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A single domain of yeast poly(A)-binding protein is necessary and sufficient for RNA binding and cell viability.
Open accessAbstract
The poly(A)-binding protein (PAB) gene of Saccharomyces cerevisiae is essential for cell growth. A 66-amino acid polypeptide containing half of a repeated N-terminal domain can replace the entire protein in vivo. Neither an octapeptide sequence conserved among eucaryotic RNA-binding proteins nor the C-terminal domain of PAB is required for function in vivo. A single N-terminal domain is nearly identical to the entire protein in the number of high-affinity sites for poly(A) binding in vitro (one site with an association constant of approximately 2 X 10(7) M-1) and in the size of the binding site (12 A residues). Multiple N-terminal domains afford a mechanism of PAB transfer between poly(A) strands.
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Citations
Cited by
eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation
Gingras, A.-C., Raught, B., & Sonenberg, N. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.913 · Cited by 2,121
mRNA stability in mammalian cells
Ross, J. (1995) · Microbiological Reviews · doi:10.1128/mr.59.3.423-450.1995 · Cited by 1,411
The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency.
Gallie, D. R. (1991) · Genes & Development · doi:10.1101/gad.5.11.2108 · Cited by 868
Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G.
Tarun, S. Z., & Sachs, A. B. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01108.x · Cited by 688
Self-citationDo the poly(A) tail and 3’ untranslated region control mRNA translation?
Jackson, R. J., & Standart, N. (1990) · Cell · doi:10.1016/0092-8674(90)90235-7 · Cited by 590
Metadata
- Authors
- Sachs, A. B., Davis, R. W., & Kornberg, R. D.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1987-09
- Volume
- 7
- Issue
- 9
- Pages
- 3268-3276
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W1936434484
- Cited by
- 423
- References
- 0
- FWCI
- 5.15
- Type
- journal article
- Language
- en
- Open access
- green
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- Sachs, A. B., Davis, R. W., & Kornberg, R. D. (1987). A single domain of yeast poly(A)-binding protein is necessary and sufficient for RNA binding and cell viability. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.7.9.3268
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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