The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Insulin Hypersensitivity and Resistance to Streptozotocin-Induced Diabetes in Mice Lacking PTEN in Adipose Tissue
Open accessAbstract
In adipose tissue, insulin controls glucose and lipid metabolism through the intracellular mediators phosphatidylinositol 3-kinase and serine-threonine kinase AKT. Phosphatase and a tensin homolog deleted from chromosome 10 (PTEN), a negative regulator of the phosphatidylinositol 3-kinase/AKT pathway, is hypothesized to inhibit the metabolic effects of insulin. Here we report the generation of mice lacking PTEN in adipose tissue. Loss of Pten results in improved systemic glucose tolerance and insulin sensitivity, associated with decreased fasting insulin levels, increased recruitment of the glucose transporter isoform 4 to the cell surface in adipose tissue, and decreased serum resistin levels. Mutant animals also exhibit increased insulin signaling and AMP kinase activity in the liver. Pten mutant mice are resistant to developing streptozotocin-induced diabetes. Adipose-specific Pten deletion, however, does not alter adiposity or plasma fatty acids. Our results demonstrate that in vivo PTEN is a potent negative regulator of insulin signaling and insulin sensitivity in adipose tissue. Furthermore, PTEN may be a promising target for nutritional and/or pharmacological interventions aimed at reversing insulin resistance.
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Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
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Self-citationWang, S., Gao, J., Lei, Q., Rozengurt, N., Pritchard, C., Jiao, J., Thomas, G. V., Li, G., Roy-Burman, P., Nelson, P. S., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00215-0 · Cited by 1,109
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Cited by
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
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Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training
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Biochemical and cellular properties of insulin receptor signalling
Haeusler, R. A., McGraw, T. E., & Accili, D. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.89 · Cited by 739
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Metadata
- Authors
- Kurlawalla-Martinez, C., Stiles, B., Wang, Y., Devaskar, S. U., Kahn, B. B., & Wu, H.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2005-03-01
- Volume
- 25
- Issue
- 6
- Pages
- 2498-2510
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2132924550
- Cited by
- 191
- References
- 8
- FWCI
- 10.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Kurlawalla-Martinez, C., Stiles, B., Wang, Y., Devaskar, S. U., Kahn, B. B., & Wu, H. (2005). Insulin Hypersensitivity and Resistance to Streptozotocin-Induced Diabetes in Mice Lacking PTEN in Adipose Tissue. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.25.6.2498-2510.2005
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