The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells
Open accessAbstract
IL-2 −/− mice develop autoimmunity despite having relatively normal numbers of regulatory T cells (Tregs). In contrast, we demonstrate that IL-2−/− × IL-15−/− and IL-2Rβ−/− mice have a significant decrease in Treg numbers. Ectopic expression of foxp3 in a subset of CD4+ T cells rescued Treg development and prevented autoimmunity in IL-2Rβ−/− mice, suggesting that IL-2Rβ-dependent signals regulate foxp3 expression in Tregs. Subsequent analysis of IL-2Rβ-dependent signal transduction pathways established that the transcription factor STAT5 is necessary and sufficient for Treg development. Specifically, T cell-specific deletion of STAT5 prevented Treg development; conversely, reconstitution of IL-2Rβ−/− mice with bone marrow cells expressing an IL-2Rβ mutant that exclusively activates STAT5 restored Treg development. Finally, STAT5 binds to the promoter of the foxp3 gene suggesting that IL-2Rβ-dependent STAT5 activation promotes Treg differentiation by regulating expression of foxp3.
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Cites
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Cited by
Differentiation of Effector CD4 T Cell Populations
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Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor
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CD4 + T Cells: Differentiation and Functions
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Metadata
- Authors
- Burchill, M. A., Yang, J., Vogtenhuber, C., Blazar, B. R., & Farrar, M. A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-01-01
- Volume
- 178
- Issue
- 1
- Pages
- 280-290
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1878828051
- Cited by
- 834
- References
- 38
- FWCI
- 18.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells. https://app.cochat.ai/papers/10.4049/jimmunol.178.1.280
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- Burchill, M. A., Yang, J., Vogtenhuber, C., Blazar, B. R., & Farrar, M. A. (2007). IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.178.1.280
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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