The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Silencing of Unpaired Chromatin and Histone H2A Ubiquitination in Mammalian Meiosis
Open accessAbstract
During meiotic prophase in male mammals, the X and Y chromosomes are incorporated in the XY body. This heterochromatic body is transcriptionally silenced and marked by increased ubiquitination of histone H2A. This led us to investigate the relationship between histone H2A ubiquitination and chromatin silencing in more detail. First, we found that ubiquitinated H2A also marks the silenced X chromosome of the Barr body in female somatic cells. Next, we studied a possible relationship between H2A ubiquitination, chromatin silencing, and unpaired chromatin in meiotic prophase. The mouse models used carry an unpaired autosomal region in male meiosis or unpaired X and Y chromosomes in female meiosis. We show that ubiquitinated histone H2A is associated with transcriptional silencing of large chromatin regions. This silencing in mammalian meiotic prophase cells concerns unpaired chromatin regions and resembles a phenomenon described for the fungus Neurospora crassa and named meiotic silencing by unpaired DNA.
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Cites
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Role of Histone H3 Lysine 27 Methylation in X Inactivation
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Partitioning and Plasticity of Repressive Histone Methylation States in Mammalian Chromatin
Peters, A. H. F. M., Kubicek, S., Mechtler, K., O'Sullivan, R. J., Derijck, A. A. H. A., Perez-Burgos, L., Kohlmaier, A., Opravil, S., Tachibana, M., Shinkai, Y., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00477-5 · Cited by 1,152
Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast
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Recombinational DNA double-strand breaks in mice precede synapsis
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Self-citationEpigenetic Dynamics of Imprinted X Inactivation During Early Mouse Development
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Proteasomes and their kin: proteases in the machine age
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Cited by
A histone H3 methyltransferase controls epigenetic events required for meiotic prophase
Hayashi, K., Yoshida, K., & Matsui, Y. (2005) · Nature · doi:10.1038/nature04112 · Cited by 472
A dynamic ubiquitin equilibrium couples proteasomal activity to chromatin remodeling
Dantuma, N. P., Groothuis, T. A. M., Salomons, F. A., & Neefjes, J. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200510071 · Cited by 265
The sperm epigenome and potential implications for the developing embryo
Jenkins, T. G., & Carrell, D. T. (2012) · Reproduction · doi:10.1530/rep-11-0450 · Cited by 232
Marteijn, J. A., Bekker-Jensen, S., Mailand, N., Lans, H., Schwertman, P., Gourdin, A. M., Dantuma, N. P., Lukas, J., & Vermeulen, W. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200902150 · Cited by 184
Metadata
- Authors
- Baarends, W. M., Wassenaar, E., van der Laan, R., Hoogerbrugge, J., Sleddens-Linkels, E., Hoeijmakers, J. H. J., de Boer, P., & Grootegoed, J. A.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2005-02
- Volume
- 25
- Issue
- 3
- Pages
- 1041-1053
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2097727084
- Cited by
- 300
- References
- 45
- FWCI
- 7.49
- Type
- journal article
- Language
- en
- Open access
- green
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- Baarends, W. M., Wassenaar, E., van der Laan, R., Hoogerbrugge, J., Sleddens-Linkels, E., Hoeijmakers, J. H. J., de Boer, P., & Grootegoed, J. A. (2005). Silencing of Unpaired Chromatin and Histone H2A Ubiquitination in Mammalian Meiosis. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.25.3.1041-1053.2005
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