involution. Stat5 is activated by prolactin, and its presence is mandatory for the proliferation and differentiation of mammary epithelium during pregnancy. To address the question of whether Stat5 is also necessary for the maintenance and survival of the differentiated epithelium, the two genes were deleted at different time points. The 110-kb Stat5 locus in the mouse was bracketed with loxP sites, and its deletion was accomplished by using two Cre-expressing transgenic lines. Loss of Stat5 prior to pregnancy prevented epithelial proliferation and differentiation. Deletion of Stat5 during pregnancy, after mammary epithelium had entered Stat5-mediated differentiation, resulted in premature cell death, indicating that at this stage epithelial cell proliferation, differentiation, and survival require Stat5.
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Citations
Cites
STATs: transcriptional control and biological impact
Levy, D. E., & Darnell, J. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm909 · Cited by 3,201
Mammary gland involution is delayed by activated Akt in transgenic mice
Schwertfeger, K. L., Richert, M. M., & Anderson, S. M. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.6.0663 · Cited by 169
Cited by
Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation
Laurence, A., Tato, C. M., Davidson, T. S., Kanno, Y., Chen, Z., Yao, Z., Blank, R. B., Meylan, F., Siegel, R., Hennighausen, L., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.02.009 · Cited by 1,507
Self-citationMacias, H., & Hinck, L. (2012) · WIREs Developmental Biology · doi:10.1002/wdev.35 · Cited by 849
Burchill, M. A., Yang, J., Vogtenhuber, C., Blazar, B. R., & Farrar, M. A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.1.280 · Cited by 834
Biology and significance of the JAK/STAT signalling pathways
Kiu, H., & Nicholson, S. E. (2012) · Growth Factors · doi:10.3109/08977194.2012.660936 · Cited by 470
IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
Guo, L., Wei, G., Zhu, J., Liao, W., Leonard, W. J., Zhao, K., & Paul, W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906988106 · Cited by 417
Metadata
- Authors
- Cui, Y., Riedlinger, G., Miyoshi, K., Tang, W., Li, C., Deng, C.-X., Robinson, G. W., & Hennighausen, L.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2004-09-01
- Volume
- 24
- Issue
- 18
- Pages
- 8037-8047
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2117468155
- Cited by
- 497
- References
- 2
- FWCI
- 11.46
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Inactivation of Stat5 in Mouse Mammary Epithelium during Pregnancy Reveals Distinct Functions in Cell Proliferation, Survival, and Differentiation. https://app.cochat.ai/papers/10.1128/mcb.24.18.8037-8047.2004
- The paper
- Cui, Y., Riedlinger, G., Miyoshi, K., Tang, W., Li, C., Deng, C.-X., Robinson, G. W., & Hennighausen, L. (2004). Inactivation of Stat5 in Mouse Mammary Epithelium during Pregnancy Reveals Distinct Functions in Cell Proliferation, Survival, and Differentiation. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.24.18.8037-8047.2004
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