It takes two to tango: NAD(+) and sirtuins in aging/longevity control

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

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Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

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Requirement of NAD and <i>SIR2</i> for Life-Span Extension by Calorie Restriction in <i>Saccharomyces cerevisiae</i>

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NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

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Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

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NAD+ and sirtuins in aging and disease

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Sir2 mediates longevity in the fly through a pathway related to calorie restriction

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Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

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The growing landscape of lysine acetylation links metabolism and cell signalling

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Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

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NAD ⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

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The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

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Circadian Control of the NAD ⁺ Salvage Pathway by CLOCK-SIRT1

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Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD ⁺ Biosynthesis

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The sirtuin SIRT6 regulates lifespan in male mice

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Mitonuclear protein imbalance as a conserved longevity mechanism

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The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells

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Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1

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Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival

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PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

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Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

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Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

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SIRT5 deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle

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Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

Anderson, R. M., Bitterman, K. J., Wood, J. G., Medvedik, O., & Sinclair, D. A. (2003) · Nature · doi:10.1038/nature01578 · Cited by 736 · see citing works

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

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Circadian Clock NAD + Cycle Drives Mitochondrial Oxidative Metabolism in Mice

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Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

Feldman, J. L., Baeza, J., & Denu, J. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.c113.511261 · Cited by 637 · cited 1× · see citing works

Calorie restriction extends yeast life span by lowering the level of NADH

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Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

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SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

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Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

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Interventions to slow aging in humans: are we ready?

Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown‐Borg, H. M., Caruso, C., Curiel, T. J., Cabo, R., Franceschi, C., Gems, D., et al. (2015) · Aging Cell · doi:10.1111/acel.12338 · Cited by 592 · see citing works

Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+

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Nampt: linking NAD biology, metabolism and cancer

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Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38

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Nonenzymatic Protein Acylation as a Carbon Stress Regulated by Sirtuin Deacylases

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Skeletal muscle NAMPT is induced by exercise in humans

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Partitioning Circadian Transcription by SIRT6 Leads to Segregated Control of Cellular Metabolism

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Nicotinamide Phosphoribosyltransferase Regulates Cell Survival Through NAD + Synthesis in Cardiac Myocytes

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SirT3 Regulates the Mitochondrial Unfolded Protein Response

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Sirtuins: guardians of mammalian healthspan

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Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging

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The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet‐induced obesity

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Sirtuin catalysis and regulation

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SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice

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Complete Genome Sequence of the Broad-Host-Range Vibriophage KVP40: Comparative Genomics of a T4-Related Bacteriophage

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Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

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Nicotinamide Phosphoribosyltransferase (Nampt): A Link Between NAD Biology, Metabolism, and Diseases

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The importance of NAMPT / NAD / SIRT1 in the systemic regulation of metabolism and ageing

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Microbial NAD Metabolism: Lessons from Comparative Genomics

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The NAD World: A New Systemic Regulatory Network for Metabolism and Aging—Sirt1, Systemic NAD Biosynthesis, and Their Importance

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Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake

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Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes

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Kinetic and Structural Basis for Acyl-Group Selectivity and NAD+ Dependence in Sirtuin-Catalyzed Deacylation

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Life Span Extension and Neuronal Cell Protection by Drosophila Nicotinamidase

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Obesity Is Associated With Low NAD+/SIRT Pathway Expression in Adipose Tissue of BMI-Discordant Monozygotic Twins

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Coenzyme Specificity of Sir2 Protein Deacetylases

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“Clocks” in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging

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Relative importance of redox buffers GSH and NAD (P)H in age‐related neurodegeneration and Alzheimer disease‐like mouse neurons

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The Evolutionarily Conserved Longevity Determinants HCF-1 and SIR-2.1/SIRT1 Collaborate to Regulate DAF-16/FOXO

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dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner

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Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH

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Dissecting systemic control of metabolism and aging in the NAD World: The importance of SIRT1 and NAMPT‐mediated NAD biosynthesis

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Intracellular Nicotinamide Phosphoribosyltransferase Protects against Hepatocyte Apoptosis and Is Down-Regulated in Nonalcoholic Fatty Liver Disease

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Dietary restriction involves NAD +‐dependent mechanisms and a shift toward oxidative metabolism

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Nicotinamide Phosphoribosyltransferase Is Required for the Calorie Restriction-Mediated Improvements in Oxidative Stress, Mitochondrial Biogenesis, and Metabolic Adaptation

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Assimilation of Endogenous Nicotinamide Riboside Is Essential for Calorie Restriction-mediated Life Span Extension in Saccharomyces cerevisiae

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Natural genetic variation in yeast longevityPreprint

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Identification of Isn1 and Sdt1 as Glucose- and Vitamin-regulated Nicotinamide Mononucleotide and Nicotinic Acid Mononucleotide 5′-Nucleotidases Responsible for Production of Nicotinamide Riboside and Nicotinic Acid Riboside

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Systemic regulation of mammalian ageing and longevity by brain sirtuins

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The Caenorhabditis elegans nicotinamidase PNC-1 enhances survival

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Deficiency of P rdm13, a dorsomedial hypothalamus‐enriched gene, mimics age‐associated changes in sleep quality and adiposity

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Effects of intermittent fasting on health, aging, and disease

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NAD+ homeostasis in health and disease

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ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways

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(2021) · doi:10.1016/j.redox.2021.101950

Taurine deficiency as a driver of aging

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