The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
The Staphylococcal Biofilm: Adhesins, Regulation, and Host Response
Open accessAbstract
The staphylococci comprise a diverse genus of Gram-positive, nonmotile commensal organisms that inhabit the skin and mucous membranes of humans and other mammals. In general, staphylococci are benign members of the natural flora, but many species have the capacity to be opportunistic pathogens, mainly infecting individuals who have medical device implants or are otherwise immunocompromised.Staphylococcus aureus and Staphylococcus epidermidis are major sources of hospital-acquired infections and are the most common causes of surgical site infections and medical device-associated bloodstream infections. The ability of staphylococci to form biofilms in vivo makes them highly resistant to chemotherapeutics and leads to chronic diseases. These biofilm infections include osteomyelitis, endocarditis, medical device infections, and persistence in the cystic fibrosis lung. Here, we provide a comprehensive analysis of our current understanding of staphylococcal biofilm formation, with an emphasis on adhesins and regulation, while also addressing how staphylococcal biofilms interact with the immune system. On the whole, this review will provide a thorough picture of biofilm formation of the staphylococcus genus and how this mode of growth impacts the host.
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Cites
1 retracted
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Neutrophil Extracellular Traps Kill Bacteria
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BackgroundMSCRAMM-MEDIATED ADHERENCE OF MICROORGANISMS TO HOST TISSUES
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Cited by
Sharma, S., Mohler, J., Mahajan, S. D., Schwartz, S. A., Bruggemann, L., & Aalinkeel, R. (2023) · Microorganisms · doi:10.3390/microorganisms11061614 · Cited by 993
Microbial functional amyloids serve diverse purposes for structure, adhesion and defence
Shanmugam, N., Baker, M. O. D. G., Ball, S. R., Steain, M., Pham, C. L. L., & Sunde, M. (2019) · Biophysical Reviews · doi:10.1007/s12551-019-00526-1 · Cited by 75
Metadata
- Authors
- Paharik, A. E., & Horswill, A. R.
- Venue
- Microbiology Spectrum
- Publisher
- American Society for Microbiology
- Published
- 2016-03-25
- Volume
- 4
- Issue
- 2
- ISSN
- 2165-0497 (ISSN-L)
- OpenAlex
- W2313619242
- Cited by
- 471
- References
- 27
- FWCI
- 15.35
- Type
- journal article
- Language
- en
- Open access
- green
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- Paharik, A. E., & Horswill, A. R. (2016). The Staphylococcal Biofilm: Adhesins, Regulation, and Host Response. Microbiology Spectrum. https://doi.org/10.1128/microbiolspec.vmbf-0022-2015
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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