The DOI matches its OpenAlex record; 167 of the 167 references it cites were found in a registry or an index.
Computer-aided analyses of transport protein sequences: gleaning evidence concerning function, structure, biogenesis, and evolution
Open accessAbstract
Three-dimensional structures have been elucidated for very few integral membrane proteins. Computer methods can be used as guides for estimation of solute transport protein structure, function, biogenesis, and evolution. In this paper the application of currently available computer programs to over a dozen distinct families of transport proteins is reviewed. The reliability of sequence-based topological and localization analyses and the importance of sequence and residue conservation to structure and function are evaluated. Evidence concerning the nature and frequency of occurrence of domain shuffling, splicing, fusion, deletion, and duplication during evolution of specific transport protein families is also evaluated. Channel proteins are proposed to be functionally related to carriers. It is argued that energy coupling to transport was a late occurrence, superimposed on preexisting mechanisms of solute facilitation. It is shown that several transport protein families have evolved independently of each other, employing different routes, at different times in evolutionary history, to give topologically similar transmembrane protein complexes. The possible significance of this apparent topological convergence is discussed.
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Cites
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PHYLOGENIES FROM MOLECULAR SEQUENCES: INFERENCE AND RELIABILITY
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Cited by
Pao, S. S., Paulsen, I. T., & Saier, M. H. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.1.1-34.1998 · Cited by 2,297
Self-citationDouglas, C. M., Foor, F., Marrinan, J. A., Morin, N., Nielsen, J. B., Dahl, A. M., Mazur, P., Baginsky, W., Li, W., & el-Sherbeini, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12907 · Cited by 401
PRICE, T. N., JACKSON, N. V., & HALESTRAP, P. A. (1998) · Biochemical Journal · doi:10.1042/bj3290321 · Cited by 361
Yeast ATP-Binding Cassette Transporters Conferring Multidrug Resistance
Prasad, R., & Goffeau, A. (2012) · Annual Review of Microbiology · doi:10.1146/annurev-micro-092611-150111 · Cited by 221
Smith, R. L., Thompson, L. J., & Maguire, M. E. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.5.1233-1238.1995 · Cited by 127
Metadata
- Authors
- Saier, M. H.
- Venue
- Microbiological Reviews
- Publisher
- American Society for Microbiology
- Published
- 1994-01-01
- Volume
- 58
- Issue
- 1
- Pages
- 71-93
- ISSN
- 0146-0749 (ISSN-L)
- OpenAlex
- W1868327346
- Cited by
- 275
- References
- 167
- FWCI
- 8.95
- Type
- journal article
- Language
- en
- Open access
- diamond
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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