Cited by 230Biochemical and Molecular ResearchSirtuins and Resveratrol in MedicineBacterial Genetics and Biotechnology

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Microbial NAD Metabolism: Lessons from Comparative Genomics

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Gazzaniga, Francesca, Stebbins, Rebecca, Chang, Sheila Z., McPeek, Mark A., Brenner, Charles·2009·Microbiology and Molecular Biology Reviews

DOI 10.1128/mmbr.00042-08PMC PMC2738131

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Abstract

SUMMARY: NAD is a coenzyme for redox reactions and a substrate of NAD-consuming enzymes, including ADP-ribose transferases, Sir2-related protein lysine deacetylases, and bacterial DNA ligases. Microorganisms that synthesize NAD from as few as one to as many as five of the six identified biosynthetic precursors have been identified. De novo NAD synthesis from aspartate or tryptophan is neither universal nor strictly aerobic. Salvage NAD synthesis from nicotinamide, nicotinic acid, nicotinamide riboside, and nicotinic acid riboside occurs via modules of different genes. Nicotinamide salvage genes nadV and pncA , found in distinct bacteria, appear to have spread throughout the tree of life via horizontal gene transfer. Biochemical, genetic, and genomic analyses have advanced to the point at which the precursors and pathways utilized by a microorganism can be predicted. Challenges remain in dissecting regulation of pathways.

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Authors: Gazzaniga, F., Stebbins, R., Chang, S. Z., McPeek, M. A., & Brenner, C.
Affiliations: Dartmouth College (US)
University of Iowa (US)
ORCID: Gazzaniga, Francesca
Stebbins, Rebecca
McPeek, Mark A.
Brenner, Charles
Venue: Microbiology and Molecular Biology Reviews
Publisher: American Society for Microbiology
Published: 2009-09
Volume: 73
Issue: 3
Pages: 529-541
ISSN: 1092-2172 (ISSN-L)
1098-5557
DOI: 10.1128/mmbr.00042-08
PMC: PMC2738131
OpenAlex: W2055192452
Cited by: 230
References: 76
Citations by year: 2026: 17 · 2025: 17 · 2024: 19 · 2023: 18 · 2022: 25 · 2021: 14 · 2020: 21 · 2019: 15 · 2018: 16 · 2017: 7 · 2016: 15 · 2015: 5 · 2014: 13 · 2013: 5 · 2012: 6
FWCI: 0.59
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Microbiology and Molecular Biology Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
Dartmouth College
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: NAD+ metabolism, NAD biosynthesis, nicotinamide riboside, horizontal gene transfer, pncA, comparative genomics
MeSH terms: Bacteria, NAD, Genome, Bacterial, Sequence Homology, Amino Acid, Evolution, Molecular, Gene Transfer, Horizontal, Genomics, Biosynthetic Pathways

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Microbial NAD Metabolism: Lessons from Comparative Genomics

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