The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Tenomodulin Is Necessary for Tenocyte Proliferation and Tendon Maturation
Open accessAbstract
Tenomodulin (Tnmd) is a member of a new family of type II transmembrane glycoproteins. It is predominantly expressed in tendons, ligaments, and eyes, whereas the only other family member, chondromodulin I (ChM-I), is highly expressed in cartilage and at lower levels in the eye and thymus. The C-terminal extracellular domains of both proteins were shown to modulate endothelial-cell proliferation and tube formation in vitro and in vivo. We analyzed Tnmd function in vivo and provide evidence that Tnmd is processed in vivo and that the proteolytically cleaved C-terminal domain can be found in tendon extracts. Loss of Tnmd expression in gene targeted mice abated tenocyte proliferation and led to a reduced tenocyte density. The deposited amounts of extracellular matrix proteins, including collagen types I, II, III, and VI and decorin, lumican, aggrecan, and matrilin-2, were not affected, but the calibers of collagen fibrils varied significantly and exhibited increased maximal diameters. Tnmd-deficient mice did not have changes in tendon vessel density, and mice lacking both Tnmd and ChM-I had normal retinal vascularization and neovascularization after oxygen-induced retinopathy. These results suggest that Tnmd is a regulator of tenocyte proliferation and is involved in collagen fibril maturation but do not confirm an in vivo involvement of Tnmd in angiogenesis.
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Oxygen-induced retinopathy in the mouse.
Smith, L. E. H., Wesolowski, E., McLellan, A., Kostyk, S. K., D’Amato, R. J., Sullivan, R., & D'Amore, P. A. (1994) · PubMed · Cited by 1,627
Alon, T., Hemo, I., Itin, A., Pe'er, J., Stone, J., & Keshet, E. (1995) · Nature Medicine · doi:10.1038/nm1095-1024 · Cited by 1,604
Role of Extracellular Matrix in Adaptation of Tendon and Skeletal Muscle to Mechanical Loading
KJÆR, M. (2004) · Physiological Reviews · doi:10.1152/physrev.00031.2003 · Cited by 1,586
Targeted Disruption of Decorin Leads to Abnormal Collagen Fibril Morphology and Skin Fragility
Danielson, K. G., Baribault, H., Holmes, D. F., Graham, H., Kadler, K. E., & Iozzo, R. V. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.3.729 · Cited by 1,406
Mammalian subtilisins: The long-sought dibasic processing endoproteases
Barr, P. J. (1991) · Cell · doi:10.1016/0092-8674(91)90129-m · Cited by 743
Chakravarti, S., Magnuson, T., Lass, J. H., Jepsen, K. J., LaMantia, C., & Carroll, H. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.5.1277 · Cited by 731
Cheresh, D. A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.18.6471 · Cited by 561
Kyriakides, T. R., Zhu, Y.-H., Smith, L. T., Bain, S. D., Yang, Z., Lin, M. T., Danielson, K. G., Iozzo, R. V., LaMarca, M., McKinney, C. E., et al. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.2.419 · Cited by 503
Corsi, A., Xu, T., Chen, X.-D., Boyde, A., Liang, J., Mankani, M., Sommer, B., Iozzo, R. V., Eichstetter, I., Robey, P. G., et al. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.7.1180 · Cited by 465
Svensson, L., Aszódi, A., Reinholt, F. P., Fässler, R., Heinegård, D., & Oldberg, Å. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.14.9636 · Cited by 444
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Havis, E., & Duprez, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051664 · Cited by 494
Tendon and ligament regeneration and repair: Clinical relevance and developmental paradigm
Yang, G., Rothrauff, B. B., & Tuan, R. S. (2013) · Birth Defects Research Part C: Embryo Today: Reviews · doi:10.1002/bdrc.21041 · Cited by 469
De Micheli, A. J., Laurilliard, E. J., Heinke, C. L., Ravichandran, H., Fraczek, P., Soueid-Baumgarten, S., De Vlaminck, I., Elemento, O., & Cosgrove, B. D. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.067 · Cited by 373
Conversion of Mechanical Force into TGF-β-Mediated Biochemical Signals
Maeda, T., Sakabe, T., Sunaga, A., Sakai, K., Rivera, A. L., Keene, D. R., Sasaki, T., Stavnezer, E., Iannotti, J., Schweitzer, R., et al. (2011) · Current Biology · doi:10.1016/j.cub.2011.04.007 · Cited by 366
The Mohawk homeobox gene is a critical regulator of tendon differentiation
Ito, Y., Toriuchi, N., Yoshitaka, T., Ueno-Kudoh, H., Sato, T., Yokoyama, S., Nishida, K., Akimoto, T., Takahashi, M., Miyaki, S., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000525107 · Cited by 324
Metadata
- Authors
- Docheva, D., Hunziker, E. B., Fässler, R., & Brandau, O.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2005-01-01
- Volume
- 25
- Issue
- 2
- Pages
- 699-705
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2105611128
- Cited by
- 425
- References
- 36
- FWCI
- 6.15
- Type
- journal article
- Language
- en
- Open access
- green
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- Docheva, D., Hunziker, E. B., Fässler, R., & Brandau, O. (2005). Tenomodulin Is Necessary for Tenocyte Proliferation and Tendon Maturation. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.25.2.699-705.2005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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