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Cited by 53RNA and protein synthesis mechanismsOrigins and Evolution of LifeRNA modifications and cancer

The Peptidyl Transferase Center: a Window to the Past

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Tirumalai, Madhan R., Rivas, Mario, Tran, Quyen, Fox, George E.·2021·Microbiology and Molecular Biology Reviews
DOI 10.1128/mmbr.00104-21PMC PMC8579967
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Abstract

In his 2001 article, “Translation: in retrospect and prospect,” the late Carl Woese made a prescient observation that there was a need for the then-current view of translation to be “reformulated to become an all-embracing perspective about which 21st century Biology can develop” (RNA 7:1055–1067, 2001, https://doi.org/10.1017/s1355838201010615 ). The quest to decipher the origins of life and the road to the genetic code are both inextricably linked with the history of the ribosome. After over 60 years of research, significant progress in our understanding of how ribosomes work has been made.

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  • Ribosomal RNA is the single most abundant RNA in the cell, and both K+ and Mg2+ are essential for ribosome function.

    “Ribosomal RNA is the single most abundant RNA in the cell, and both K+ and Mg2+ are essential for ribosome function.53”

    From Metals in Motion: Understanding Labile Metal Pools in Bacteria (2025) · cites this paper as [53]

    The section “Metal Ions at the PTC in Extant Ribosomes” reports that mammalian ribosomes lose polymerizing activity without potassium and describes magnesium as indispensable for ribosome maintenance, structural integrity, and the PTC reaction. Our copy does not support the separate claim that rRNA is the single most abundant RNA in the cell (searched for cellular rRNA abundance and related terms). (LLM, conf=0.87)

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200 of 266 shown

Cited by

Sorted by citations

Authors
Tirumalai, M. R., Rivas, M., Tran, Q., & Fox, G. E.
Affiliations
University of Houston (US)
Corresponding author
Fox, George E.
ORCID
Venue
Microbiology and Molecular Biology Reviews
Publisher
American Society for Microbiology
Published
2021-12-15
Volume
85
Issue
4
Pages
e0010421-e0010421
ISSN
  • 1092-2172 (ISSN-L)
  • 1098-5557
DOI
10.1128/mmbr.00104-21
PMC
PMC8579967
OpenAlex
W3212924876
Cited by
53
References
8
Citations by year
2026: 13 · 2025: 13 · 2024: 11 · 2023: 9 · 2022: 6 · 2021: 1
FWCI
0.75
Type
journal article
Language
en
Open access
Licence
Locations
  • Microbiology and Molecular Biology Reviews (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • NASA Astrobiology Institute (NASA Postdoctoral Program)
  • NASA contract under the Center for the Origin of Life, Georgia Institute of Technology (NASA Contract 80NSSC18K1139)
  • NASA contract under the Center for the Origin of Life, Georgia Instiute of Technology (NASA Contract 80NSSC18K1139)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
Keywords
peptidyl transferase center, ribosome evolution, origin of life, origin of the genetic code, large subunit rRNA, RNA world, peptide bond formation, tRNA translocation
MeSH terms
Escherichia coli, Peptidyl Transferases, Ribosomes, RNA, Transfer, Protein Biosynthesis

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