The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Regulation, linkage, and sequence of mouse metallothionein I and II genes.
Open accessAbstract
The mouse metallothionein II (MT-II) gene is located approximately 6 kilobases upstream of the MT-I gene. A comparison of the sequences of mouse MT-I and MT-II genes (as well as those of other mammals) reveals that the coding regions are highly conserved even at "silent" positions but that the noncoding regions and introns are extremely divergent between primates and rodents. There are four blocks of conserved sequences in the promoters of mouse MT-I, mouse MT-II, and human MT-IIA genes; one includes the TATAAA sequence, and another has been implicated in regulation by heavy metals. Mouse MT-I and MT-II mRNAs are induced to approximately the same extent in vivo in response to cadmium, dexamethasone, or lipopolysaccharide. Mouse MT-I and MT-II genes are regulated by metals but not by glucocorticoids after transfection into HeLa cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
DNA sequencing with chain-terminating inhibitors
Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572
[57] Sequencing end-labeled DNA with base-specific chemical cleavages
Maxam, A. M., & Gilbert, W. (1980) · Methods in Enzymology · doi:10.1016/s0076-6879(80)65059-9 · Cited by 14,315
Organization and Expression of Eucaryotic Split Genes Coding for Proteins
Breathnach, R., & Chambon, P. (1981) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.50.070181.002025 · Cited by 4,548
Southern, P. J., & Berg, P. R. (1982) · PubMed · Cited by 2,740
McKnight, G. S., & Palmiter, R. D. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86807-2 · Cited by 929
Self-citationKarin, M., Haslinger, A., Holtgreve, H., Richards, R. I., Krauter, P., Westphal, H. M., & Beato, M. (1984) · Nature · doi:10.1038/308513a0 · Cited by 907
Hamada, H., Petrino, M. G., & Kakunaga, T. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.21.6465 · Cited by 743
Transcriptional regulation of the mouse metallothionein-I gene by heavy metals.
Durnam, D. M., & Palmiter, R. D. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69264-1 · Cited by 585
Self-citationArnott, S., Chandrasekaran, R., Birdsall, D. L., Leslie, A. G. W., & Ratliff, R. L. (1980) · Nature · doi:10.1038/283743a0 · Cited by 518
DNA methylation controls the inducibility of the mouse metallothionein-I gene in lymphoid cells
Compere, S. J., & Palmiter, R. D. (1981) · Cell · doi:10.1016/0092-8674(81)90248-8 · Cited by 465
Self-citation
Cited by
Metallothionein: the multipurpose protein
Coyle, P., Philcox, J. C., Carey, L. C., & Rofe, A. M. (2002) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s00018-002-8454-2 · Cited by 1,304
Gu, W., Schneider, J. W., Condorelli, G., Kaushal, S., Mahdavi, V., & Nadal-Ginard, B. (1993) · Cell · doi:10.1016/0092-8674(93)90110-c · Cited by 729
Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium.
Masters, B. A., Kelly, E. J., Quaife, C. J., Brinster, R. L., & Palmiter, R. D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.584 · Cited by 621
Self-citationMT-III, a brain-specific member of the metallothionein gene family.
Palmiter, R. D., Findley, S. D., Whitmore, T. E., & Durnam, D. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.14.6333 · Cited by 559
Self-citationHeuchel, R., Radtke, F., Georgiev, O., Stark, G., Aguet, M., & Schaffner, W. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06581.x · Cited by 493
Metadata
- Authors
- Searle, P. F., Davison, B. L., Stuart, G. W., Wilkie, T. M., Norstedt, G., & Palmiter, R. D.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1984-07
- Volume
- 4
- Issue
- 7
- Pages
- 1221-1230
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2143609309
- Cited by
- 344
- References
- 33
- FWCI
- 25.31
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Regulation, linkage, and sequence of mouse metallothionein I and II genes. https://app.cochat.ai/papers/10.1128/mcb.4.7.1221
- The paper
- Searle, P. F., Davison, B. L., Stuart, G. W., Wilkie, T. M., Norstedt, G., & Palmiter, R. D. (1984). Regulation, linkage, and sequence of mouse metallothionein I and II genes. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.4.7.1221
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
