The DOI matches its Crossref record; 75 of the 76 references it cites were found in a registry or an index.
Microbial NAD Metabolism: Lessons from Comparative Genomics
Open accessAbstract
SUMMARY: NAD is a coenzyme for redox reactions and a substrate of NAD-consuming enzymes, including ADP-ribose transferases, Sir2-related protein lysine deacetylases, and bacterial DNA ligases. Microorganisms that synthesize NAD from as few as one to as many as five of the six identified biosynthetic precursors have been identified. De novo NAD synthesis from aspartate or tryptophan is neither universal nor strictly aerobic. Salvage NAD synthesis from nicotinamide, nicotinic acid, nicotinamide riboside, and nicotinic acid riboside occurs via modules of different genes. Nicotinamide salvage genes nadV and pncA , found in distinct bacteria, appear to have spread throughout the tree of life via horizontal gene transfer. Biochemical, genetic, and genomic analyses have advanced to the point at which the precursors and pathways utilized by a microorganism can be predicted. Challenges remain in dissecting regulation of pathways.
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“However, mammals do not have a homologous enzyme (12, 25–28).”
From Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD + synthesis via enterohepatic circulation (2025) · cites this paper as [25]
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“Most bacteria have a NAM deamidase, an enzyme that converts NAM into NA.”
From Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD + synthesis via enterohepatic circulation (2025) · cites this paper as [25]
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Nicotinamide riboside is uniquely and orally bioavailable in mice and humans
Trammell, S. A. J., Schmidt, M. S., Weidemann, B. J., Redpath, P., Jaksch, F., Dellinger, R. W., Li, Z., Abel, E. D., Migaud, M. E., & Brenner, C. (2016) · Nature Communications · doi:10.1038/ncomms12948 · Cited by 697
Self-citationMetabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity
Yoshii, K., Hosomi, K., Sawane, K., & Kunisawa, J. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00048 · Cited by 607
It takes two to tango: NAD(+) and sirtuins in aging/longevity control
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NADPH-generating systems in bacteria and archaea
Spaans, S. K., Weusthuis, R. A., John van der, O. O. S. T., & Kengen, S. W. M. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00742 · Cited by 389
Metadata
- Authors
- Gazzaniga, F., Stebbins, R., Chang, S. Z., McPeek, M. A., & Brenner, C.
- Affiliations
- Dartmouth College (US)
- University of Iowa (US)
- Venue
- Microbiology and Molecular Biology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2009-09
- Volume
- 73
- Issue
- 3
- Pages
- 529-541
- ISSN
- 1092-2172 (ISSN-L)
- 1098-5557
- PMC
- PMC2738131
- OpenAlex
- W2055192452
- Cited by
- 230
- References
- 76
- Citations by year
- 2026: 17 · 2025: 17 · 2024: 19 · 2023: 18 · 2022: 25 · 2021: 14 · 2020: 21 · 2019: 15 · 2018: 16 · 2017: 7 · 2016: 15 · 2015: 5 · 2014: 13 · 2013: 5 · 2012: 6
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Microbiology and Molecular Biology Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Dartmouth College
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- NAD+ metabolism, NAD biosynthesis, nicotinamide riboside, horizontal gene transfer, pncA, comparative genomics
- MeSH terms
- Bacteria, NAD, Genome, Bacterial, Sequence Homology, Amino Acid, Evolution, Molecular, Gene Transfer, Horizontal, Genomics, Biosynthetic Pathways
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